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ACTH stimulation test in lean polycystic ovary syndrome patients with insulin resistance.
Fertil Steril. 2007 Sep; 88(3):670-4.FS

Abstract

OBJECTIVE

To determine whether insulin resistance in nonobese polycystic ovarian syndrome (PCOS) patients is associated with a higher response to ACTH stimulation.

DESIGN

Controlled prospective study.

SETTING

University hospital ambulatory care unit.

PATIENT(S)

Twenty nonobese PCOS syndrome patients with insulin resistance and a body mass index-matched control group of 20 nonobese PCOS patients without insulin resistance.

INTERVENTION(S)

A 75-g oral glucose tolerance test and an ACTH stimulation test.

MAIN OUTCOME MEASURE(S)

Blood insulin and glucose levels after ingestion of 75 g oral glucose; blood androstenedione (A), 17(OH)-progesterone [17(OH)-P], free and total T, DHEAS, and progesterone (P) response to ACTH stimulation.

RESULT(S)

The proportional increases in the blood levels of total and free T, DHEAS, A, 17(OH)-P, and P following ACTH stimulation were similar in the two groups. Only the insulin area under the curve (AUC) values were significantly different among the two groups. The insulin AUC values were positively correlated to the free T blood levels and the homeostasis model assessment scores.

CONCLUSION(S)

Within the population of nonobese PCOS patients, insulin resistance is not associated with a more pronounced response to ACTH stimulation. The pathogenesis and management of PCOS in nonobese patients may be different from in obese patients.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, Medical Faculty, Uludag University, Gorukle-Bursa, Turkey. eozyurek@yahoo.com <eozyurek@yahoo.com>No affiliation info availableNo affiliation info available

Pub Type(s)

Controlled Clinical Trial
Journal Article

Language

eng

PubMed ID

17451692

Citation

Uncu, Gurkan, et al. "ACTH Stimulation Test in Lean Polycystic Ovary Syndrome Patients With Insulin Resistance." Fertility and Sterility, vol. 88, no. 3, 2007, pp. 670-4.
Uncu G, Ozyurek SE, Uncu Y. ACTH stimulation test in lean polycystic ovary syndrome patients with insulin resistance. Fertil Steril. 2007;88(3):670-4.
Uncu, G., Ozyurek, S. E., & Uncu, Y. (2007). ACTH stimulation test in lean polycystic ovary syndrome patients with insulin resistance. Fertility and Sterility, 88(3), 670-4.
Uncu G, Ozyurek SE, Uncu Y. ACTH Stimulation Test in Lean Polycystic Ovary Syndrome Patients With Insulin Resistance. Fertil Steril. 2007;88(3):670-4. PubMed PMID: 17451692.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - ACTH stimulation test in lean polycystic ovary syndrome patients with insulin resistance. AU - Uncu,Gurkan, AU - Ozyurek,S Eser, AU - Uncu,Yesim, Y1 - 2007/04/23/ PY - 2006/04/23/received PY - 2006/12/09/revised PY - 2006/12/09/accepted PY - 2007/4/25/pubmed PY - 2007/9/26/medline PY - 2007/4/25/entrez SP - 670 EP - 4 JF - Fertility and sterility JO - Fertil. Steril. VL - 88 IS - 3 N2 - OBJECTIVE: To determine whether insulin resistance in nonobese polycystic ovarian syndrome (PCOS) patients is associated with a higher response to ACTH stimulation. DESIGN: Controlled prospective study. SETTING: University hospital ambulatory care unit. PATIENT(S): Twenty nonobese PCOS syndrome patients with insulin resistance and a body mass index-matched control group of 20 nonobese PCOS patients without insulin resistance. INTERVENTION(S): A 75-g oral glucose tolerance test and an ACTH stimulation test. MAIN OUTCOME MEASURE(S): Blood insulin and glucose levels after ingestion of 75 g oral glucose; blood androstenedione (A), 17(OH)-progesterone [17(OH)-P], free and total T, DHEAS, and progesterone (P) response to ACTH stimulation. RESULT(S): The proportional increases in the blood levels of total and free T, DHEAS, A, 17(OH)-P, and P following ACTH stimulation were similar in the two groups. Only the insulin area under the curve (AUC) values were significantly different among the two groups. The insulin AUC values were positively correlated to the free T blood levels and the homeostasis model assessment scores. CONCLUSION(S): Within the population of nonobese PCOS patients, insulin resistance is not associated with a more pronounced response to ACTH stimulation. The pathogenesis and management of PCOS in nonobese patients may be different from in obese patients. SN - 1556-5653 UR - https://www.unboundmedicine.com/medline/citation/17451692/ACTH_stimulation_test_in_lean_polycystic_ovary_syndrome_patients_with_insulin_resistance_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0015-0282(07)00036-2 DB - PRIME DP - Unbound Medicine ER -