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The anxiolytic effect of cinnabar involves changes of serotonin levels.
Eur J Pharmacol. 2007 Jun 22; 565(1-3):132-7.EJ

Abstract

The aim of this study was to explore the neuropharmacological mechanism of cinnabar. The anxiolytic effect of cinnabar on anxiety-like behaviors in mice was investigated using the elevated plus maze test. The changes in the levels of monoamine neurotransmitters and their metabolites and the activity of monoamine oxidase (MAO) in the brain of mice were determined. The results indicate that cinnabar possessed anxiolytic effects after chronic administration (p.o.) at effective doses in association with the declined brain serotonin (5-HT) level. The cinnabar showed no effects on 5-HT metabolism pathway. The results suggested the potential importance of the brain serotonergic system. The 5-HT metabolism pathway may be not involved in the anxiolytic effects of cinnabar.

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Authors+Show Affiliations

Wang Q
School of Public Health, Peking University, Beijing 100083, P.R. China.
Yang X
No affiliation info available
Zhang B
No affiliation info available
Yang X
No affiliation info available
Wang K
No affiliation info available

MeSH

AnimalsAnti-Anxiety AgentsBrain ChemistryDose-Response Relationship, DrugMaleMaze LearningMercury CompoundsMiceMice, Inbred C57BLSerotonin

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17466969

Citation

Wang, Qi, et al. "The Anxiolytic Effect of Cinnabar Involves Changes of Serotonin Levels." European Journal of Pharmacology, vol. 565, no. 1-3, 2007, pp. 132-7.
Wang Q, Yang X, Zhang B, et al. The anxiolytic effect of cinnabar involves changes of serotonin levels. Eur J Pharmacol. 2007;565(1-3):132-7.
Wang, Q., Yang, X., Zhang, B., Yang, X., & Wang, K. (2007). The anxiolytic effect of cinnabar involves changes of serotonin levels. European Journal of Pharmacology, 565(1-3), 132-7.
Wang Q, et al. The Anxiolytic Effect of Cinnabar Involves Changes of Serotonin Levels. Eur J Pharmacol. 2007 Jun 22;565(1-3):132-7. PubMed PMID: 17466969.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The anxiolytic effect of cinnabar involves changes of serotonin levels. AU - Wang,Qi, AU - Yang,Xiaoda, AU - Zhang,Baoxu, AU - Yang,Xiuwei, AU - Wang,Kui, Y1 - 2007/03/24/ PY - 2006/10/16/received PY - 2007/03/01/revised PY - 2007/03/06/accepted PY - 2007/5/1/pubmed PY - 2007/7/27/medline PY - 2007/5/1/entrez SP - 132 EP - 7 JF - European journal of pharmacology JO - Eur J Pharmacol VL - 565 IS - 1-3 N2 - The aim of this study was to explore the neuropharmacological mechanism of cinnabar. The anxiolytic effect of cinnabar on anxiety-like behaviors in mice was investigated using the elevated plus maze test. The changes in the levels of monoamine neurotransmitters and their metabolites and the activity of monoamine oxidase (MAO) in the brain of mice were determined. The results indicate that cinnabar possessed anxiolytic effects after chronic administration (p.o.) at effective doses in association with the declined brain serotonin (5-HT) level. The cinnabar showed no effects on 5-HT metabolism pathway. The results suggested the potential importance of the brain serotonergic system. The 5-HT metabolism pathway may be not involved in the anxiolytic effects of cinnabar. SN - 0014-2999 UR - https://www.unboundmedicine.com/medline/citation/17466969/The_anxiolytic_effect_of_cinnabar_involves_changes_of_serotonin_levels_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0014-2999(07)00355-X DB - PRIME DP - Unbound Medicine ER -