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Serum leptin, oxidized low density lipoprotein and plasma asymmetric dimethylarginine levels and their relationship with dyslipidaemia in adolescent girls with polycystic ovary syndrome.
Clin Endocrinol (Oxf). 2007 Jul; 67(1):129-34.CE

Abstract

OBJECTIVE

The aim of this study was to investigate serum leptin, oxidized low density lipoprotein (ox-LDL) and asymmetric dimethylarginine (ADMA) levels and their interaction with dyslipidaemia in adolescents with polycystic ovary syndrome (PCOS).

PATIENTS AND DESIGN

The study group consisted of 23 obese (obPCOS) and 21 nonobese girls with PCOS (nPCOS), and 31 lean healthy controls. PCOS was defined by the National Institutes of Health (NIH) criteria as the presence of chronic oligoanovulation and hyperandrogenism. Fasting leptin, ox-LDL, ADMA and detailed lipid-lipoprotein profile were determined. Atherogenic index (AI) was calculated as [Total cholesterol - HDL cholesterol/HDL cholesterol]. Logarithmic transformations were made for ox-LDL.

RESULTS

Total cholesterol, triglycerides, LDL cholesterol, very low density lipoprotein (VLDL) cholesterol, apolipoprotein B, lipoprotein A levels and AI were higher and apolipoprotein AI was lower in obPCOS compared to those in controls (P < 0.05). LDL cholesterol, apolipoprotein B and lipoprotein A levels were higher in nPCOS compared to controls (P < 0.05). ADMA and ox-LDL levels did not differ in the three groups. Leptin was significantly higher in obPCOS compared with that in the other two groups (P < 0.001) and it was correlated with triglycerides (r = 0.62), VLDL cholesterol (r = 0.45), lipoprotein A (r = 0.38) and AI (r = 0.43) in the PCOS group (P < 0.05).

CONCLUSION

Our data demonstrate that ADMA and ox-LDL levels in adolescent PCOS subjects were not different than those in controls. Abnormal lipid profile was shown in obese and nonobese girls with PCOS and leptin was related with these lipid abnormalities in the PCOS subjects.

Authors+Show Affiliations

Demirel F
Department of Pediatric Endocrinology, Gazi University, Medical Faculty, Ankara, Turkey. demirelf@gmail.com
Bideci A
No affiliation info available
Cinaz P
No affiliation info available
Camurdan MO
No affiliation info available
Biberoğlu G
No affiliation info available
Yesilkaya E
No affiliation info available
Hasanoğlu A
No affiliation info available

MeSH

AdolescentApolipoproteins BArginineBiomarkersCase-Control StudiesCholesterolCholesterol, LDLDyslipidemiasFemaleHumansLeptinLipoprotein(a)Lipoproteins, LDLLipoproteins, VLDLMultivariate AnalysisObesityPolycystic Ovary SyndromeTriglycerides

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17465999

Citation

Demirel, Fatma, et al. "Serum Leptin, Oxidized Low Density Lipoprotein and Plasma Asymmetric Dimethylarginine Levels and Their Relationship With Dyslipidaemia in Adolescent Girls With Polycystic Ovary Syndrome." Clinical Endocrinology, vol. 67, no. 1, 2007, pp. 129-34.
Demirel F, Bideci A, Cinaz P, et al. Serum leptin, oxidized low density lipoprotein and plasma asymmetric dimethylarginine levels and their relationship with dyslipidaemia in adolescent girls with polycystic ovary syndrome. Clin Endocrinol (Oxf). 2007;67(1):129-34.
Demirel, F., Bideci, A., Cinaz, P., Camurdan, M. O., Biberoğlu, G., Yesilkaya, E., & Hasanoğlu, A. (2007). Serum leptin, oxidized low density lipoprotein and plasma asymmetric dimethylarginine levels and their relationship with dyslipidaemia in adolescent girls with polycystic ovary syndrome. Clinical Endocrinology, 67(1), 129-34.
Demirel F, et al. Serum Leptin, Oxidized Low Density Lipoprotein and Plasma Asymmetric Dimethylarginine Levels and Their Relationship With Dyslipidaemia in Adolescent Girls With Polycystic Ovary Syndrome. Clin Endocrinol (Oxf). 2007;67(1):129-34. PubMed PMID: 17465999.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum leptin, oxidized low density lipoprotein and plasma asymmetric dimethylarginine levels and their relationship with dyslipidaemia in adolescent girls with polycystic ovary syndrome. AU - Demirel,Fatma, AU - Bideci,Aysun, AU - Cinaz,Peyami, AU - Camurdan,M Orhun, AU - Biberoğlu,Gürsel, AU - Yesilkaya,Ediz, AU - Hasanoğlu,Alev, Y1 - 2007/04/25/ PY - 2007/5/1/pubmed PY - 2007/12/6/medline PY - 2007/5/1/entrez SP - 129 EP - 34 JF - Clinical endocrinology JO - Clin Endocrinol (Oxf) VL - 67 IS - 1 N2 - OBJECTIVE: The aim of this study was to investigate serum leptin, oxidized low density lipoprotein (ox-LDL) and asymmetric dimethylarginine (ADMA) levels and their interaction with dyslipidaemia in adolescents with polycystic ovary syndrome (PCOS). PATIENTS AND DESIGN: The study group consisted of 23 obese (obPCOS) and 21 nonobese girls with PCOS (nPCOS), and 31 lean healthy controls. PCOS was defined by the National Institutes of Health (NIH) criteria as the presence of chronic oligoanovulation and hyperandrogenism. Fasting leptin, ox-LDL, ADMA and detailed lipid-lipoprotein profile were determined. Atherogenic index (AI) was calculated as [Total cholesterol - HDL cholesterol/HDL cholesterol]. Logarithmic transformations were made for ox-LDL. RESULTS: Total cholesterol, triglycerides, LDL cholesterol, very low density lipoprotein (VLDL) cholesterol, apolipoprotein B, lipoprotein A levels and AI were higher and apolipoprotein AI was lower in obPCOS compared to those in controls (P < 0.05). LDL cholesterol, apolipoprotein B and lipoprotein A levels were higher in nPCOS compared to controls (P < 0.05). ADMA and ox-LDL levels did not differ in the three groups. Leptin was significantly higher in obPCOS compared with that in the other two groups (P < 0.001) and it was correlated with triglycerides (r = 0.62), VLDL cholesterol (r = 0.45), lipoprotein A (r = 0.38) and AI (r = 0.43) in the PCOS group (P < 0.05). CONCLUSION: Our data demonstrate that ADMA and ox-LDL levels in adolescent PCOS subjects were not different than those in controls. Abnormal lipid profile was shown in obese and nonobese girls with PCOS and leptin was related with these lipid abnormalities in the PCOS subjects. SN - 0300-0664 UR - https://www.unboundmedicine.com/medline/citation/17465999/Serum_leptin_oxidized_low_density_lipoprotein_and_plasma_asymmetric_dimethylarginine_levels_and_their_relationship_with_dyslipidaemia_in_adolescent_girls_with_polycystic_ovary_syndrome_ DB - PRIME DP - Unbound Medicine ER -