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Circulating concentrations of adiponectin and tumor necrosis factor-alpha in gestational diabetes mellitus.
Gynecol Endocrinol. 2007 Mar; 23(3):161-5.GE

Abstract

Adiponectin and tumor necrosis factor-alpha (TNF-alpha) have been implicated in insulin resistance and diabetes mellitus (DM). In the present study we investigated levels of adiponectin and TNF-alpha and their relationships with each other and metabolic factors in women with gestational DM (GDM). Thirty-four pregnant women with GDM and 31 pregnant women with normal glucose tolerance (NGT) were included in the study. Plasma adiponectin levels were lower in GDM than in NGT (36.9 +/- 6.7 vs. 61.3 +/- 13.0 ng/ml, p = 0.028). Serum TNF-alpha levels were increased in GDM compared with NGT (20.5 +/- 2.4 vs. 14.0 +/- 1.5 pg/ml, p = 0.042). After adjustment for pre-pregnancy and current body mass index (BMI), adiponectin levels correlated negatively with insulin resistance by homeostasis model assessment-insulin resistance (HOMA-IR) and 0-h and 1-h glucose both at glucose challenge test and oral glucose tolerance test in GDM. Adiponectin levels were correlated only with very low-density lipoprotein cholesterol and triglyceride levels in NGT. TNF-alpha levels were correlated with glycated hemoglobin in GDM. There was a significant positive correlation between TNF-alpha levels and pre-pregnancy and current BMI in GDM as well as NGT. HOMA-IR for adiponectin and pre-pregnancy BMI for TNF-alpha remained as significant determinants in multiple regression analyses. In conclusion, these data suggest that reduced adiponectin and increased TNF-alpha may be involved in the pathogenesis of GDM.

Authors+Show Affiliations

Department of Endocrinology and Metabolism, Gazi University Faculty of Medicine, Ankara, Turkey. alevaltinova@yahoo.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17454170

Citation

Altinova, Alev E., et al. "Circulating Concentrations of Adiponectin and Tumor Necrosis Factor-alpha in Gestational Diabetes Mellitus." Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology, vol. 23, no. 3, 2007, pp. 161-5.
Altinova AE, Toruner F, Bozkurt N, et al. Circulating concentrations of adiponectin and tumor necrosis factor-alpha in gestational diabetes mellitus. Gynecol Endocrinol. 2007;23(3):161-5.
Altinova, A. E., Toruner, F., Bozkurt, N., Bukan, N., Karakoc, A., Yetkin, I., Ayvaz, G., Cakir, N., & Arslan, M. (2007). Circulating concentrations of adiponectin and tumor necrosis factor-alpha in gestational diabetes mellitus. Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology, 23(3), 161-5.
Altinova AE, et al. Circulating Concentrations of Adiponectin and Tumor Necrosis Factor-alpha in Gestational Diabetes Mellitus. Gynecol Endocrinol. 2007;23(3):161-5. PubMed PMID: 17454170.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Circulating concentrations of adiponectin and tumor necrosis factor-alpha in gestational diabetes mellitus. AU - Altinova,Alev E, AU - Toruner,Fusun, AU - Bozkurt,Nuray, AU - Bukan,Neslihan, AU - Karakoc,Ayhan, AU - Yetkin,Ilhan, AU - Ayvaz,Goksun, AU - Cakir,Nuri, AU - Arslan,Metin, PY - 2007/4/25/pubmed PY - 2007/6/27/medline PY - 2007/4/25/entrez SP - 161 EP - 5 JF - Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology JO - Gynecol. Endocrinol. VL - 23 IS - 3 N2 - Adiponectin and tumor necrosis factor-alpha (TNF-alpha) have been implicated in insulin resistance and diabetes mellitus (DM). In the present study we investigated levels of adiponectin and TNF-alpha and their relationships with each other and metabolic factors in women with gestational DM (GDM). Thirty-four pregnant women with GDM and 31 pregnant women with normal glucose tolerance (NGT) were included in the study. Plasma adiponectin levels were lower in GDM than in NGT (36.9 +/- 6.7 vs. 61.3 +/- 13.0 ng/ml, p = 0.028). Serum TNF-alpha levels were increased in GDM compared with NGT (20.5 +/- 2.4 vs. 14.0 +/- 1.5 pg/ml, p = 0.042). After adjustment for pre-pregnancy and current body mass index (BMI), adiponectin levels correlated negatively with insulin resistance by homeostasis model assessment-insulin resistance (HOMA-IR) and 0-h and 1-h glucose both at glucose challenge test and oral glucose tolerance test in GDM. Adiponectin levels were correlated only with very low-density lipoprotein cholesterol and triglyceride levels in NGT. TNF-alpha levels were correlated with glycated hemoglobin in GDM. There was a significant positive correlation between TNF-alpha levels and pre-pregnancy and current BMI in GDM as well as NGT. HOMA-IR for adiponectin and pre-pregnancy BMI for TNF-alpha remained as significant determinants in multiple regression analyses. In conclusion, these data suggest that reduced adiponectin and increased TNF-alpha may be involved in the pathogenesis of GDM. SN - 0951-3590 UR - https://www.unboundmedicine.com/medline/citation/17454170/Circulating_concentrations_of_adiponectin_and_tumor_necrosis_factor_alpha_in_gestational_diabetes_mellitus_ L2 - http://www.tandfonline.com/doi/full/10.1080/09513590701227960 DB - PRIME DP - Unbound Medicine ER -