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Prevalence of the metabolic syndrome in individuals with hyperuricemia.
Am J Med. 2007 May; 120(5):442-7.AJ

Abstract

PURPOSE

The link between hyperuricemia and insulin resistance has been noted, but the prevalence of the metabolic syndrome by recent definitions among individuals with hyperuricemia remains unclear. Our objective was to determine the prevalence of the metabolic syndrome according to serum uric acid levels in a nationally representative sample of US adults.

METHODS

By using data from 8669 participants aged 20 years and more in The Third National Health and Nutrition Examination Survey (1988-1994), we determined the prevalence of the metabolic syndrome at different serum uric acid levels. We used both the revised and original National Cholesterol Education Program Adult Treatment Panel (NCEP/ATP) III criteria to define the metabolic syndrome.

RESULTS

The prevalences of the metabolic syndrome according to the revised NCEP/ATP III criteria were 18.9% (95% confidence interval [CI], 16.8-21.0) for uric acid levels less than 6 mg/dL, 36.0% (95% CI, 32.5-39.6) for uric acid levels from 6 to 6.9 mg/dL, 40.8% (95% CI, 35.3-46.4) for uric acid levels from 7 to 7.9 mg/dL, 59.7% (95% CI, 53.0-66.4) for uric acid levels from 8 to 8.9 mg/dL, 62.0% (95% CI, 53.0-66.4) for uric acid levels from 9 to 9.9 mg/dL, and 70.7% for uric acid levels of 10 mg/dL or greater. The increasing trends persisted in subgroups stratified by sex, age group, alcohol intake, body mass index, hypertension, and diabetes. For example, among individuals with normal body mass index (<25 kg/m2), the prevalence increased from 5.9% (95% CI, 4.8-7.0), for a uric acid level of less than 6 mg/dL, to 59.0%, (95% CI, 20.1-97.9) for a uric acid level of 10 mg/dL or greater. With the original NCEP/ATP criteria, the corresponding prevalences were slightly lower.

CONCLUSIONS

These findings from a nationally representative sample of US adults indicate that the prevalence of the metabolic syndrome increases substantially with increasing levels of serum uric acid. Physicians should recognize the metabolic syndrome as a frequent comorbidity of hyperuricemia and treat it to prevent serious complications.

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Authors+Show Affiliations

Choi HK
Rheumatology Division, Arthritis Research Centre of Canada, Department of Medicine, Vancouver General Hospital, University of British Columbia, Vancouver, Canada. hchoi@partners.org
Ford ES
No affiliation info available

MeSH

AdultBody Mass IndexFemaleHumansHyperuricemiaMaleMetabolic SyndromeMiddle AgedMultivariate AnalysisNutrition SurveysPrevalenceUnited StatesUric Acid

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17466656

Citation

Choi, Hyon K., and Earl S. Ford. "Prevalence of the Metabolic Syndrome in Individuals With Hyperuricemia." The American Journal of Medicine, vol. 120, no. 5, 2007, pp. 442-7.
Choi HK, Ford ES. Prevalence of the metabolic syndrome in individuals with hyperuricemia. Am J Med. 2007;120(5):442-7.
Choi, H. K., & Ford, E. S. (2007). Prevalence of the metabolic syndrome in individuals with hyperuricemia. The American Journal of Medicine, 120(5), 442-7.
Choi HK, Ford ES. Prevalence of the Metabolic Syndrome in Individuals With Hyperuricemia. Am J Med. 2007;120(5):442-7. PubMed PMID: 17466656.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevalence of the metabolic syndrome in individuals with hyperuricemia. AU - Choi,Hyon K, AU - Ford,Earl S, PY - 2006/05/25/received PY - 2006/06/07/revised PY - 2006/06/14/accepted PY - 2007/5/1/pubmed PY - 2007/5/23/medline PY - 2007/5/1/entrez SP - 442 EP - 7 JF - The American journal of medicine JO - Am J Med VL - 120 IS - 5 N2 - PURPOSE: The link between hyperuricemia and insulin resistance has been noted, but the prevalence of the metabolic syndrome by recent definitions among individuals with hyperuricemia remains unclear. Our objective was to determine the prevalence of the metabolic syndrome according to serum uric acid levels in a nationally representative sample of US adults. METHODS: By using data from 8669 participants aged 20 years and more in The Third National Health and Nutrition Examination Survey (1988-1994), we determined the prevalence of the metabolic syndrome at different serum uric acid levels. We used both the revised and original National Cholesterol Education Program Adult Treatment Panel (NCEP/ATP) III criteria to define the metabolic syndrome. RESULTS: The prevalences of the metabolic syndrome according to the revised NCEP/ATP III criteria were 18.9% (95% confidence interval [CI], 16.8-21.0) for uric acid levels less than 6 mg/dL, 36.0% (95% CI, 32.5-39.6) for uric acid levels from 6 to 6.9 mg/dL, 40.8% (95% CI, 35.3-46.4) for uric acid levels from 7 to 7.9 mg/dL, 59.7% (95% CI, 53.0-66.4) for uric acid levels from 8 to 8.9 mg/dL, 62.0% (95% CI, 53.0-66.4) for uric acid levels from 9 to 9.9 mg/dL, and 70.7% for uric acid levels of 10 mg/dL or greater. The increasing trends persisted in subgroups stratified by sex, age group, alcohol intake, body mass index, hypertension, and diabetes. For example, among individuals with normal body mass index (<25 kg/m2), the prevalence increased from 5.9% (95% CI, 4.8-7.0), for a uric acid level of less than 6 mg/dL, to 59.0%, (95% CI, 20.1-97.9) for a uric acid level of 10 mg/dL or greater. With the original NCEP/ATP criteria, the corresponding prevalences were slightly lower. CONCLUSIONS: These findings from a nationally representative sample of US adults indicate that the prevalence of the metabolic syndrome increases substantially with increasing levels of serum uric acid. Physicians should recognize the metabolic syndrome as a frequent comorbidity of hyperuricemia and treat it to prevent serious complications. SN - 1555-7162 UR - https://www.unboundmedicine.com/medline/citation/17466656/Prevalence_of_the_metabolic_syndrome_in_individuals_with_hyperuricemia_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002-9343(06)00890-4 DB - PRIME DP - Unbound Medicine ER -