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Dietary macronutrient intake and five-year incident cataract: the blue mountains eye study.

Abstract

PURPOSE

To investigate the relationships between dietary macronutrient intake at baseline and the five-year incidence of the three main types of cataract in older people.

DESIGN

Population-based cohort study.

METHODS

SETTINGS

An urban community near Sydney, Australia.

STUDY POPULATION

The Blue Mountains Eye Study (BMES) examined 3,654 predominantly Caucasian participants aged 49+ years during 1992 to 1994, and then 2,335 survivors (71.5%) after five years. Of these 2,335 subjects, 1988 (85%) completed a Willett-derived food frequency questionnaire (FFQ) at baseline.

OBSERVATION PROCEDURES

A 145-item FFQ was used to assess nutrient intakes and lens photography was used to assess the presence of cataract at both time points.

MAIN OUTCOME MEASURES

Incidence of cortical, nuclear, and posterior subcapsular (PSC) cataract was assessed via lens photographic grading following the Wisconsin cataract grading method.

RESULTS

After adjusting for multiple known cataract risk factors, higher dietary intakes of omega-3 polyunsaturated fatty acids (n-3 PUFA) were associated with a reduced incidence of nuclear cataract. The odds ratio (OR) for subjects in the highest quintile of intake compared to those in the lowest quintile was 0.58 (95% confidence interval [CI] 0.35 to 0.97), P(trend) = .027. Similarly, for PSC cataract, higher dietary intakes of protein were protective (OR 0.28; 95% CI 0.10 to 0.76), P(trend) = .015. Dietary macronutrient intake was not associated with incident cortical cataract.

CONCLUSIONS

Higher dietary intakes of n-3 PUFA may decrease the five-year risk of nuclear cataract, whereas higher dietary intakes of protein may decrease risk for PSC cataract.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Centre for Vision Research, Department of Ophthalmology and the Westmead Millennium Institute, Westmead, Australia.

    , , , , ,

    Source

    American journal of ophthalmology 143:6 2007 Jun pg 932-939

    MeSH

    Aged
    Aged, 80 and over
    Cataract
    Cohort Studies
    Diet
    Diet Records
    Eating
    Fatty Acids, Omega-3
    Female
    Humans
    Incidence
    Male
    Middle Aged
    New South Wales
    Nutrition Assessment
    Nutritional Physiological Phenomena
    Nutritional Status
    Risk Factors
    Urban Population

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    17459316

    Citation

    Townend, Bradley S., et al. "Dietary Macronutrient Intake and Five-year Incident Cataract: the Blue Mountains Eye Study." American Journal of Ophthalmology, vol. 143, no. 6, 2007, pp. 932-939.
    Townend BS, Townend ME, Flood V, et al. Dietary macronutrient intake and five-year incident cataract: the blue mountains eye study. Am J Ophthalmol. 2007;143(6):932-939.
    Townend, B. S., Townend, M. E., Flood, V., Burlutsky, G., Rochtchina, E., Wang, J. J., & Mitchell, P. (2007). Dietary macronutrient intake and five-year incident cataract: the blue mountains eye study. American Journal of Ophthalmology, 143(6), pp. 932-939.
    Townend BS, et al. Dietary Macronutrient Intake and Five-year Incident Cataract: the Blue Mountains Eye Study. Am J Ophthalmol. 2007;143(6):932-939. PubMed PMID: 17459316.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Dietary macronutrient intake and five-year incident cataract: the blue mountains eye study. AU - Townend,Bradley S, AU - Townend,Marcia E, AU - Flood,Victoria, AU - Burlutsky,George, AU - Rochtchina,Elena, AU - Wang,Jie Jin, AU - Mitchell,Paul, Y1 - 2007/04/24/ PY - 2006/09/29/received PY - 2007/01/15/revised PY - 2007/03/08/accepted PY - 2007/4/27/pubmed PY - 2007/6/29/medline PY - 2007/4/27/entrez SP - 932 EP - 939 JF - American journal of ophthalmology JO - Am. J. Ophthalmol. VL - 143 IS - 6 N2 - PURPOSE: To investigate the relationships between dietary macronutrient intake at baseline and the five-year incidence of the three main types of cataract in older people. DESIGN: Population-based cohort study. METHODS: SETTINGS: An urban community near Sydney, Australia. STUDY POPULATION: The Blue Mountains Eye Study (BMES) examined 3,654 predominantly Caucasian participants aged 49+ years during 1992 to 1994, and then 2,335 survivors (71.5%) after five years. Of these 2,335 subjects, 1988 (85%) completed a Willett-derived food frequency questionnaire (FFQ) at baseline. OBSERVATION PROCEDURES: A 145-item FFQ was used to assess nutrient intakes and lens photography was used to assess the presence of cataract at both time points. MAIN OUTCOME MEASURES: Incidence of cortical, nuclear, and posterior subcapsular (PSC) cataract was assessed via lens photographic grading following the Wisconsin cataract grading method. RESULTS: After adjusting for multiple known cataract risk factors, higher dietary intakes of omega-3 polyunsaturated fatty acids (n-3 PUFA) were associated with a reduced incidence of nuclear cataract. The odds ratio (OR) for subjects in the highest quintile of intake compared to those in the lowest quintile was 0.58 (95% confidence interval [CI] 0.35 to 0.97), P(trend) = .027. Similarly, for PSC cataract, higher dietary intakes of protein were protective (OR 0.28; 95% CI 0.10 to 0.76), P(trend) = .015. Dietary macronutrient intake was not associated with incident cortical cataract. CONCLUSIONS: Higher dietary intakes of n-3 PUFA may decrease the five-year risk of nuclear cataract, whereas higher dietary intakes of protein may decrease risk for PSC cataract. SN - 0002-9394 UR - https://www.unboundmedicine.com/medline/citation/17459316/full_citation L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002-9394(07)00245-0 DB - PRIME DP - Unbound Medicine ER -