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Distinctive cytogenetic profile in benign metastasizing leiomyoma: pathogenetic implications.
Am J Surg Pathol. 2007 May; 31(5):737-43.AJ

Abstract

"Benign metastasizing leiomyoma" is the terminology used to describe a controversial entity characterized by a proliferation of bland-appearing smooth muscle in lung or abdominopelvic lymph nodes. In this report, we describe 5 cases of pulmonary-based smooth muscle tumors that are clinically and histologically consistent with this entity, and in which we identified consistent chromosomal aberrations (19q and 22q terminal deletion in all cases). This cytogenetic profile is found in approximately 3% of uterine leiomyoma, but has not been described in other types of benign or malignant neoplasia. These findings suggest that the nodular pulmonary smooth muscle proliferations termed "benign metastasizing leiomyoma," are a genetically distinct entity, which likely originate from a biologically distinctive subset of uterine leiomyoma.

Authors+Show Affiliations

Department of Pathology, Divisions of Women's and Perinatal Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. mnucci@partners.orgNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

17460458

Citation

Nucci, Marisa R., et al. "Distinctive Cytogenetic Profile in Benign Metastasizing Leiomyoma: Pathogenetic Implications." The American Journal of Surgical Pathology, vol. 31, no. 5, 2007, pp. 737-43.
Nucci MR, Drapkin R, Dal Cin P, et al. Distinctive cytogenetic profile in benign metastasizing leiomyoma: pathogenetic implications. Am J Surg Pathol. 2007;31(5):737-43.
Nucci, M. R., Drapkin, R., Dal Cin, P., Fletcher, C. D., & Fletcher, J. A. (2007). Distinctive cytogenetic profile in benign metastasizing leiomyoma: pathogenetic implications. The American Journal of Surgical Pathology, 31(5), 737-43.
Nucci MR, et al. Distinctive Cytogenetic Profile in Benign Metastasizing Leiomyoma: Pathogenetic Implications. Am J Surg Pathol. 2007;31(5):737-43. PubMed PMID: 17460458.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Distinctive cytogenetic profile in benign metastasizing leiomyoma: pathogenetic implications. AU - Nucci,Marisa R, AU - Drapkin,Ronny, AU - Dal Cin,Paola, AU - Fletcher,Christopher D M, AU - Fletcher,Jonathan A, PY - 2007/4/27/pubmed PY - 2007/6/1/medline PY - 2007/4/27/entrez SP - 737 EP - 43 JF - The American journal of surgical pathology JO - Am. J. Surg. Pathol. VL - 31 IS - 5 N2 - "Benign metastasizing leiomyoma" is the terminology used to describe a controversial entity characterized by a proliferation of bland-appearing smooth muscle in lung or abdominopelvic lymph nodes. In this report, we describe 5 cases of pulmonary-based smooth muscle tumors that are clinically and histologically consistent with this entity, and in which we identified consistent chromosomal aberrations (19q and 22q terminal deletion in all cases). This cytogenetic profile is found in approximately 3% of uterine leiomyoma, but has not been described in other types of benign or malignant neoplasia. These findings suggest that the nodular pulmonary smooth muscle proliferations termed "benign metastasizing leiomyoma," are a genetically distinct entity, which likely originate from a biologically distinctive subset of uterine leiomyoma. SN - 0147-5185 UR - https://www.unboundmedicine.com/medline/citation/17460458/Distinctive_cytogenetic_profile_in_benign_metastasizing_leiomyoma:_pathogenetic_implications_ L2 - http://dx.doi.org/10.1097/01.pas.0000213414.15633.4e DB - PRIME DP - Unbound Medicine ER -