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[Risk factors for cardiovascular diseases: what is the role for homocysteine?].
G Ital Cardiol (Rome). 2007 Mar; 8(3):148-60.GI

Abstract

Cardiovascular diseases are commonly related to classical risk factors, but other risk markers have been identified, including homocysteine. Homocysteine is a sulphurated amino acid which derives from methionine. The causes of hyperhomocysteinemia are multifactorial, such as genetic defects, pathophysiological conditions, lifestyle and drugs-related. Hyperhomocysteinemia favors atherothrombosis through endothelial dysfunction, enhancement of inflammation and thrombophilic profile. A number of clinical and laboratory trials exist regarding the association between homocysteine levels and an increased risk of cardiovascular disease. However, the lack of homogeneity in the data, together with the high number of factors capable of influencing homocysteine plasma levels, and the disappointing results of therapeutic trials do not permit us at present to consider homocysteine as an independent and major risk factor for cardiovascular disease.

Authors+Show Affiliations

U.O. di Cardiologia, Ospedale S. Maria della Stella, Orvieto, TR. bendini.mg@tiscalinet.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Review

Language

ita

PubMed ID

17461357

Citation

Bendini, Maria Grazia, et al. "[Risk Factors for Cardiovascular Diseases: what Is the Role for Homocysteine?]." Giornale Italiano Di Cardiologia (2006), vol. 8, no. 3, 2007, pp. 148-60.
Bendini MG, Lanza GA, Mazza A, et al. [Risk factors for cardiovascular diseases: what is the role for homocysteine?]. G Ital Cardiol (Rome). 2007;8(3):148-60.
Bendini, M. G., Lanza, G. A., Mazza, A., Giordano, A., Leggio, M., Menichini, G., De Cristofaro, R., Moriconi, E., Cozzari, L., Farina, S. M., & Giordano, G. (2007). [Risk factors for cardiovascular diseases: what is the role for homocysteine?]. Giornale Italiano Di Cardiologia (2006), 8(3), 148-60.
Bendini MG, et al. [Risk Factors for Cardiovascular Diseases: what Is the Role for Homocysteine?]. G Ital Cardiol (Rome). 2007;8(3):148-60. PubMed PMID: 17461357.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Risk factors for cardiovascular diseases: what is the role for homocysteine?]. AU - Bendini,Maria Grazia, AU - Lanza,Gaetano Antonio, AU - Mazza,Andrea, AU - Giordano,Andrea, AU - Leggio,Massimo, AU - Menichini,Giulio, AU - De Cristofaro,Raffaele, AU - Moriconi,Emanuela, AU - Cozzari,Laura, AU - Farina,Sergio Maria, AU - Giordano,Giampiero, PY - 2007/4/28/pubmed PY - 2007/6/15/medline PY - 2007/4/28/entrez SP - 148 EP - 60 JF - Giornale italiano di cardiologia (2006) JO - G Ital Cardiol (Rome) VL - 8 IS - 3 N2 - Cardiovascular diseases are commonly related to classical risk factors, but other risk markers have been identified, including homocysteine. Homocysteine is a sulphurated amino acid which derives from methionine. The causes of hyperhomocysteinemia are multifactorial, such as genetic defects, pathophysiological conditions, lifestyle and drugs-related. Hyperhomocysteinemia favors atherothrombosis through endothelial dysfunction, enhancement of inflammation and thrombophilic profile. A number of clinical and laboratory trials exist regarding the association between homocysteine levels and an increased risk of cardiovascular disease. However, the lack of homogeneity in the data, together with the high number of factors capable of influencing homocysteine plasma levels, and the disappointing results of therapeutic trials do not permit us at present to consider homocysteine as an independent and major risk factor for cardiovascular disease. SN - 1827-6806 UR - https://www.unboundmedicine.com/medline/citation/17461357/[Risk_factors_for_cardiovascular_diseases:_what_is_the_role_for_homocysteine]_ DB - PRIME DP - Unbound Medicine ER -