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Simultaneous voltammetric detection of dopamine and uric acid at their physiological level in the presence of ascorbic acid using poly(acrylic acid)-multiwalled carbon-nanotube composite-covered glassy-carbon electrode.
Biosens Bioelectron. 2007 Aug 30; 23(1):74-80.BB

Abstract

The use of poly(acrylic acid) (PAA)-multiwalled carbon-nanotubes (MWNTs) composite-coated glassy-carbon disk electrode (GCE) (PAA-MWNTs/GCE) for the simultaneous determination of physiological level dopamine (DA) and uric acid (UA) in the presence of an excess of ascorbic acid (AA) in a pH 7.4 phosphate-buffered solution was proposed. PAA-MWNTs composite was prepared by mixing of MWNTs powder into 1 mg/ml PAA aqueous solution under sonication. GCE surface was modified with PAA-MWNTs film by casting. AA demonstrates no voltammetric peak at PAA-MWNTs/GCE. The PAA-MWNTs composite is of a high surface area and of affinity for DA and UA adsorption. DA exhibits greatly improved electron-transfer rate and is electro-catalyzed at PAA-MWNTs/GCE. Moreover, the electro-catalytic oxidation of UA at PAA-MWNTs/GCE is observed, which makes it possible to detect lower level UA. Therefore, the enhanced electrocatalytic currents for DA and UA were observed. The anodic peak currents at approximately 0.18 V and 0.35 V increase with the increasing concentrations of DA and UA, respectively, which correspond to the voltammetric peaks of DA and UA, respectively. The linear ranges are 40 nM to 3 microM DA and 0.3 microM to 10 microM UA in the presence of 0.3 mM AA. The lowest detection limits (S/N=3) were 20 nM DA and 110 nM UA.

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Authors+Show Affiliations

Liu A
Nano-Energy Materials Group, Energy Technology Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Umezono 1-1-1, Tsukuba 305-8568, Japan. liuaihua@hotmail.com
Honma I
No affiliation info available
Zhou H
No affiliation info available

MeSH

Acrylic ResinsAscorbic AcidBiosensing TechniquesBody FluidsCoated Materials, BiocompatibleComplex MixturesDopamineElectrochemistryEquipment DesignEquipment Failure AnalysisNanotubes, CarbonReproducibility of ResultsSensitivity and SpecificityUric Acid

Pub Type(s)

Evaluation Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17467972

Citation

Liu, Aihua, et al. "Simultaneous Voltammetric Detection of Dopamine and Uric Acid at Their Physiological Level in the Presence of Ascorbic Acid Using Poly(acrylic Acid)-multiwalled Carbon-nanotube Composite-covered Glassy-carbon Electrode." Biosensors & Bioelectronics, vol. 23, no. 1, 2007, pp. 74-80.
Liu A, Honma I, Zhou H. Simultaneous voltammetric detection of dopamine and uric acid at their physiological level in the presence of ascorbic acid using poly(acrylic acid)-multiwalled carbon-nanotube composite-covered glassy-carbon electrode. Biosens Bioelectron. 2007;23(1):74-80.
Liu, A., Honma, I., & Zhou, H. (2007). Simultaneous voltammetric detection of dopamine and uric acid at their physiological level in the presence of ascorbic acid using poly(acrylic acid)-multiwalled carbon-nanotube composite-covered glassy-carbon electrode. Biosensors & Bioelectronics, 23(1), 74-80.
Liu A, Honma I, Zhou H. Simultaneous Voltammetric Detection of Dopamine and Uric Acid at Their Physiological Level in the Presence of Ascorbic Acid Using Poly(acrylic Acid)-multiwalled Carbon-nanotube Composite-covered Glassy-carbon Electrode. Biosens Bioelectron. 2007 Aug 30;23(1):74-80. PubMed PMID: 17467972.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Simultaneous voltammetric detection of dopamine and uric acid at their physiological level in the presence of ascorbic acid using poly(acrylic acid)-multiwalled carbon-nanotube composite-covered glassy-carbon electrode. AU - Liu,Aihua, AU - Honma,Itaru, AU - Zhou,Haoshen, Y1 - 2007/03/30/ PY - 2006/12/10/received PY - 2007/02/03/revised PY - 2007/03/19/accepted PY - 2007/5/1/pubmed PY - 2007/12/6/medline PY - 2007/5/1/entrez SP - 74 EP - 80 JF - Biosensors & bioelectronics JO - Biosens Bioelectron VL - 23 IS - 1 N2 - The use of poly(acrylic acid) (PAA)-multiwalled carbon-nanotubes (MWNTs) composite-coated glassy-carbon disk electrode (GCE) (PAA-MWNTs/GCE) for the simultaneous determination of physiological level dopamine (DA) and uric acid (UA) in the presence of an excess of ascorbic acid (AA) in a pH 7.4 phosphate-buffered solution was proposed. PAA-MWNTs composite was prepared by mixing of MWNTs powder into 1 mg/ml PAA aqueous solution under sonication. GCE surface was modified with PAA-MWNTs film by casting. AA demonstrates no voltammetric peak at PAA-MWNTs/GCE. The PAA-MWNTs composite is of a high surface area and of affinity for DA and UA adsorption. DA exhibits greatly improved electron-transfer rate and is electro-catalyzed at PAA-MWNTs/GCE. Moreover, the electro-catalytic oxidation of UA at PAA-MWNTs/GCE is observed, which makes it possible to detect lower level UA. Therefore, the enhanced electrocatalytic currents for DA and UA were observed. The anodic peak currents at approximately 0.18 V and 0.35 V increase with the increasing concentrations of DA and UA, respectively, which correspond to the voltammetric peaks of DA and UA, respectively. The linear ranges are 40 nM to 3 microM DA and 0.3 microM to 10 microM UA in the presence of 0.3 mM AA. The lowest detection limits (S/N=3) were 20 nM DA and 110 nM UA. SN - 0956-5663 UR - https://www.unboundmedicine.com/medline/citation/17467972/Simultaneous_voltammetric_detection_of_dopamine_and_uric_acid_at_their_physiological_level_in_the_presence_of_ascorbic_acid_using_poly_acrylic_acid__multiwalled_carbon_nanotube_composite_covered_glassy_carbon_electrode_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0956-5663(07)00182-0 DB - PRIME DP - Unbound Medicine ER -
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