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Human papillomavirus infection and oral cancer: a case-control study in Montreal, Canada.
Oral Oncol. 2008 Mar; 44(3):242-50.OO

Abstract

The objective of the present study was to examine the association between human papillomavirus (HPV) infection and risk of developing oral cancer. The investigation followed a hospital-based case-control design. Cases consisted of newly diagnosed patients with squamous cell carcinoma of the oral cavity and oropharynx. Controls were frequency matched to cases on gender, age, and hospital. Subjects were interviewed to elicit information on putative risk factors. Oral exfoliated cells were tested for detection of HPV DNA by the PGMY09/11 polymerase chain reaction protocol. Serum antibodies against HPV 16, 18, and 31 viral capsids were detected using an immunoassay technique. Logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CI) of oral cancer according to HPV exposure variables. HPV DNA was detected in 19% of cases (14 out of 72), and 5% of controls (six out of 129). Among tonsil-related cancers (palatine tonsil and base of tongue) viral DNA was detected in 43% of cases (nine out of 21). The OR for tonsil-related cancers for high-risk HPV types was 19.32 (95%CI: 2.3-159.5), after adjustment for socio-demographic characteristics, tobacco, and alcohol consumption. The equivalent OR for HPV 16 seropositivity was 31.51 (95%CI: 4.5-219.7). The ORs of non-tonsillar oral cancers for high risk HPV DNA in oral cells and for seropositivity were 2.14 (95%CI: 0.4-13.0) and 3.16 (95%CI: 0.8-13.0), respectively. These results provide evidence supporting a strong causal association between HPV infection and tonsil-related cancers. The evidence for an etiologic link is less clear for non-tonsillar oral cancers.

Authors+Show Affiliations

Division of Cancer Epidemiology, McGill University, Montreal, Canada.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17467327

Citation

Pintos, Javier, et al. "Human Papillomavirus Infection and Oral Cancer: a Case-control Study in Montreal, Canada." Oral Oncology, vol. 44, no. 3, 2008, pp. 242-50.
Pintos J, Black MJ, Sadeghi N, et al. Human papillomavirus infection and oral cancer: a case-control study in Montreal, Canada. Oral Oncol. 2008;44(3):242-50.
Pintos, J., Black, M. J., Sadeghi, N., Ghadirian, P., Zeitouni, A. G., Viscidi, R. P., Herrero, R., Coutlée, F., & Franco, E. L. (2008). Human papillomavirus infection and oral cancer: a case-control study in Montreal, Canada. Oral Oncology, 44(3), 242-50.
Pintos J, et al. Human Papillomavirus Infection and Oral Cancer: a Case-control Study in Montreal, Canada. Oral Oncol. 2008;44(3):242-50. PubMed PMID: 17467327.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Human papillomavirus infection and oral cancer: a case-control study in Montreal, Canada. AU - Pintos,Javier, AU - Black,Martin J, AU - Sadeghi,Nader, AU - Ghadirian,Parviz, AU - Zeitouni,Anthony G, AU - Viscidi,Raphael P, AU - Herrero,Rolando, AU - Coutlée,François, AU - Franco,Eduardo L, Y1 - 2007/04/27/ PY - 2006/11/17/received PY - 2007/02/21/accepted PY - 2007/5/1/pubmed PY - 2008/8/30/medline PY - 2007/5/1/entrez SP - 242 EP - 50 JF - Oral oncology JO - Oral Oncol. VL - 44 IS - 3 N2 - The objective of the present study was to examine the association between human papillomavirus (HPV) infection and risk of developing oral cancer. The investigation followed a hospital-based case-control design. Cases consisted of newly diagnosed patients with squamous cell carcinoma of the oral cavity and oropharynx. Controls were frequency matched to cases on gender, age, and hospital. Subjects were interviewed to elicit information on putative risk factors. Oral exfoliated cells were tested for detection of HPV DNA by the PGMY09/11 polymerase chain reaction protocol. Serum antibodies against HPV 16, 18, and 31 viral capsids were detected using an immunoassay technique. Logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CI) of oral cancer according to HPV exposure variables. HPV DNA was detected in 19% of cases (14 out of 72), and 5% of controls (six out of 129). Among tonsil-related cancers (palatine tonsil and base of tongue) viral DNA was detected in 43% of cases (nine out of 21). The OR for tonsil-related cancers for high-risk HPV types was 19.32 (95%CI: 2.3-159.5), after adjustment for socio-demographic characteristics, tobacco, and alcohol consumption. The equivalent OR for HPV 16 seropositivity was 31.51 (95%CI: 4.5-219.7). The ORs of non-tonsillar oral cancers for high risk HPV DNA in oral cells and for seropositivity were 2.14 (95%CI: 0.4-13.0) and 3.16 (95%CI: 0.8-13.0), respectively. These results provide evidence supporting a strong causal association between HPV infection and tonsil-related cancers. The evidence for an etiologic link is less clear for non-tonsillar oral cancers. SN - 1368-8375 UR - https://www.unboundmedicine.com/medline/citation/17467327/Human_papillomavirus_infection_and_oral_cancer:_a_case_control_study_in_Montreal_Canada_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1368-8375(07)00067-X DB - PRIME DP - Unbound Medicine ER -