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The intake of flavonoids and carotid atherosclerosis: the Kuopio Ischaemic Heart Disease Risk Factor Study.
Br J Nutr. 2007 Oct; 98(4):814-8.BJ

Abstract

The role of flavonoids in CVD is still unclear. In this cross-sectional study we assessed the relation between the intakes of twenty-six flavonoids from five subclasses: flavonols, flavones, flavanones, flavan-3-ols and anthocyanidins, and the mean common carotid artery intima-media thickness (CCA-IMT). The study population consisted of 1380 middle-aged eastern Finnish men for whom the mean CCA-IMT examinations were carried out as a part of the prospective population-based Kuopio Ischaemic Heart Disease Risk Factor Study (KIHD). The mean intake of flavonoids was 128.5 (sd 206.7) mg/d and the mean CCA-IMT was 0.78 (sd 0.17) mm. In the lowest quartile of total flavonoid intake the non-adjusted mean CCA-IMT was 0.79 (sd 0.19) mm, while the mean CCA-IMT was 0.76 (sd 0.15) in the highest quartile (P < 0.001). After adjustment for age, variables related to CCA-IMT measurement, history of atherosclerosis, smoking, BMI, diabetes, systolic blood pressure, serum HDL- and LDL-cholesterol, VO2 max, and intakes of alcohol, SFA, folate, vitamins C and E, the total flavonoid intake was inversely associated with the mean CCA-IMT (P = 0.018). Out of different flavonoid subclasses, flavan-3-ols were inversely associated with CCA-IMT (P = 0.025) after statistical adjustment. There was a trend for an inverse association between intake of flavonols and mean CCA-IMT (P = 0.055). We conclude that high intake of flavonoids is associated with decreased carotid atherosclerosis in middle-aged Finnish men.

Authors+Show Affiliations

The Research Institute of Public Health, University of Kuopio, Kuopio, Finland. jaakko.mursu@uku.fiNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17466095

Citation

Mursu, Jaakko, et al. "The Intake of Flavonoids and Carotid Atherosclerosis: the Kuopio Ischaemic Heart Disease Risk Factor Study." The British Journal of Nutrition, vol. 98, no. 4, 2007, pp. 814-8.
Mursu J, Nurmi T, Tuomainen TP, et al. The intake of flavonoids and carotid atherosclerosis: the Kuopio Ischaemic Heart Disease Risk Factor Study. Br J Nutr. 2007;98(4):814-8.
Mursu, J., Nurmi, T., Tuomainen, T. P., Ruusunen, A., Salonen, J. T., & Voutilainen, S. (2007). The intake of flavonoids and carotid atherosclerosis: the Kuopio Ischaemic Heart Disease Risk Factor Study. The British Journal of Nutrition, 98(4), 814-8.
Mursu J, et al. The Intake of Flavonoids and Carotid Atherosclerosis: the Kuopio Ischaemic Heart Disease Risk Factor Study. Br J Nutr. 2007;98(4):814-8. PubMed PMID: 17466095.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The intake of flavonoids and carotid atherosclerosis: the Kuopio Ischaemic Heart Disease Risk Factor Study. AU - Mursu,Jaakko, AU - Nurmi,Tarja, AU - Tuomainen,Tomi-Pekka, AU - Ruusunen,Anu, AU - Salonen,Jukka T, AU - Voutilainen,Sari, Y1 - 2007/04/30/ PY - 2007/5/1/pubmed PY - 2008/2/12/medline PY - 2007/5/1/entrez SP - 814 EP - 8 JF - The British journal of nutrition JO - Br. J. Nutr. VL - 98 IS - 4 N2 - The role of flavonoids in CVD is still unclear. In this cross-sectional study we assessed the relation between the intakes of twenty-six flavonoids from five subclasses: flavonols, flavones, flavanones, flavan-3-ols and anthocyanidins, and the mean common carotid artery intima-media thickness (CCA-IMT). The study population consisted of 1380 middle-aged eastern Finnish men for whom the mean CCA-IMT examinations were carried out as a part of the prospective population-based Kuopio Ischaemic Heart Disease Risk Factor Study (KIHD). The mean intake of flavonoids was 128.5 (sd 206.7) mg/d and the mean CCA-IMT was 0.78 (sd 0.17) mm. In the lowest quartile of total flavonoid intake the non-adjusted mean CCA-IMT was 0.79 (sd 0.19) mm, while the mean CCA-IMT was 0.76 (sd 0.15) in the highest quartile (P < 0.001). After adjustment for age, variables related to CCA-IMT measurement, history of atherosclerosis, smoking, BMI, diabetes, systolic blood pressure, serum HDL- and LDL-cholesterol, VO2 max, and intakes of alcohol, SFA, folate, vitamins C and E, the total flavonoid intake was inversely associated with the mean CCA-IMT (P = 0.018). Out of different flavonoid subclasses, flavan-3-ols were inversely associated with CCA-IMT (P = 0.025) after statistical adjustment. There was a trend for an inverse association between intake of flavonols and mean CCA-IMT (P = 0.055). We conclude that high intake of flavonoids is associated with decreased carotid atherosclerosis in middle-aged Finnish men. SN - 0007-1145 UR - https://www.unboundmedicine.com/medline/citation/17466095/The_intake_of_flavonoids_and_carotid_atherosclerosis:_the_Kuopio_Ischaemic_Heart_Disease_Risk_Factor_Study_ L2 - https://www.cambridge.org/core/product/identifier/S0007114507744410/type/journal_article DB - PRIME DP - Unbound Medicine ER -