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In vivo quantification of microvessels in clinically uninvolved psoriatic skin and in normal skin.
Br J Dermatol. 2007 Jun; 156(6):1224-9.BJ

Abstract

BACKGROUND

Microvascular abnormalities (capillary elongation, widening and tortuosity) are a characteristic feature of psoriasis and form one of the pathological diagnostic criteria. However, it is still not entirely clear when these microcirculatory changes appear in the skin of psoriatic subjects. Some studies suggest that capillary dilatation and elongation are present in the clinically uninvolved skin of psoriatic patients even at sites at which psoriatic plaques rarely occur.

OBJECTIVES

To determine, using noninvasive techniques in vivo, the nature of any microvascular changes in the clinically uninvolved skin of psoriatic subjects and to quantify the dermal microvasculature in the clinically uninvolved skin of psoriatic subjects, in vivo.

METHODS

Dermal microvessels in both the clinically uninvolved skin of psoriatic subjects and in the skin of normal volunteers (i.e. individuals without any clinical evidence of psoriasis or other inflammatory dermatoses) were directly visualized by native video-capillaroscopy, in vivo. Images were analysed using a combination of nonstereological and stereological measurements. The findings in each group were then compared to determine if there were any differences in microvascular parameters.

RESULTS

Quantitative analysis of capillaroscopic images showed that there were no significant differences in microvessel density (P = 0.9), image area fraction (P = 0.6), microvessel length density (P = 0.7) and vessel image width (P = 1.0) in the clinically uninvolved skin of psoriatic subjects and the normal skin of healthy volunteers, when extensor forearm skin was examined.

CONCLUSIONS

These findings indicate that prior to the development of clinical lesions there are no significant morphological differences between the dermal microvessels in the clinically uninvolved skin of psoriatic subjects and the dermal microvessels in the normal skin of healthy volunteers. However, during plaque formation, the superficial papillary microvessels in plaque skin undergo a striking, characteristic change, i.e. elongation, widening and tortuosity. These blood vessels must therefore, at least in part, play an important, necessary, but probably secondary role in the pathogenesis of clinical lesions in psoriasis.

Authors+Show Affiliations

Dermatology Unit, St George's Hospital Medical School, Cranmer Terrace, London, UK.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17459047

Citation

Hern, S, and P S. Mortimer. "In Vivo Quantification of Microvessels in Clinically Uninvolved Psoriatic Skin and in Normal Skin." The British Journal of Dermatology, vol. 156, no. 6, 2007, pp. 1224-9.
Hern S, Mortimer PS. In vivo quantification of microvessels in clinically uninvolved psoriatic skin and in normal skin. Br J Dermatol. 2007;156(6):1224-9.
Hern, S., & Mortimer, P. S. (2007). In vivo quantification of microvessels in clinically uninvolved psoriatic skin and in normal skin. The British Journal of Dermatology, 156(6), 1224-9.
Hern S, Mortimer PS. In Vivo Quantification of Microvessels in Clinically Uninvolved Psoriatic Skin and in Normal Skin. Br J Dermatol. 2007;156(6):1224-9. PubMed PMID: 17459047.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - In vivo quantification of microvessels in clinically uninvolved psoriatic skin and in normal skin. AU - Hern,S, AU - Mortimer,P S, Y1 - 2007/04/25/ PY - 2007/4/27/pubmed PY - 2007/9/7/medline PY - 2007/4/27/entrez SP - 1224 EP - 9 JF - The British journal of dermatology JO - Br J Dermatol VL - 156 IS - 6 N2 - BACKGROUND: Microvascular abnormalities (capillary elongation, widening and tortuosity) are a characteristic feature of psoriasis and form one of the pathological diagnostic criteria. However, it is still not entirely clear when these microcirculatory changes appear in the skin of psoriatic subjects. Some studies suggest that capillary dilatation and elongation are present in the clinically uninvolved skin of psoriatic patients even at sites at which psoriatic plaques rarely occur. OBJECTIVES: To determine, using noninvasive techniques in vivo, the nature of any microvascular changes in the clinically uninvolved skin of psoriatic subjects and to quantify the dermal microvasculature in the clinically uninvolved skin of psoriatic subjects, in vivo. METHODS: Dermal microvessels in both the clinically uninvolved skin of psoriatic subjects and in the skin of normal volunteers (i.e. individuals without any clinical evidence of psoriasis or other inflammatory dermatoses) were directly visualized by native video-capillaroscopy, in vivo. Images were analysed using a combination of nonstereological and stereological measurements. The findings in each group were then compared to determine if there were any differences in microvascular parameters. RESULTS: Quantitative analysis of capillaroscopic images showed that there were no significant differences in microvessel density (P = 0.9), image area fraction (P = 0.6), microvessel length density (P = 0.7) and vessel image width (P = 1.0) in the clinically uninvolved skin of psoriatic subjects and the normal skin of healthy volunteers, when extensor forearm skin was examined. CONCLUSIONS: These findings indicate that prior to the development of clinical lesions there are no significant morphological differences between the dermal microvessels in the clinically uninvolved skin of psoriatic subjects and the dermal microvessels in the normal skin of healthy volunteers. However, during plaque formation, the superficial papillary microvessels in plaque skin undergo a striking, characteristic change, i.e. elongation, widening and tortuosity. These blood vessels must therefore, at least in part, play an important, necessary, but probably secondary role in the pathogenesis of clinical lesions in psoriasis. SN - 0007-0963 UR - https://www.unboundmedicine.com/medline/citation/17459047/In_vivo_quantification_of_microvessels_in_clinically_uninvolved_psoriatic_skin_and_in_normal_skin_ L2 - https://doi.org/10.1111/j.1365-2133.2007.07889.x DB - PRIME DP - Unbound Medicine ER -