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Comparative analysis of zinc protoporphyrin and blood lead levels in lead-exposed Andean children.
Clin Biochem. 2007 Jul; 40(11):787-92.CB

Abstract

OBJECTIVES

The objective of this study was to investigate the zinc protoporphyrin/heme ratio (ZPP/heme) as a biomarker for chronic lead (Pb) poisoning in children with a history of high Pb exposure.

DESIGN AND METHODS

ZPP/heme ratio was measured in blood samples from 78 children (44 females and 34 males) with persistent Pb exposure from Pb glazing of ceramics in a local cottage industry in the Andes Mountains of Ecuador.

RESULTS

Mean blood lead (PbB) level was 26.4 microg/dL (SD: 23.2; range: 4.0-107.0), and the mean ZPP/heme ratio was 152.4 micromol/mol (SD: 190.6; range: 36.0-1064.0). A regression analysis of PbB level and ZPP/heme ratio revealed a significant association (r=0.761, p= <0.0001), with the logZPP showing a higher correlation with PbB (r=0.869, p= <0.0001). The ZZP/heme ratio decreased significantly with increasing age (ANOVA, p=0.030). The mean ZPP/heme ratios for females and males were 139.6 and 169.0 micromol/mol, respectively, and were not statistically different (t-test, p=0.504).

CONCLUSION

The elevated ZPP/heme ratios, coupled with high PbB levels observed in this cohort of Andean children of Pb-glazing workers, suggest chronic Pb intoxication and probable iron deficiency.

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Authors+Show Affiliations

Counter SA
Department of Neurology, Harvard Medical School/The Biological Laboratories, Cambridge, MA 02138, USA. allen_counter@harvard.edu
Buchanan LH
No affiliation info available
Ortega F
No affiliation info available
Rifai N
No affiliation info available
Shannon MW
No affiliation info available

MeSH

AdolescentAge DistributionChildChild, PreschoolEcuadorFemaleHemeHumansInfantLeadLead PoisoningMaleProtoporphyrins

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

17462618

Citation

Counter, S Allen, et al. "Comparative Analysis of Zinc Protoporphyrin and Blood Lead Levels in Lead-exposed Andean Children." Clinical Biochemistry, vol. 40, no. 11, 2007, pp. 787-92.
Counter SA, Buchanan LH, Ortega F, et al. Comparative analysis of zinc protoporphyrin and blood lead levels in lead-exposed Andean children. Clin Biochem. 2007;40(11):787-92.
Counter, S. A., Buchanan, L. H., Ortega, F., Rifai, N., & Shannon, M. W. (2007). Comparative analysis of zinc protoporphyrin and blood lead levels in lead-exposed Andean children. Clinical Biochemistry, 40(11), 787-92.
Counter SA, et al. Comparative Analysis of Zinc Protoporphyrin and Blood Lead Levels in Lead-exposed Andean Children. Clin Biochem. 2007;40(11):787-92. PubMed PMID: 17462618.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparative analysis of zinc protoporphyrin and blood lead levels in lead-exposed Andean children. AU - Counter,S Allen, AU - Buchanan,Leo H, AU - Ortega,Fernando, AU - Rifai,Nader, AU - Shannon,Michael W, Y1 - 2007/03/16/ PY - 2007/01/06/received PY - 2007/03/03/revised PY - 2007/03/07/accepted PY - 2007/4/28/pubmed PY - 2007/8/19/medline PY - 2007/4/28/entrez SP - 787 EP - 92 JF - Clinical biochemistry JO - Clin Biochem VL - 40 IS - 11 N2 - OBJECTIVES: The objective of this study was to investigate the zinc protoporphyrin/heme ratio (ZPP/heme) as a biomarker for chronic lead (Pb) poisoning in children with a history of high Pb exposure. DESIGN AND METHODS: ZPP/heme ratio was measured in blood samples from 78 children (44 females and 34 males) with persistent Pb exposure from Pb glazing of ceramics in a local cottage industry in the Andes Mountains of Ecuador. RESULTS: Mean blood lead (PbB) level was 26.4 microg/dL (SD: 23.2; range: 4.0-107.0), and the mean ZPP/heme ratio was 152.4 micromol/mol (SD: 190.6; range: 36.0-1064.0). A regression analysis of PbB level and ZPP/heme ratio revealed a significant association (r=0.761, p= <0.0001), with the logZPP showing a higher correlation with PbB (r=0.869, p= <0.0001). The ZZP/heme ratio decreased significantly with increasing age (ANOVA, p=0.030). The mean ZPP/heme ratios for females and males were 139.6 and 169.0 micromol/mol, respectively, and were not statistically different (t-test, p=0.504). CONCLUSION: The elevated ZPP/heme ratios, coupled with high PbB levels observed in this cohort of Andean children of Pb-glazing workers, suggest chronic Pb intoxication and probable iron deficiency. SN - 0009-9120 UR - https://www.unboundmedicine.com/medline/citation/17462618/Comparative_analysis_of_zinc_protoporphyrin_and_blood_lead_levels_in_lead_exposed_Andean_children_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0009-9120(07)00127-0 DB - PRIME DP - Unbound Medicine ER -