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Lipid peroxidation and antioxidant status in lichen planus.
Clin Exp Dermatol. 2007 Jul; 32(4):430-4.CE

Abstract

BACKGROUND

Lichen planus (LP) is an inflammatory skin disease of unknown aetiology. Recently, increased oxidative stress has been implicated in the pathogenesis of various skin diseases such as atopic dermatitis, psoriasis vulgaris and vitiligo.

AIM

To evaluate the status of the oxidative stress and antioxidant defence system in patients with LP.

METHODS

In total, 40 patients with LP (23 men, 17 women; mean +/- SD age 43.27 +/- 1.96 years) and 40 control subjects, matched for age and gender, were enrolled in this prospective study. The exclusion criteria included medication with immunosuppressive agents, history of trauma and surgery, and history of alcohol ingestion for at least 1 month prior to the study. The serum nitric oxide (NO), malondialdehyde (MDA) and superoxide dismutase (SOD) levels and the erythrocyte catalase (CAT) levels were investigated in both groups.

RESULTS

Mean +/- SD levels of serum NO (74.60 +/- 17.96 micromol/L) and MDA (18.24 +/- 5.21 micromol/L) in patients with LP were higher than those of the control group (P = 0.007 and P = 0.031, respectively). Serum SOD levels (18.19 +/- 3.71 U/mL) in patients with LP were also higher than in healthy controls (P = 0.002). In contrast, erythrocyte CAT levels (13 557.80 +/- 4134.42 U/kg haemoglobin) were significantly lower in the patient group than in the control group (P = 0.009).

CONCLUSIONS

The findings of this study suggest that increased oxidative stress, increased lipid peroxidation and an imbalance in the antioxidant defence system may be involved in the pathogenesis of LP.

Authors+Show Affiliations

Department of Dermatology, Gaziosmanpasa University School of Medicine, Tokat, Turkey. drensezer@yahoo.com.trNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17459065

Citation

Sezer, E, et al. "Lipid Peroxidation and Antioxidant Status in Lichen Planus." Clinical and Experimental Dermatology, vol. 32, no. 4, 2007, pp. 430-4.
Sezer E, Ozugurlu F, Ozyurt H, et al. Lipid peroxidation and antioxidant status in lichen planus. Clin Exp Dermatol. 2007;32(4):430-4.
Sezer, E., Ozugurlu, F., Ozyurt, H., Sahin, S., & Etikan, I. (2007). Lipid peroxidation and antioxidant status in lichen planus. Clinical and Experimental Dermatology, 32(4), 430-4.
Sezer E, et al. Lipid Peroxidation and Antioxidant Status in Lichen Planus. Clin Exp Dermatol. 2007;32(4):430-4. PubMed PMID: 17459065.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lipid peroxidation and antioxidant status in lichen planus. AU - Sezer,E, AU - Ozugurlu,F, AU - Ozyurt,H, AU - Sahin,S, AU - Etikan,I, Y1 - 2007/04/24/ PY - 2007/4/27/pubmed PY - 2007/10/2/medline PY - 2007/4/27/entrez SP - 430 EP - 4 JF - Clinical and experimental dermatology JO - Clin Exp Dermatol VL - 32 IS - 4 N2 - BACKGROUND: Lichen planus (LP) is an inflammatory skin disease of unknown aetiology. Recently, increased oxidative stress has been implicated in the pathogenesis of various skin diseases such as atopic dermatitis, psoriasis vulgaris and vitiligo. AIM: To evaluate the status of the oxidative stress and antioxidant defence system in patients with LP. METHODS: In total, 40 patients with LP (23 men, 17 women; mean +/- SD age 43.27 +/- 1.96 years) and 40 control subjects, matched for age and gender, were enrolled in this prospective study. The exclusion criteria included medication with immunosuppressive agents, history of trauma and surgery, and history of alcohol ingestion for at least 1 month prior to the study. The serum nitric oxide (NO), malondialdehyde (MDA) and superoxide dismutase (SOD) levels and the erythrocyte catalase (CAT) levels were investigated in both groups. RESULTS: Mean +/- SD levels of serum NO (74.60 +/- 17.96 micromol/L) and MDA (18.24 +/- 5.21 micromol/L) in patients with LP were higher than those of the control group (P = 0.007 and P = 0.031, respectively). Serum SOD levels (18.19 +/- 3.71 U/mL) in patients with LP were also higher than in healthy controls (P = 0.002). In contrast, erythrocyte CAT levels (13 557.80 +/- 4134.42 U/kg haemoglobin) were significantly lower in the patient group than in the control group (P = 0.009). CONCLUSIONS: The findings of this study suggest that increased oxidative stress, increased lipid peroxidation and an imbalance in the antioxidant defence system may be involved in the pathogenesis of LP. SN - 0307-6938 UR - https://www.unboundmedicine.com/medline/citation/17459065/Lipid_peroxidation_and_antioxidant_status_in_lichen_planus_ L2 - https://doi.org/10.1111/j.1365-2230.2007.02436.x DB - PRIME DP - Unbound Medicine ER -