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Distributions of C-reactive protein and its association with metabolic syndrome in middle-aged and older Chinese people.
J Am Coll Cardiol 2007; 49(17):1798-805JACC

Abstract

OBJECTIVES

We evaluated the distributions of C-reactive protein (CRP) and its association with metabolic syndrome (MetS) in middle-aged and older Chinese people.

BACKGROUND

Several studies have suggested that CRP is a risk factor of MetS. However, it remains unclear how CRP levels are distributed and whether they are associated with MetS in Chinese people.

METHODS

We conducted a population-based cross-sectional survey in 2005 in Beijing and Shanghai, with a total of 1,458 men and 1,831 women age 50 to 70 years. Metabolic syndrome was defined according to the updated National Cholesterol Education Program Adult Treatment Panel III criteria for Asian Americans.

RESULTS

The median CRP level was 0.68 mg/l among the study population. The CRP levels were significantly higher among participants from Beijing or from urban areas than those in participants from Shanghai or from rural areas (p < 0.01). No gender difference in CRP levels was observed. The prevalence of MetS progressively increased with elevated CRP levels (p < 0.0001 for trend). In the highest quartile of CRP levels (>1.50 mg/l), the risk for MetS was substantially higher (odds ratio 5.97; 95% confidence interval 4.75 to 7.51) compared with that in the lowest quartile of CRP levels (< or =0.33 mg/l) after adjustment for age, gender, geographic location, lifestyle factors, educational attainment, and family history of chronic diseases. This association was observed in both obese and nonobese participants.

CONCLUSIONS

The overall plasma level of CRP is low but highly associated with the MetS among the middle-aged and elderly Chinese population. Prospective studies are needed to investigate the role of CRP in the development of MetS and related chronic diseases among Chinese people.

Authors+Show Affiliations

Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Graduate School of the Chinese Academy of Sciences, Shanghai, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17466231

Citation

Ye, Xingwang, et al. "Distributions of C-reactive Protein and Its Association With Metabolic Syndrome in Middle-aged and Older Chinese People." Journal of the American College of Cardiology, vol. 49, no. 17, 2007, pp. 1798-805.
Ye X, Yu Z, Li H, et al. Distributions of C-reactive protein and its association with metabolic syndrome in middle-aged and older Chinese people. J Am Coll Cardiol. 2007;49(17):1798-805.
Ye, X., Yu, Z., Li, H., Franco, O. H., Liu, Y., & Lin, X. (2007). Distributions of C-reactive protein and its association with metabolic syndrome in middle-aged and older Chinese people. Journal of the American College of Cardiology, 49(17), pp. 1798-805.
Ye X, et al. Distributions of C-reactive Protein and Its Association With Metabolic Syndrome in Middle-aged and Older Chinese People. J Am Coll Cardiol. 2007 May 1;49(17):1798-805. PubMed PMID: 17466231.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Distributions of C-reactive protein and its association with metabolic syndrome in middle-aged and older Chinese people. AU - Ye,Xingwang, AU - Yu,Zhijie, AU - Li,Huaixing, AU - Franco,Oscar H, AU - Liu,Yong, AU - Lin,Xu, Y1 - 2007/04/16/ PY - 2006/09/25/received PY - 2007/01/05/revised PY - 2007/01/15/accepted PY - 2007/5/1/pubmed PY - 2007/5/16/medline PY - 2007/5/1/entrez SP - 1798 EP - 805 JF - Journal of the American College of Cardiology JO - J. Am. Coll. Cardiol. VL - 49 IS - 17 N2 - OBJECTIVES: We evaluated the distributions of C-reactive protein (CRP) and its association with metabolic syndrome (MetS) in middle-aged and older Chinese people. BACKGROUND: Several studies have suggested that CRP is a risk factor of MetS. However, it remains unclear how CRP levels are distributed and whether they are associated with MetS in Chinese people. METHODS: We conducted a population-based cross-sectional survey in 2005 in Beijing and Shanghai, with a total of 1,458 men and 1,831 women age 50 to 70 years. Metabolic syndrome was defined according to the updated National Cholesterol Education Program Adult Treatment Panel III criteria for Asian Americans. RESULTS: The median CRP level was 0.68 mg/l among the study population. The CRP levels were significantly higher among participants from Beijing or from urban areas than those in participants from Shanghai or from rural areas (p < 0.01). No gender difference in CRP levels was observed. The prevalence of MetS progressively increased with elevated CRP levels (p < 0.0001 for trend). In the highest quartile of CRP levels (>1.50 mg/l), the risk for MetS was substantially higher (odds ratio 5.97; 95% confidence interval 4.75 to 7.51) compared with that in the lowest quartile of CRP levels (< or =0.33 mg/l) after adjustment for age, gender, geographic location, lifestyle factors, educational attainment, and family history of chronic diseases. This association was observed in both obese and nonobese participants. CONCLUSIONS: The overall plasma level of CRP is low but highly associated with the MetS among the middle-aged and elderly Chinese population. Prospective studies are needed to investigate the role of CRP in the development of MetS and related chronic diseases among Chinese people. SN - 1558-3597 UR - https://www.unboundmedicine.com/medline/citation/17466231/Distributions_of_C_reactive_protein_and_its_association_with_metabolic_syndrome_in_middle_aged_and_older_Chinese_people_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0735-1097(07)00637-7 DB - PRIME DP - Unbound Medicine ER -