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Long-term effects of a plant-based dietary portfolio of cholesterol-lowering foods on blood pressure.
Eur J Clin Nutr 2008; 62(6):781-8EJ

Abstract

OBJECTIVE

To determine the effect on blood pressure of dietary advice to consume a combination of plant-based cholesterol-lowering foods (dietary portfolio).

METHODS

For 1 year, 66 hyperlipidemic subjects were prescribed diets high in plant sterols (1.0 g/1000 kcal), soy protein (22.5 g/1000 kcal), viscous fibers (10 g/1000 kcal) and almonds (22.5 g/1000 kcal). There was no control group. Seven-day diet record, blood pressure and body weight were monitored initially monthly and later at 2-monthly intervals throughout the study.

RESULTS

Fifty subjects completed the 1-year study. When the last observation was carried forward for non-completers (n=9) or those who changed their blood pressure medications (n=7), a small mean reduction was seen in body weight 0.7+/-0.3 kg (P=0.036). The corresponding reductions from baseline in systolic and diastolic blood pressure at 1 year (n=66 subjects) were -4.2+/-1.3 mm Hg (P=0.002) and -2.3+/-0.7 mm Hg (P=0.001), respectively. Blood pressure reductions occurred within the first 2 weeks, with stable blood pressures 6 weeks before and 4 weeks after starting the diet. Diastolic blood pressure reduction was significantly related to weight change (r=0.30, n=50, P=0.036). Only compliance with almond intake advice related to blood pressure reduction (systolic: r=-0.34, n=50, P=0.017; diastolic: r=-0.29, n=50, P=0.041).

CONCLUSIONS

A dietary portfolio of plant-based cholesterol-lowering foods reduced blood pressure significantly, related to almond intake. The dietary portfolio approach of combining a range of cholesterol-lowering plant foods may benefit cardiovascular disease risk both by reducing serum lipids and also blood pressure.

Authors+Show Affiliations

Clinical Nutrition & Risk Factor Modification Center, St Michael's Hospital, Toronto, ON, Canada.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17457340

Citation

Jenkins, D J A., et al. "Long-term Effects of a Plant-based Dietary Portfolio of Cholesterol-lowering Foods On Blood Pressure." European Journal of Clinical Nutrition, vol. 62, no. 6, 2008, pp. 781-8.
Jenkins DJ, Kendall CW, Faulkner DA, et al. Long-term effects of a plant-based dietary portfolio of cholesterol-lowering foods on blood pressure. Eur J Clin Nutr. 2008;62(6):781-8.
Jenkins, D. J., Kendall, C. W., Faulkner, D. A., Kemp, T., Marchie, A., Nguyen, T. H., ... Singer, W. (2008). Long-term effects of a plant-based dietary portfolio of cholesterol-lowering foods on blood pressure. European Journal of Clinical Nutrition, 62(6), pp. 781-8.
Jenkins DJ, et al. Long-term Effects of a Plant-based Dietary Portfolio of Cholesterol-lowering Foods On Blood Pressure. Eur J Clin Nutr. 2008;62(6):781-8. PubMed PMID: 17457340.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Long-term effects of a plant-based dietary portfolio of cholesterol-lowering foods on blood pressure. AU - Jenkins,D J A, AU - Kendall,C W C, AU - Faulkner,D A, AU - Kemp,T, AU - Marchie,A, AU - Nguyen,T H, AU - Wong,J M W, AU - de Souza,R, AU - Emam,A, AU - Vidgen,E, AU - Trautwein,E A, AU - Lapsley,K G, AU - Josse,R G, AU - Leiter,L A, AU - Singer,W, Y1 - 2007/04/25/ PY - 2007/4/26/pubmed PY - 2008/10/24/medline PY - 2007/4/26/entrez SP - 781 EP - 8 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 62 IS - 6 N2 - OBJECTIVE: To determine the effect on blood pressure of dietary advice to consume a combination of plant-based cholesterol-lowering foods (dietary portfolio). METHODS: For 1 year, 66 hyperlipidemic subjects were prescribed diets high in plant sterols (1.0 g/1000 kcal), soy protein (22.5 g/1000 kcal), viscous fibers (10 g/1000 kcal) and almonds (22.5 g/1000 kcal). There was no control group. Seven-day diet record, blood pressure and body weight were monitored initially monthly and later at 2-monthly intervals throughout the study. RESULTS: Fifty subjects completed the 1-year study. When the last observation was carried forward for non-completers (n=9) or those who changed their blood pressure medications (n=7), a small mean reduction was seen in body weight 0.7+/-0.3 kg (P=0.036). The corresponding reductions from baseline in systolic and diastolic blood pressure at 1 year (n=66 subjects) were -4.2+/-1.3 mm Hg (P=0.002) and -2.3+/-0.7 mm Hg (P=0.001), respectively. Blood pressure reductions occurred within the first 2 weeks, with stable blood pressures 6 weeks before and 4 weeks after starting the diet. Diastolic blood pressure reduction was significantly related to weight change (r=0.30, n=50, P=0.036). Only compliance with almond intake advice related to blood pressure reduction (systolic: r=-0.34, n=50, P=0.017; diastolic: r=-0.29, n=50, P=0.041). CONCLUSIONS: A dietary portfolio of plant-based cholesterol-lowering foods reduced blood pressure significantly, related to almond intake. The dietary portfolio approach of combining a range of cholesterol-lowering plant foods may benefit cardiovascular disease risk both by reducing serum lipids and also blood pressure. SN - 0954-3007 UR - https://www.unboundmedicine.com/medline/citation/17457340/Long_term_effects_of_a_plant_based_dietary_portfolio_of_cholesterol_lowering_foods_on_blood_pressure_ L2 - http://dx.doi.org/10.1038/sj.ejcn.1602768 DB - PRIME DP - Unbound Medicine ER -