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Effect of topical honey application along with intralesional injection of glucantime in the treatment of cutaneous leishmaniasis.
BMC Complement Altern Med. 2007 Apr 27; 7:13.BC

Abstract

BACKGROUND

Leishmaniasis is an endemic disease in Iran. Although many treatments have been suggested for this disease, there hasn't been an effective and safe treatment yet. Regarding the healing effect of honey in the chronic ulcers and its reported therapeutic effect in cutaneous leishmaniasis, we performed a study to better evaluate the efficacy of honey in cutaneous leishmaniasis and its final scar.

METHODS

In a prospective clinical trial, 100 patients with confirmed cutaneous leishmaniasis were selected and randomized into 2 groups. Group A were treated with topical honey twice daily along with intralesional injection of glucantime once weekly until complete healing of the ulcer or for maximum of 6 weeks. Group B were treated with intralesional injection of glucantime alone until complete healing of the ulcer or for a maximum of 6 weeks, too. The patients were followed for 4 months. The collected data were analyzed statistically using statistical tests including Chi-square, Mann Whitney and Kaplan-Mayer tests.

RESULTS

In this study, 45 patients that had cutaneous leishmaniasis were treated with intralesional glucantime alone and 45 patients were treated with topical honey and glucantime. Ten patients left out the study. In the glucantime alone treated group, 32 patients (71.1%) had complete cure whereas in the group treated with both glucantime & topical honey, 23 patients (51.1%) achieved complete cure. This difference was significant statistically (p = 0.04).

CONCLUSION

Further studies to better clarify the efficacy of honey in cutaneous leishmaniasis is needed. We suggest that in another study, the efficacy of honey with standardized level of antibacterial activity is evaluated against cutaneous leishmaniasis.

Authors+Show Affiliations

Skin Disease and Leishmaniasis Research Center (Sedigheh Tahereh), Isfahan University of Medical Sciences, Isfahan, Iran. nilfroushzadeh@mui.ac.irNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

17466071

Citation

Nilforoushzadeh, Mohammad Ali, et al. "Effect of Topical Honey Application Along With Intralesional Injection of Glucantime in the Treatment of Cutaneous Leishmaniasis." BMC Complementary and Alternative Medicine, vol. 7, 2007, p. 13.
Nilforoushzadeh MA, Jaffary F, Moradi S, et al. Effect of topical honey application along with intralesional injection of glucantime in the treatment of cutaneous leishmaniasis. BMC Complement Altern Med. 2007;7:13.
Nilforoushzadeh, M. A., Jaffary, F., Moradi, S., Derakhshan, R., & Haftbaradaran, E. (2007). Effect of topical honey application along with intralesional injection of glucantime in the treatment of cutaneous leishmaniasis. BMC Complementary and Alternative Medicine, 7, 13.
Nilforoushzadeh MA, et al. Effect of Topical Honey Application Along With Intralesional Injection of Glucantime in the Treatment of Cutaneous Leishmaniasis. BMC Complement Altern Med. 2007 Apr 27;7:13. PubMed PMID: 17466071.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of topical honey application along with intralesional injection of glucantime in the treatment of cutaneous leishmaniasis. AU - Nilforoushzadeh,Mohammad Ali, AU - Jaffary,Fariba, AU - Moradi,Shahram, AU - Derakhshan,Roya, AU - Haftbaradaran,Elaheh, Y1 - 2007/04/27/ PY - 2006/02/02/received PY - 2007/04/27/accepted PY - 2007/5/1/pubmed PY - 2007/8/4/medline PY - 2007/5/1/entrez SP - 13 EP - 13 JF - BMC complementary and alternative medicine JO - BMC Complement Altern Med VL - 7 N2 - BACKGROUND: Leishmaniasis is an endemic disease in Iran. Although many treatments have been suggested for this disease, there hasn't been an effective and safe treatment yet. Regarding the healing effect of honey in the chronic ulcers and its reported therapeutic effect in cutaneous leishmaniasis, we performed a study to better evaluate the efficacy of honey in cutaneous leishmaniasis and its final scar. METHODS: In a prospective clinical trial, 100 patients with confirmed cutaneous leishmaniasis were selected and randomized into 2 groups. Group A were treated with topical honey twice daily along with intralesional injection of glucantime once weekly until complete healing of the ulcer or for maximum of 6 weeks. Group B were treated with intralesional injection of glucantime alone until complete healing of the ulcer or for a maximum of 6 weeks, too. The patients were followed for 4 months. The collected data were analyzed statistically using statistical tests including Chi-square, Mann Whitney and Kaplan-Mayer tests. RESULTS: In this study, 45 patients that had cutaneous leishmaniasis were treated with intralesional glucantime alone and 45 patients were treated with topical honey and glucantime. Ten patients left out the study. In the glucantime alone treated group, 32 patients (71.1%) had complete cure whereas in the group treated with both glucantime & topical honey, 23 patients (51.1%) achieved complete cure. This difference was significant statistically (p = 0.04). CONCLUSION: Further studies to better clarify the efficacy of honey in cutaneous leishmaniasis is needed. We suggest that in another study, the efficacy of honey with standardized level of antibacterial activity is evaluated against cutaneous leishmaniasis. SN - 1472-6882 UR - https://www.unboundmedicine.com/medline/citation/17466071/Effect_of_topical_honey_application_along_with_intralesional_injection_of_glucantime_in_the_treatment_of_cutaneous_leishmaniasis_ L2 - https://bmccomplementalternmed.biomedcentral.com/articles/10.1186/1472-6882-7-13 DB - PRIME DP - Unbound Medicine ER -