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Fruit polyphenols and their effects on neuronal signaling and behavior in senescence.
Ann N Y Acad Sci. 2007 Apr; 1100:470-85.AN

Abstract

The onset of age-related neurodegenerative diseases superimposed on a declining nervous system could exacerbate the motor and cognitive behavioral deficits that normally occur in senescence. It is likely that, in cases of severe deficits in memory or motor function, hospitalization and/or custodial care would be a likely outcome. This means that unless some way is found to reduce these age-related decrements in neuronal function, healthcare costs will continue to rise exponentially. Thus, it is extremely important to explore methods to retard or reverse the age-related neuronal deficits as well as their subsequent, behavioral manifestations. Applying molecular biological approaches to slow aging in the human condition may be years away. So it is important to determine what methods can be used today to increase healthy aging, forestall the onset of these diseases, and create conditions favorable to obtaining a "longevity dividend" in both financial and human terms. In this regard, epidemiological studies indicate that consumption of diets rich in antioxidants and anti-inflammatory compounds, such as those found in fruits and vegetables, may lower the risk of developing age-related neurodegenerative diseases, such as Alzheimer's or Parkinson's diseases (AD and PD). Research suggests that the polyphenolic compounds found in fruits, such as blueberries, may exert their beneficial effects by altering stress signaling and neuronal communication, suggesting that interventions may exert protection against age-related deficits in cognitive and motor function. The purpose of this article is to discuss the benefits of these interventions in rodent models and to describe the putative molecular mechanisms involved in their benefits.

Authors+Show Affiliations

Tufts University, Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Rm 919, Boston, MA 02111, USA. james.joseph@tufts.eduNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

17460212

Citation

Joseph, James A., et al. "Fruit Polyphenols and Their Effects On Neuronal Signaling and Behavior in Senescence." Annals of the New York Academy of Sciences, vol. 1100, 2007, pp. 470-85.
Joseph JA, Shukitt-Hale B, Lau FC. Fruit polyphenols and their effects on neuronal signaling and behavior in senescence. Ann N Y Acad Sci. 2007;1100:470-85.
Joseph, J. A., Shukitt-Hale, B., & Lau, F. C. (2007). Fruit polyphenols and their effects on neuronal signaling and behavior in senescence. Annals of the New York Academy of Sciences, 1100, 470-85.
Joseph JA, Shukitt-Hale B, Lau FC. Fruit Polyphenols and Their Effects On Neuronal Signaling and Behavior in Senescence. Ann N Y Acad Sci. 2007;1100:470-85. PubMed PMID: 17460212.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fruit polyphenols and their effects on neuronal signaling and behavior in senescence. AU - Joseph,James A, AU - Shukitt-Hale,Barbara, AU - Lau,Francis C, PY - 2007/4/27/pubmed PY - 2007/5/31/medline PY - 2007/4/27/entrez SP - 470 EP - 85 JF - Annals of the New York Academy of Sciences JO - Ann N Y Acad Sci VL - 1100 N2 - The onset of age-related neurodegenerative diseases superimposed on a declining nervous system could exacerbate the motor and cognitive behavioral deficits that normally occur in senescence. It is likely that, in cases of severe deficits in memory or motor function, hospitalization and/or custodial care would be a likely outcome. This means that unless some way is found to reduce these age-related decrements in neuronal function, healthcare costs will continue to rise exponentially. Thus, it is extremely important to explore methods to retard or reverse the age-related neuronal deficits as well as their subsequent, behavioral manifestations. Applying molecular biological approaches to slow aging in the human condition may be years away. So it is important to determine what methods can be used today to increase healthy aging, forestall the onset of these diseases, and create conditions favorable to obtaining a "longevity dividend" in both financial and human terms. In this regard, epidemiological studies indicate that consumption of diets rich in antioxidants and anti-inflammatory compounds, such as those found in fruits and vegetables, may lower the risk of developing age-related neurodegenerative diseases, such as Alzheimer's or Parkinson's diseases (AD and PD). Research suggests that the polyphenolic compounds found in fruits, such as blueberries, may exert their beneficial effects by altering stress signaling and neuronal communication, suggesting that interventions may exert protection against age-related deficits in cognitive and motor function. The purpose of this article is to discuss the benefits of these interventions in rodent models and to describe the putative molecular mechanisms involved in their benefits. SN - 0077-8923 UR - https://www.unboundmedicine.com/medline/citation/17460212/Fruit_polyphenols_and_their_effects_on_neuronal_signaling_and_behavior_in_senescence_ L2 - https://doi.org/10.1196/annals.1395.052 DB - PRIME DP - Unbound Medicine ER -