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A structural equation modeling investigation of age-related variance in executive function and DTI measured white matter damage.
Neurobiol Aging 2008; 29(10):1547-55NA

Abstract

Cognitive changes in normal aging have been explained by the frontal-executive hypothesis, but the assumptions made by this hypothesis concerning the neurobiological causes are still a matter of debate. Executive functions (EF) may activate neural networks that include disparate grey matter regions, and rely on the integrity of white matter connections. In 118 adults (50-90 years old) from the GENIE study, white matter integrity was measured using diffusion tensor imaging, and information processing speed, fluid intelligence and EF were assessed. A theory-driven structural equation model was developed to test associations between variables. The model was revised, removing non-significant paths. The adjusted model explained well the covariance in our data; and suggested that the reduction in white matter integrity associated with age directly affected only working memory. Fluid intelligence was mediated by all measured cognitive variables. The results suggest that white matter integrity may be particularly important for abilities activating complex neural networks, as occurs in working memory. Integration of the information processing speed and frontal-executive hypotheses may provide important information regarding common, unique, and mediating factors in cognitive aging.

Authors+Show Affiliations

Clinical Neuroscience, St. George's University of London, Cranmer Terrace, London SW17 0RE, UK. rcharlton@sgul.ac.ukNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17451845

Citation

Charlton, R A., et al. "A Structural Equation Modeling Investigation of Age-related Variance in Executive Function and DTI Measured White Matter Damage." Neurobiology of Aging, vol. 29, no. 10, 2008, pp. 1547-55.
Charlton RA, Landau S, Schiavone F, et al. A structural equation modeling investigation of age-related variance in executive function and DTI measured white matter damage. Neurobiol Aging. 2008;29(10):1547-55.
Charlton, R. A., Landau, S., Schiavone, F., Barrick, T. R., Clark, C. A., Markus, H. S., & Morris, R. G. (2008). A structural equation modeling investigation of age-related variance in executive function and DTI measured white matter damage. Neurobiology of Aging, 29(10), pp. 1547-55.
Charlton RA, et al. A Structural Equation Modeling Investigation of Age-related Variance in Executive Function and DTI Measured White Matter Damage. Neurobiol Aging. 2008;29(10):1547-55. PubMed PMID: 17451845.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A structural equation modeling investigation of age-related variance in executive function and DTI measured white matter damage. AU - Charlton,R A, AU - Landau,S, AU - Schiavone,F, AU - Barrick,T R, AU - Clark,C A, AU - Markus,H S, AU - Morris,R G, Y1 - 2007/04/23/ PY - 2006/03/31/received PY - 2007/03/13/revised PY - 2007/03/17/accepted PY - 2007/4/25/pubmed PY - 2008/11/18/medline PY - 2007/4/25/entrez SP - 1547 EP - 55 JF - Neurobiology of aging JO - Neurobiol. Aging VL - 29 IS - 10 N2 - Cognitive changes in normal aging have been explained by the frontal-executive hypothesis, but the assumptions made by this hypothesis concerning the neurobiological causes are still a matter of debate. Executive functions (EF) may activate neural networks that include disparate grey matter regions, and rely on the integrity of white matter connections. In 118 adults (50-90 years old) from the GENIE study, white matter integrity was measured using diffusion tensor imaging, and information processing speed, fluid intelligence and EF were assessed. A theory-driven structural equation model was developed to test associations between variables. The model was revised, removing non-significant paths. The adjusted model explained well the covariance in our data; and suggested that the reduction in white matter integrity associated with age directly affected only working memory. Fluid intelligence was mediated by all measured cognitive variables. The results suggest that white matter integrity may be particularly important for abilities activating complex neural networks, as occurs in working memory. Integration of the information processing speed and frontal-executive hypotheses may provide important information regarding common, unique, and mediating factors in cognitive aging. SN - 1558-1497 UR - https://www.unboundmedicine.com/medline/citation/17451845/A_structural_equation_modeling_investigation_of_age_related_variance_in_executive_function_and_DTI_measured_white_matter_damage_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0197-4580(07)00126-1 DB - PRIME DP - Unbound Medicine ER -