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Aurantiomides A-C, quinazoline alkaloids from the sponge-derived fungus Penicillium aurantiogriseum SP0-19.
J Nat Prod. 2007 May; 70(5):853-5.JN

Abstract

Three new quinazoline alkaloids, aurantiomides A (1), B (2), and C (3), along with the known metabolite anacine (4) were isolated from the sponge-derived fungus strain Penicillium aurantiogriseum SP0-19 by bioassay-guided fractionation. Their structures were elucidated by spectroscopic and chemical methods. Their absolute configurations were deduced by comparison of their Cotton effects with anacine (4) and by chemical transformations. Compounds 2 and 3 showed moderate cytotoxicities against HL-60, P388 and BEL-7402, P388 cell lines, respectively.

Authors+Show Affiliations

Xin ZH
Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, People's Republic of China.
Fang Y
No affiliation info available
Du L
No affiliation info available
Zhu T
No affiliation info available
Duan L
No affiliation info available
Chen J
No affiliation info available
Gu QQ
No affiliation info available
Zhu WM
No affiliation info available

MeSH

AlkaloidsAnimalsDrug Screening Assays, AntitumorHumansLeukemia P388MiceMolecular StructurePenicilliumPoriferaQuinazolines

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17455978

Citation

Xin, Zhi Hong, et al. "Aurantiomides A-C, Quinazoline Alkaloids From the Sponge-derived Fungus Penicillium Aurantiogriseum SP0-19." Journal of Natural Products, vol. 70, no. 5, 2007, pp. 853-5.
Xin ZH, Fang Y, Du L, et al. Aurantiomides A-C, quinazoline alkaloids from the sponge-derived fungus Penicillium aurantiogriseum SP0-19. J Nat Prod. 2007;70(5):853-5.
Xin, Z. H., Fang, Y., Du, L., Zhu, T., Duan, L., Chen, J., Gu, Q. Q., & Zhu, W. M. (2007). Aurantiomides A-C, quinazoline alkaloids from the sponge-derived fungus Penicillium aurantiogriseum SP0-19. Journal of Natural Products, 70(5), 853-5.
Xin ZH, et al. Aurantiomides A-C, Quinazoline Alkaloids From the Sponge-derived Fungus Penicillium Aurantiogriseum SP0-19. J Nat Prod. 2007;70(5):853-5. PubMed PMID: 17455978.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Aurantiomides A-C, quinazoline alkaloids from the sponge-derived fungus Penicillium aurantiogriseum SP0-19. AU - Xin,Zhi Hong, AU - Fang,Yuchun, AU - Du,Lin, AU - Zhu,Tianjiao, AU - Duan,Lin, AU - Chen,Juan, AU - Gu,Qian-Qun, AU - Zhu,Wei-Ming, Y1 - 2007/04/25/ PY - 2007/4/26/pubmed PY - 2007/7/17/medline PY - 2007/4/26/entrez SP - 853 EP - 5 JF - Journal of natural products JO - J Nat Prod VL - 70 IS - 5 N2 - Three new quinazoline alkaloids, aurantiomides A (1), B (2), and C (3), along with the known metabolite anacine (4) were isolated from the sponge-derived fungus strain Penicillium aurantiogriseum SP0-19 by bioassay-guided fractionation. Their structures were elucidated by spectroscopic and chemical methods. Their absolute configurations were deduced by comparison of their Cotton effects with anacine (4) and by chemical transformations. Compounds 2 and 3 showed moderate cytotoxicities against HL-60, P388 and BEL-7402, P388 cell lines, respectively. SN - 0163-3864 UR - https://www.unboundmedicine.com/medline/citation/17455978/Aurantiomides_A_C_quinazoline_alkaloids_from_the_sponge_derived_fungus_Penicillium_aurantiogriseum_SP0_19_ L2 - https://doi.org/10.1021/np060516h DB - PRIME DP - Unbound Medicine ER -