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[Changes of intercellular spaces of esophageal epithelium in patients with gastroesophageal reflux disease before and after esomeprazole treatment].
Zhonghua Yi Xue Za Zhi. 2007 Feb 06; 87(6):392-5.ZY

Abstract

OBJECTIVE

To observe the changes of dilated intercellular space (DIS) of esophageal epithelium in different subtypes of gastroesophageal reflux disease (GERD) before and after esomeprazole treatment.

METHODS

Nineteen patients with GERD, 6 with erosive esophagitis (EE), 7 with NERD with abnormal acid exposure (NERD pH+), and 6 with NERD with normal acid exposure (NERD pH-), were treated with esomeprazole 40 mg daily for two months. During endoscopy before and after treatment, six biopsy specimens were taken from the apparently normal mucosa 3 - 5 cm above the dentate line in the esophagus to undergo HE staining and histological examination and transmission electron microscopy (TEM). Fifteen normal subjects were used as controls.

RESULTS

Two months after the treatment 5 cases (83.33%) in the EE group, 6 cases (85.57%) in the NERD pH+ group, and 5 cases (83.33%) in the NERD pH- group showed a complete recovery of DIS and complete disappearance of the symptom of heartburn. Two of the left three patients who showed incomplete recovery of DIS still had heartburn.

CONCLUSION

A complete recovery of DIS 2 months after treatment of esomeprazole is always accompanied by resolution of heartburn symptom. No significant difference in complete recovery of DIS can be found among different GERD subgroups.

Authors+Show Affiliations

Department of Gastroenterology, First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Randomized Controlled Trial

Language

chi

PubMed ID

17456380

Citation

Tao, Jin, et al. "[Changes of Intercellular Spaces of Esophageal Epithelium in Patients With Gastroesophageal Reflux Disease Before and After Esomeprazole Treatment]." Zhonghua Yi Xue Za Zhi, vol. 87, no. 6, 2007, pp. 392-5.
Tao J, Xiao YL, Chen MH, et al. [Changes of intercellular spaces of esophageal epithelium in patients with gastroesophageal reflux disease before and after esomeprazole treatment]. Zhonghua Yi Xue Za Zhi. 2007;87(6):392-5.
Tao, J., Xiao, Y. L., Chen, M. H., Peng, S., Lin, J. K., Xiong, L. S., & Hu, P. J. (2007). [Changes of intercellular spaces of esophageal epithelium in patients with gastroesophageal reflux disease before and after esomeprazole treatment]. Zhonghua Yi Xue Za Zhi, 87(6), 392-5.
Tao J, et al. [Changes of Intercellular Spaces of Esophageal Epithelium in Patients With Gastroesophageal Reflux Disease Before and After Esomeprazole Treatment]. Zhonghua Yi Xue Za Zhi. 2007 Feb 6;87(6):392-5. PubMed PMID: 17456380.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Changes of intercellular spaces of esophageal epithelium in patients with gastroesophageal reflux disease before and after esomeprazole treatment]. AU - Tao,Jin, AU - Xiao,Ying-Lian, AU - Chen,Min-Hu, AU - Peng,Sui, AU - Lin,Jin-Kun, AU - Xiong,Li-Shou, AU - Hu,Pin-Jin, PY - 2007/4/26/pubmed PY - 2008/10/22/medline PY - 2007/4/26/entrez SP - 392 EP - 5 JF - Zhonghua yi xue za zhi JO - Zhonghua Yi Xue Za Zhi VL - 87 IS - 6 N2 - OBJECTIVE: To observe the changes of dilated intercellular space (DIS) of esophageal epithelium in different subtypes of gastroesophageal reflux disease (GERD) before and after esomeprazole treatment. METHODS: Nineteen patients with GERD, 6 with erosive esophagitis (EE), 7 with NERD with abnormal acid exposure (NERD pH+), and 6 with NERD with normal acid exposure (NERD pH-), were treated with esomeprazole 40 mg daily for two months. During endoscopy before and after treatment, six biopsy specimens were taken from the apparently normal mucosa 3 - 5 cm above the dentate line in the esophagus to undergo HE staining and histological examination and transmission electron microscopy (TEM). Fifteen normal subjects were used as controls. RESULTS: Two months after the treatment 5 cases (83.33%) in the EE group, 6 cases (85.57%) in the NERD pH+ group, and 5 cases (83.33%) in the NERD pH- group showed a complete recovery of DIS and complete disappearance of the symptom of heartburn. Two of the left three patients who showed incomplete recovery of DIS still had heartburn. CONCLUSION: A complete recovery of DIS 2 months after treatment of esomeprazole is always accompanied by resolution of heartburn symptom. No significant difference in complete recovery of DIS can be found among different GERD subgroups. SN - 0376-2491 UR - https://www.unboundmedicine.com/medline/citation/17456380/[Changes_of_intercellular_spaces_of_esophageal_epithelium_in_patients_with_gastroesophageal_reflux_disease_before_and_after_esomeprazole_treatment]_ L2 - http://journal.yiigle.com/LinkIn.do?linkin_type=pubmed&issn=0376-2491&year=2007&vol=87&issue=6&fpage=392 DB - PRIME DP - Unbound Medicine ER -