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The 3-D model: experimental testing of the parameters d, e, and omega and validation of the analysis.
J Pharm Sci. 2007 May; 96(5):1408-17.JP

Abstract

The aim of the study was to evaluate the parameters d, e, and omega for their significance in compression data analysis. Materials with predominantly different compression properties were used and tableting data were obtained with an instrumented eccentric and rotary tableting machine. The parameters time plasticity (d), pressure plasticity (e), and the twisting angle (omega), an indicator of fast elastic decompression, were derived by 3-D modeling. The Peak-Offset-Time, the pressure-time function parameters, the Heckel slope, normalized compaction (E2(norm)) and elastic energy (E3(norm)), and fast elastic recovery (FER), which are well known tableting parameters, were calculated from the tableting data. The plastic microhardness of the tablets was determined from using microindentation. The results revealed that d is influenced by speed, e correlates with microhardness, and omega correlates with the Elastic modulus (E). Thus, for all three 3-D model parameters an experimental basis is given. The validation showed that d correlates with the Peak-Offset-Time and the pressure-time function parameters, e correlates with the Heckel slope and E2(norm), and omega correlates with E3(norm) and FER of the tablets. The significance of the three parameters is fully given. It is no longer necessary to use two separate methods to differentiate between time- and pressure-dependent deformations.

Authors+Show Affiliations

Martin-Luther-University Halle-Wittenberg, Institute of Pharmaceutics and Biopharmaceutics, Wolfgang-Langenbeck-Str. 4, 06120 Halle/Saale, Germany. katharina.picker-freyer@pharmazie.uni-halle.de

Pub Type(s)

Comparative Study
Journal Article
Validation Study

Language

eng

PubMed ID

17455352

Citation

Picker-Freyer, Katharina Maria. "The 3-D Model: Experimental Testing of the Parameters D, E, and Omega and Validation of the Analysis." Journal of Pharmaceutical Sciences, vol. 96, no. 5, 2007, pp. 1408-17.
Picker-Freyer KM. The 3-D model: experimental testing of the parameters d, e, and omega and validation of the analysis. J Pharm Sci. 2007;96(5):1408-17.
Picker-Freyer, K. M. (2007). The 3-D model: experimental testing of the parameters d, e, and omega and validation of the analysis. Journal of Pharmaceutical Sciences, 96(5), 1408-17.
Picker-Freyer KM. The 3-D Model: Experimental Testing of the Parameters D, E, and Omega and Validation of the Analysis. J Pharm Sci. 2007;96(5):1408-17. PubMed PMID: 17455352.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The 3-D model: experimental testing of the parameters d, e, and omega and validation of the analysis. A1 - Picker-Freyer,Katharina Maria, PY - 2007/4/25/pubmed PY - 2007/6/15/medline PY - 2007/4/25/entrez SP - 1408 EP - 17 JF - Journal of pharmaceutical sciences JO - J Pharm Sci VL - 96 IS - 5 N2 - The aim of the study was to evaluate the parameters d, e, and omega for their significance in compression data analysis. Materials with predominantly different compression properties were used and tableting data were obtained with an instrumented eccentric and rotary tableting machine. The parameters time plasticity (d), pressure plasticity (e), and the twisting angle (omega), an indicator of fast elastic decompression, were derived by 3-D modeling. The Peak-Offset-Time, the pressure-time function parameters, the Heckel slope, normalized compaction (E2(norm)) and elastic energy (E3(norm)), and fast elastic recovery (FER), which are well known tableting parameters, were calculated from the tableting data. The plastic microhardness of the tablets was determined from using microindentation. The results revealed that d is influenced by speed, e correlates with microhardness, and omega correlates with the Elastic modulus (E). Thus, for all three 3-D model parameters an experimental basis is given. The validation showed that d correlates with the Peak-Offset-Time and the pressure-time function parameters, e correlates with the Heckel slope and E2(norm), and omega correlates with E3(norm) and FER of the tablets. The significance of the three parameters is fully given. It is no longer necessary to use two separate methods to differentiate between time- and pressure-dependent deformations. SN - 0022-3549 UR - https://www.unboundmedicine.com/medline/citation/17455352/The_3_D_model:_experimental_testing_of_the_parameters_d_e_and_omega_and_validation_of_the_analysis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0022-3549(16)32250-X DB - PRIME DP - Unbound Medicine ER -