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Prevalence of coeliac disease in patients with autoimmune thyroiditis in a Turkish population.

Abstract

AIM

To investigate the prevalence of coeliac disease in a series of Turkish patients with autoimmune thyroiditis.

METHODS

Sera from 136 consecutive patients with newly diagnosed autoimmune thyroiditis and 119 healthy blood donors were tested for IgA tissue transglutaminase antibody with enzyme-linked immunosorbent assay. Endoscopic mucosal biopsy from the second part of duodenum was performed in patients with positive antibody test.

RESULTS

Eight patients (5.9%) and one control subject (0.8%) were positive for IgA tissue transglutaminase antibody (OR: 7.38, 95% CI: 0.91-59.85, P = 0.04). Six patients and one control agreed to take biopsies. Histopathological examination revealed changes classified as Marsh IIIa in one, Marsh II in one, Marsh I in two, and Marsh 0 in two patients with autoimmune throiditis, and Marsh I in one blood donor.

CONCLUSION

Turkish patients with autoimmune thyroiditis have an increased risk of coeliac disease and serological screening may be useful for early detection of coeliac disease in these patients. Our findings need to be confirmed in a larger series of patients.

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  • Authors+Show Affiliations

    ,

    Section of Gastroenterology, Department of Internal Medicine, Kirikkale University, Kirikkale, Turkey. sguliter@yahoo.com

    , , , , ,

    Source

    World journal of gastroenterology 13:10 2007 Mar 14 pg 1599-601

    MeSH

    Adolescent
    Adult
    Aged
    Biopsy
    Case-Control Studies
    Celiac Disease
    Duodenum
    Female
    Humans
    Immunoglobulin A
    Male
    Middle Aged
    Prevalence
    Risk Factors
    Thyroiditis, Autoimmune
    Turkey

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    17461455

    Citation

    Guliter, Sefa, et al. "Prevalence of Coeliac Disease in Patients With Autoimmune Thyroiditis in a Turkish Population." World Journal of Gastroenterology, vol. 13, no. 10, 2007, pp. 1599-601.
    Guliter S, Yakaryilmaz F, Ozkurt Z, et al. Prevalence of coeliac disease in patients with autoimmune thyroiditis in a Turkish population. World J Gastroenterol. 2007;13(10):1599-601.
    Guliter, S., Yakaryilmaz, F., Ozkurt, Z., Ersoy, R., Ucardag, D., Caglayan, O., & Atasoy, P. (2007). Prevalence of coeliac disease in patients with autoimmune thyroiditis in a Turkish population. World Journal of Gastroenterology, 13(10), pp. 1599-601.
    Guliter S, et al. Prevalence of Coeliac Disease in Patients With Autoimmune Thyroiditis in a Turkish Population. World J Gastroenterol. 2007 Mar 14;13(10):1599-601. PubMed PMID: 17461455.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Prevalence of coeliac disease in patients with autoimmune thyroiditis in a Turkish population. AU - Guliter,Sefa, AU - Yakaryilmaz,Fahri, AU - Ozkurt,Zubeyde, AU - Ersoy,Reyhan, AU - Ucardag,Derya, AU - Caglayan,Osman, AU - Atasoy,Pinar, PY - 2007/4/28/pubmed PY - 2007/6/6/medline PY - 2007/4/28/entrez SP - 1599 EP - 601 JF - World journal of gastroenterology JO - World J. Gastroenterol. VL - 13 IS - 10 N2 - AIM: To investigate the prevalence of coeliac disease in a series of Turkish patients with autoimmune thyroiditis. METHODS: Sera from 136 consecutive patients with newly diagnosed autoimmune thyroiditis and 119 healthy blood donors were tested for IgA tissue transglutaminase antibody with enzyme-linked immunosorbent assay. Endoscopic mucosal biopsy from the second part of duodenum was performed in patients with positive antibody test. RESULTS: Eight patients (5.9%) and one control subject (0.8%) were positive for IgA tissue transglutaminase antibody (OR: 7.38, 95% CI: 0.91-59.85, P = 0.04). Six patients and one control agreed to take biopsies. Histopathological examination revealed changes classified as Marsh IIIa in one, Marsh II in one, Marsh I in two, and Marsh 0 in two patients with autoimmune throiditis, and Marsh I in one blood donor. CONCLUSION: Turkish patients with autoimmune thyroiditis have an increased risk of coeliac disease and serological screening may be useful for early detection of coeliac disease in these patients. Our findings need to be confirmed in a larger series of patients. SN - 1007-9327 UR - https://www.unboundmedicine.com/medline/citation/17461455/Prevalence_of_coeliac_disease_in_patients_with_autoimmune_thyroiditis_in_a_Turkish_population_ L2 - http://www.wjgnet.com/1007-9327/full/v13/i10/1599.htm DB - PRIME DP - Unbound Medicine ER -