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Apolipoprotein E polymorphism is associated with both carotid and coronary atherosclerosis in patients with coronary artery disease.
Nutr Metab Cardiovasc Dis. 2008 May; 18(4):271-7.NM

Abstract

BACKGROUND AND AIMS

Apolipoprotein E (apoE) polymorphism plays a significant role in the development of atherosclerosis and cardiovascular disease. Therefore, the aim of the present study was to examine the association between apoE polymorphism and carotid intima-media thickness (IMT), and severity and extent of coronary artery disease (CAD).

METHODS AND RESULTS

B-mode ultrasound and quantitative coronary angiography (QCA) were used to assess carotid, and coronary artery atherosclerosis in 91 patients with clinically suspected CAD referred for cardiac catheterization. Two apoE phenotype groups were defined: apoE3 (E3/E3) and apoE4 (including E4/E3, E4/E4 phenotypes). Maximum IMT was higher in the apoE4 group than in the apoE3 group (p=0.022). The global atheroma burden index was similarly higher in the apoE4 group than in the apoE3 group (p=0.033). ApoE4 subjects had higher levels of apolipoprotein B (apoB) (p=0.008), triglycerides (p=0.006), remnant lipoprotein-cholesterol (RLP-C) (p=0.023), and lipoprotein(a) [(Lp(a)] (p=0.041) than apoE3 subjects. The mean LDL particle size was smaller in the apoE4 group than in the apoE3 group (p=0.041).

CONCLUSIONS

ApoE polymorphism was associated with both carotid and coronary atherosclerosis. Patients with the apoE4 isoform had an increased carotid IMT and a more severe and extensive CAD than patients with the apoE3 isoform.

Authors+Show Affiliations

Department of Internal Medicine, Division of Cardiology, Helsinki University Central Hospital, Haartmaninkatu 4, FIN-00290 HUCH, Helsinki, Finland. marit.graner@hus.fiNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17462871

Citation

Granér, Marit, et al. "Apolipoprotein E Polymorphism Is Associated With Both Carotid and Coronary Atherosclerosis in Patients With Coronary Artery Disease." Nutrition, Metabolism, and Cardiovascular Diseases : NMCD, vol. 18, no. 4, 2008, pp. 271-7.
Granér M, Kahri J, Varpula M, et al. Apolipoprotein E polymorphism is associated with both carotid and coronary atherosclerosis in patients with coronary artery disease. Nutr Metab Cardiovasc Dis. 2008;18(4):271-7.
Granér, M., Kahri, J., Varpula, M., Salonen, R. M., Nyyssönen, K., Jauhiainen, M., Nieminen, M. S., Syvänne, M., & Taskinen, M. R. (2008). Apolipoprotein E polymorphism is associated with both carotid and coronary atherosclerosis in patients with coronary artery disease. Nutrition, Metabolism, and Cardiovascular Diseases : NMCD, 18(4), 271-7.
Granér M, et al. Apolipoprotein E Polymorphism Is Associated With Both Carotid and Coronary Atherosclerosis in Patients With Coronary Artery Disease. Nutr Metab Cardiovasc Dis. 2008;18(4):271-7. PubMed PMID: 17462871.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Apolipoprotein E polymorphism is associated with both carotid and coronary atherosclerosis in patients with coronary artery disease. AU - Granér,Marit, AU - Kahri,Juhani, AU - Varpula,Marjut, AU - Salonen,Riitta M, AU - Nyyssönen,Kristiina, AU - Jauhiainen,Matti, AU - Nieminen,Markku S, AU - Syvänne,Mikko, AU - Taskinen,Marja-Riitta, Y1 - 2007/04/26/ PY - 2006/08/10/received PY - 2006/12/01/revised PY - 2007/01/10/accepted PY - 2007/4/28/pubmed PY - 2008/7/26/medline PY - 2007/4/28/entrez SP - 271 EP - 7 JF - Nutrition, metabolism, and cardiovascular diseases : NMCD JO - Nutr Metab Cardiovasc Dis VL - 18 IS - 4 N2 - BACKGROUND AND AIMS: Apolipoprotein E (apoE) polymorphism plays a significant role in the development of atherosclerosis and cardiovascular disease. Therefore, the aim of the present study was to examine the association between apoE polymorphism and carotid intima-media thickness (IMT), and severity and extent of coronary artery disease (CAD). METHODS AND RESULTS: B-mode ultrasound and quantitative coronary angiography (QCA) were used to assess carotid, and coronary artery atherosclerosis in 91 patients with clinically suspected CAD referred for cardiac catheterization. Two apoE phenotype groups were defined: apoE3 (E3/E3) and apoE4 (including E4/E3, E4/E4 phenotypes). Maximum IMT was higher in the apoE4 group than in the apoE3 group (p=0.022). The global atheroma burden index was similarly higher in the apoE4 group than in the apoE3 group (p=0.033). ApoE4 subjects had higher levels of apolipoprotein B (apoB) (p=0.008), triglycerides (p=0.006), remnant lipoprotein-cholesterol (RLP-C) (p=0.023), and lipoprotein(a) [(Lp(a)] (p=0.041) than apoE3 subjects. The mean LDL particle size was smaller in the apoE4 group than in the apoE3 group (p=0.041). CONCLUSIONS: ApoE polymorphism was associated with both carotid and coronary atherosclerosis. Patients with the apoE4 isoform had an increased carotid IMT and a more severe and extensive CAD than patients with the apoE3 isoform. SN - 1590-3729 UR - https://www.unboundmedicine.com/medline/citation/17462871/Apolipoprotein_E_polymorphism_is_associated_with_both_carotid_and_coronary_atherosclerosis_in_patients_with_coronary_artery_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0939-4753(07)00014-2 DB - PRIME DP - Unbound Medicine ER -