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Therapeutic effects of hyperbaric oxygen in a rat model of endothelin-1-induced focal cerebral ischemia.
Brain Res. 2007 Jun 11; 1153:204-13.BR

Abstract

It has been established that hyperbaric oxygen (HBO) treatment reduces brain edema, decreases infarct volume, contributes to neurological functional recovery and suppresses apoptosis in suture-induced focal cerebral ischemic animal models. In the present study, we evaluated the therapeutic effect of HBO in an endothelin-1-induced focal cerebral ischemia in rats and explored the associated mechanisms of HBO-induced brain protection. One hundred twenty male Sprague-Dawley rats (280 to 320 g) were randomly assigned to sham, focal cerebral ischemia and focal cerebral ischemia treated with HBO groups. Brain water content, neurological function, morphology and molecular biological markers were assessed. HBO (100% O2, 2.5 atmosphere absolute for 2 h) was initiated at 1 h after focal cerebral ischemia. Rats were killed at 24 h to harvest tissues for Western blot or for histology. In HBO-treated animals, an enhanced ratio of Bcl-2 and Bax and a reduced expression of hypoxia-inducible factor-1alpha (HIF-1alpha) in the hippocampus after focal cerebral ischemia were observed. These results indicate that HBO provides brain protection that is probably associated with the inhibition of HIF-1alpha and the elevation of Bcl-2.

Authors+Show Affiliations

Department of Diving Medicine, Faculty of Naval Medicine, Second Military Medical University, Shanghai, 200433, PR China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17462608

Citation

Huang, Zhen-Xing, et al. "Therapeutic Effects of Hyperbaric Oxygen in a Rat Model of Endothelin-1-induced Focal Cerebral Ischemia." Brain Research, vol. 1153, 2007, pp. 204-13.
Huang ZX, Kang ZM, Gu GJ, et al. Therapeutic effects of hyperbaric oxygen in a rat model of endothelin-1-induced focal cerebral ischemia. Brain Res. 2007;1153:204-13.
Huang, Z. X., Kang, Z. M., Gu, G. J., Peng, G. N., Yun, L., Tao, H. Y., Xu, W. G., Sun, X. J., & Zhang, J. H. (2007). Therapeutic effects of hyperbaric oxygen in a rat model of endothelin-1-induced focal cerebral ischemia. Brain Research, 1153, 204-13.
Huang ZX, et al. Therapeutic Effects of Hyperbaric Oxygen in a Rat Model of Endothelin-1-induced Focal Cerebral Ischemia. Brain Res. 2007 Jun 11;1153:204-13. PubMed PMID: 17462608.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Therapeutic effects of hyperbaric oxygen in a rat model of endothelin-1-induced focal cerebral ischemia. AU - Huang,Zhen-Xing, AU - Kang,Zhi-Min, AU - Gu,Guo-Jun, AU - Peng,Guang-Neng, AU - Yun,Liu, AU - Tao,Heng-Yi, AU - Xu,Wei-Gang, AU - Sun,Xue-Jun, AU - Zhang,John H, Y1 - 2007/03/28/ PY - 2007/01/25/received PY - 2007/03/20/revised PY - 2007/03/21/accepted PY - 2007/4/28/pubmed PY - 2008/1/10/medline PY - 2007/4/28/entrez SP - 204 EP - 13 JF - Brain research JO - Brain Res. VL - 1153 N2 - It has been established that hyperbaric oxygen (HBO) treatment reduces brain edema, decreases infarct volume, contributes to neurological functional recovery and suppresses apoptosis in suture-induced focal cerebral ischemic animal models. In the present study, we evaluated the therapeutic effect of HBO in an endothelin-1-induced focal cerebral ischemia in rats and explored the associated mechanisms of HBO-induced brain protection. One hundred twenty male Sprague-Dawley rats (280 to 320 g) were randomly assigned to sham, focal cerebral ischemia and focal cerebral ischemia treated with HBO groups. Brain water content, neurological function, morphology and molecular biological markers were assessed. HBO (100% O2, 2.5 atmosphere absolute for 2 h) was initiated at 1 h after focal cerebral ischemia. Rats were killed at 24 h to harvest tissues for Western blot or for histology. In HBO-treated animals, an enhanced ratio of Bcl-2 and Bax and a reduced expression of hypoxia-inducible factor-1alpha (HIF-1alpha) in the hippocampus after focal cerebral ischemia were observed. These results indicate that HBO provides brain protection that is probably associated with the inhibition of HIF-1alpha and the elevation of Bcl-2. SN - 0006-8993 UR - https://www.unboundmedicine.com/medline/citation/17462608/Therapeutic_effects_of_hyperbaric_oxygen_in_a_rat_model_of_endothelin_1_induced_focal_cerebral_ischemia_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0006-8993(07)00731-7 DB - PRIME DP - Unbound Medicine ER -