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Serum ionized magnesium and calcium levels in adult patients with seizures.

Abstract

OBJECTIVE

Prior studies have been equivocal about whether or not serum levels of the divalent ions calcium and magnesium are altered during different types of seizures. Magnesium is a potential modulator of seizure activity because of its ability to antagonize the excitatory calcium influx through the N-methyl-D-aspartate (NMDA) receptor. We hypothesize that serum ionized levels of calcium (Ca(2+)) and magnesium (Mg(2+)) would be altered significantly during certain types of seizures.

MATERIAL AND METHODS

A convenience sample of seizure patients presenting to an emergency department (ED) were enrolled in this prospective study. Novel ion-selective electrodes were used to measure Ca(2+) and Mg(2+). Data were reported as mean values+/-standard deviations. Group comparisons were analyzed by ANOVA with post-hoc testing using the Bonferroni, or the Fisher exact test, where appropriate, alpha = 0.05 (two-tailed).

RESULTS

Forty-nine patients with seizure and 32 healthy racially matched controls were included in the study. Seizure patients had a significantly (p<0.001) lower mean Mg(2+), but not total serum Mg and a significantly (p<0.001) higher Ca(2+)/Mg(2+) ratio than that in controls.

CONCLUSIONS

We were able to show significantly lower Mg(2+) and higher ionized Ca(2+)/Mg(2+) ratios in seizure patients compared with a racially matched control group.

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  • Authors+Show Affiliations

    ,

    Department of Emergency Medicine, State University of New Yourk, Downstate Medical Center, Brooklyn, NY 11203, USA. neprhon1@bellatlantic.net

    , , , ,

    Source

    MeSH

    Adult
    Anticonvulsants
    Calcium
    Female
    Humans
    Ion-Selective Electrodes
    Ions
    Magnesium
    Male
    Middle Aged
    Prospective Studies
    Reference Values
    Seizures

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    17454846

    Citation

    Sinert, R, et al. "Serum Ionized Magnesium and Calcium Levels in Adult Patients With Seizures." Scandinavian Journal of Clinical and Laboratory Investigation, vol. 67, no. 3, 2007, pp. 317-26.
    Sinert R, Zehtabchi S, Desai S, et al. Serum ionized magnesium and calcium levels in adult patients with seizures. Scand J Clin Lab Invest. 2007;67(3):317-26.
    Sinert, R., Zehtabchi, S., Desai, S., Peacock, P., Altura, B. T., & Altura, B. M. (2007). Serum ionized magnesium and calcium levels in adult patients with seizures. Scandinavian Journal of Clinical and Laboratory Investigation, 67(3), pp. 317-26.
    Sinert R, et al. Serum Ionized Magnesium and Calcium Levels in Adult Patients With Seizures. Scand J Clin Lab Invest. 2007;67(3):317-26. PubMed PMID: 17454846.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Serum ionized magnesium and calcium levels in adult patients with seizures. AU - Sinert,R, AU - Zehtabchi,S, AU - Desai,S, AU - Peacock,P, AU - Altura,B T, AU - Altura,B M, PY - 2007/4/25/pubmed PY - 2007/8/31/medline PY - 2007/4/25/entrez SP - 317 EP - 26 JF - Scandinavian journal of clinical and laboratory investigation JO - Scand. J. Clin. Lab. Invest. VL - 67 IS - 3 N2 - OBJECTIVE: Prior studies have been equivocal about whether or not serum levels of the divalent ions calcium and magnesium are altered during different types of seizures. Magnesium is a potential modulator of seizure activity because of its ability to antagonize the excitatory calcium influx through the N-methyl-D-aspartate (NMDA) receptor. We hypothesize that serum ionized levels of calcium (Ca(2+)) and magnesium (Mg(2+)) would be altered significantly during certain types of seizures. MATERIAL AND METHODS: A convenience sample of seizure patients presenting to an emergency department (ED) were enrolled in this prospective study. Novel ion-selective electrodes were used to measure Ca(2+) and Mg(2+). Data were reported as mean values+/-standard deviations. Group comparisons were analyzed by ANOVA with post-hoc testing using the Bonferroni, or the Fisher exact test, where appropriate, alpha = 0.05 (two-tailed). RESULTS: Forty-nine patients with seizure and 32 healthy racially matched controls were included in the study. Seizure patients had a significantly (p<0.001) lower mean Mg(2+), but not total serum Mg and a significantly (p<0.001) higher Ca(2+)/Mg(2+) ratio than that in controls. CONCLUSIONS: We were able to show significantly lower Mg(2+) and higher ionized Ca(2+)/Mg(2+) ratios in seizure patients compared with a racially matched control group. SN - 0036-5513 UR - https://www.unboundmedicine.com/medline/citation/17454846/Serum_ionized_magnesium_and_calcium_levels_in_adult_patients_with_seizures_ L2 - http://www.tandfonline.com/doi/full/10.1080/00365510601051441 DB - PRIME DP - Unbound Medicine ER -