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Improved virological response to highly active antiretroviral therapy in HIV-1-infected patients carrying the CCR5 Delta32 deletion.
HIV Med. 2007 May; 8(4):213-9.HM

Abstract

BACKGROUND

Patients heterozygous for the C-C chemokine receptor 5 (CCR5) Delta32 deletion spontaneously progress less rapidly to AIDS and death than do wild-type patients. We investigated whether the CCR5 Delta32 deletion has an impact on immunological, virological and clinical responses to highly active antiretroviral therapy (HAART) in HIV-1-infected patients.

PATIENTS AND METHODS

We included in the study 565 HIV-1-infected patients from the French HIV-1 infected cohort with documented date of seroconversion (SEROCO)/haemophiliacs HIV-1 infected (HEMOCO) cohorts, who started HAART after 1996. We investigated virological responses to HAART at 6 months (defined as a plasma HIV-1 RNA measurement below the threshold of detection or a 2 log HIV-1 RNA decrease) and at 12 months (defined as a plasma HIV-1 RNA measurement below the threshold of detection) and clinical response to HAART by Kaplan-Meier survival curves, with AIDS and death as outcomes.

RESULTS

The Delta32 heterozygous patients (n=83; 15%) had a better virological response to HAART than wild-type patients (73 vs 53% at 6 months, P=0.01; and 60 vs 44% at 12 months, P=0.01). This better virological response was still observed after adjustment for antiretroviral status (whether or not patients were naïve to antiretroviral therapy), year of HAART initiation, number of new antiretroviral drugs and baseline viral load. There was no statistical difference between heterozygous patients and wild-type patients in terms of survival and AIDS-free survival.

CONCLUSIONS

CCR5 Delta32 heterozygous patients were more likely to have a virological response to HAART than wild-type patients at 6 and 12 months. However, this virological response did not produce better immunological and clinical responses. The long-term impact of the Delta32 deletion on survival in HIV-1-infected treated patients should be investigated in a meta-analysis.

Authors+Show Affiliations

INSERM, U569, Hôpital Bicêtre, Faculté de Médecine Paris-Sud, Le Kremlin-Bicêtre, France. jean-jacques.laurichesse@bch.aphp.frNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17461848

Citation

Laurichesse, J J., et al. "Improved Virological Response to Highly Active Antiretroviral Therapy in HIV-1-infected Patients Carrying the CCR5 Delta32 Deletion." HIV Medicine, vol. 8, no. 4, 2007, pp. 213-9.
Laurichesse JJ, Persoz A, Theodorou I, et al. Improved virological response to highly active antiretroviral therapy in HIV-1-infected patients carrying the CCR5 Delta32 deletion. HIV Med. 2007;8(4):213-9.
Laurichesse, J. J., Persoz, A., Theodorou, I., Rouzioux, C., Delfraissy, J. F., & Meyer, L. (2007). Improved virological response to highly active antiretroviral therapy in HIV-1-infected patients carrying the CCR5 Delta32 deletion. HIV Medicine, 8(4), 213-9.
Laurichesse JJ, et al. Improved Virological Response to Highly Active Antiretroviral Therapy in HIV-1-infected Patients Carrying the CCR5 Delta32 Deletion. HIV Med. 2007;8(4):213-9. PubMed PMID: 17461848.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Improved virological response to highly active antiretroviral therapy in HIV-1-infected patients carrying the CCR5 Delta32 deletion. AU - Laurichesse,J J, AU - Persoz,A, AU - Theodorou,I, AU - Rouzioux,C, AU - Delfraissy,J F, AU - Meyer,L, PY - 2007/4/28/pubmed PY - 2007/12/21/medline PY - 2007/4/28/entrez SP - 213 EP - 9 JF - HIV medicine JO - HIV Med. VL - 8 IS - 4 N2 - BACKGROUND: Patients heterozygous for the C-C chemokine receptor 5 (CCR5) Delta32 deletion spontaneously progress less rapidly to AIDS and death than do wild-type patients. We investigated whether the CCR5 Delta32 deletion has an impact on immunological, virological and clinical responses to highly active antiretroviral therapy (HAART) in HIV-1-infected patients. PATIENTS AND METHODS: We included in the study 565 HIV-1-infected patients from the French HIV-1 infected cohort with documented date of seroconversion (SEROCO)/haemophiliacs HIV-1 infected (HEMOCO) cohorts, who started HAART after 1996. We investigated virological responses to HAART at 6 months (defined as a plasma HIV-1 RNA measurement below the threshold of detection or a 2 log HIV-1 RNA decrease) and at 12 months (defined as a plasma HIV-1 RNA measurement below the threshold of detection) and clinical response to HAART by Kaplan-Meier survival curves, with AIDS and death as outcomes. RESULTS: The Delta32 heterozygous patients (n=83; 15%) had a better virological response to HAART than wild-type patients (73 vs 53% at 6 months, P=0.01; and 60 vs 44% at 12 months, P=0.01). This better virological response was still observed after adjustment for antiretroviral status (whether or not patients were naïve to antiretroviral therapy), year of HAART initiation, number of new antiretroviral drugs and baseline viral load. There was no statistical difference between heterozygous patients and wild-type patients in terms of survival and AIDS-free survival. CONCLUSIONS: CCR5 Delta32 heterozygous patients were more likely to have a virological response to HAART than wild-type patients at 6 and 12 months. However, this virological response did not produce better immunological and clinical responses. The long-term impact of the Delta32 deletion on survival in HIV-1-infected treated patients should be investigated in a meta-analysis. SN - 1464-2662 UR - https://www.unboundmedicine.com/medline/citation/17461848/Improved_virological_response_to_highly_active_antiretroviral_therapy_in_HIV_1_infected_patients_carrying_the_CCR5_Delta32_deletion_ L2 - https://doi.org/10.1111/j.1468-1293.2007.00455.x DB - PRIME DP - Unbound Medicine ER -