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Vitamin D inadequacy in Belgian postmenopausal osteoporotic women.
BMC Public Health. 2007 Apr 26; 7:64.BP

Abstract

BACKGROUND

Inadequate serum vitamin D [25(OH)D] concentrations are associated with secondary hyperparathyroidism, increased bone turnover and bone loss, which increase fracture risk. The objective of this study is to assess the prevalence of inadequate serum 25(OH)D concentrations in postmenopausal Belgian women. Opinions with regard to the definition of vitamin D deficiency and adequate vitamin D status vary widely and there are no clear international agreements on what constitute adequate concentrations of vitamin D.

METHODS

Assessment of 25-hydroxyvitamin D [25(OH)D] and parathyroid hormone was performed in 1195 Belgian postmenopausal women aged over 50 years. Main analysis has been performed in the whole study population and according to the previous use of vitamin D and calcium supplements. Four cut-offs of 25(OH)D inadequacy were fixed : < 80 nmol/L, <75 nmol/L, < 50 nmol/L and < 30 nmol/L.

RESULTS

Mean (SD) age of the patients was 76.9 (7.5) years, body mass index was 25.7 (4.5) kg/m2. Concentrations of 25(OH)D were 52.5 (21.4) nmol/L. In the whole study population, the prevalence of 25(OH)D inadequacy was 91.3 %, 87.5 %, 43.1 % and 15.9% when considering cut-offs of 80, 75, 50 and 30 nmol/L, respectively. Women who used vitamin D supplements, alone or combined with calcium supplements, had higher concentrations of 25(OH)D than non-users. Significant inverse correlations were found between age/serum PTH and serum 25(OH)D (r = -0.23/r = -0.31) and also between age/serum PTH and femoral neck BMD (r = -0.29/r = -0.15). There is a significant positive relation between age and PTH (r = 0.16), serum 25(OH)D and femoral neck BMD (r = 0.07). (P < 0.05)Vitamin D concentrations varied with the season of sampling but did not reach statistical significance (P = 0.09).

CONCLUSION

This study points out a high prevalence of vitamin D inadequacy in Belgian postmenopausal osteoporotic women, even among subjects receiving vitamin D supplements.

Authors+Show Affiliations

Department of Epidemiology, Public Health and Health Economics, University of Liege, 4020 Liege, Belgium. Audrey.Neuprez@student.ulg.ac.be <Audrey.Neuprez@student.ulg.ac.be>No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17462085

Citation

Neuprez, Audrey, et al. "Vitamin D Inadequacy in Belgian Postmenopausal Osteoporotic Women." BMC Public Health, vol. 7, 2007, p. 64.
Neuprez A, Bruyère O, Collette J, et al. Vitamin D inadequacy in Belgian postmenopausal osteoporotic women. BMC Public Health. 2007;7:64.
Neuprez, A., Bruyère, O., Collette, J., & Reginster, J. Y. (2007). Vitamin D inadequacy in Belgian postmenopausal osteoporotic women. BMC Public Health, 7, 64.
Neuprez A, et al. Vitamin D Inadequacy in Belgian Postmenopausal Osteoporotic Women. BMC Public Health. 2007 Apr 26;7:64. PubMed PMID: 17462085.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vitamin D inadequacy in Belgian postmenopausal osteoporotic women. AU - Neuprez,Audrey, AU - Bruyère,Olivier, AU - Collette,Julien, AU - Reginster,Jean-Yves, Y1 - 2007/04/26/ PY - 2006/10/25/received PY - 2007/04/26/accepted PY - 2007/4/28/pubmed PY - 2007/6/6/medline PY - 2007/4/28/entrez SP - 64 EP - 64 JF - BMC public health JO - BMC Public Health VL - 7 N2 - BACKGROUND: Inadequate serum vitamin D [25(OH)D] concentrations are associated with secondary hyperparathyroidism, increased bone turnover and bone loss, which increase fracture risk. The objective of this study is to assess the prevalence of inadequate serum 25(OH)D concentrations in postmenopausal Belgian women. Opinions with regard to the definition of vitamin D deficiency and adequate vitamin D status vary widely and there are no clear international agreements on what constitute adequate concentrations of vitamin D. METHODS: Assessment of 25-hydroxyvitamin D [25(OH)D] and parathyroid hormone was performed in 1195 Belgian postmenopausal women aged over 50 years. Main analysis has been performed in the whole study population and according to the previous use of vitamin D and calcium supplements. Four cut-offs of 25(OH)D inadequacy were fixed : < 80 nmol/L, <75 nmol/L, < 50 nmol/L and < 30 nmol/L. RESULTS: Mean (SD) age of the patients was 76.9 (7.5) years, body mass index was 25.7 (4.5) kg/m2. Concentrations of 25(OH)D were 52.5 (21.4) nmol/L. In the whole study population, the prevalence of 25(OH)D inadequacy was 91.3 %, 87.5 %, 43.1 % and 15.9% when considering cut-offs of 80, 75, 50 and 30 nmol/L, respectively. Women who used vitamin D supplements, alone or combined with calcium supplements, had higher concentrations of 25(OH)D than non-users. Significant inverse correlations were found between age/serum PTH and serum 25(OH)D (r = -0.23/r = -0.31) and also between age/serum PTH and femoral neck BMD (r = -0.29/r = -0.15). There is a significant positive relation between age and PTH (r = 0.16), serum 25(OH)D and femoral neck BMD (r = 0.07). (P < 0.05)Vitamin D concentrations varied with the season of sampling but did not reach statistical significance (P = 0.09). CONCLUSION: This study points out a high prevalence of vitamin D inadequacy in Belgian postmenopausal osteoporotic women, even among subjects receiving vitamin D supplements. SN - 1471-2458 UR - https://www.unboundmedicine.com/medline/citation/17462085/Vitamin_D_inadequacy_in_Belgian_postmenopausal_osteoporotic_women_ L2 - https://bmcpublichealth.biomedcentral.com/articles/10.1186/1471-2458-7-64 DB - PRIME DP - Unbound Medicine ER -