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HER2 expression and efficacy of preoperative paclitaxel/FAC chemotherapy in breast cancer.
Breast Cancer Res Treat. 2008 Mar; 108(2):183-90.BC

Abstract

PURPOSE

We examined the correlation between HER2 expression and pathologic complete response (pCR) to paclitaxel/FAC (T/FAC) preoperative chemotherapy in breast cancer.

PATIENTS AND METHODS

Retrospective analysis of data including 534 patients treated with preoperative T/FAC was performed. Gene expression results were available from two datasets of 132 and 286 patients, and were used to examine the co-expression of HER2 and topoisomerase II alpha (TOP2A) and microtubule associated protein tau (MAP-Tau).

RESULTS

Of the 534 patients, 105 (20%) had HER2-overexpressing breast cancer. The pCR rates were 33% and 15% for patients with HER2+ and HER2- tumors (P<0.001). The 5-year relapse-free survival rates were 94% and 70% in HER2+ tumors with and without pCR (P=0.009). HER2 overexpression (odds ratio 2.3, 95%CI: 1.3-3.9, P=0.004), estrogen receptor (ER) status, grade and weekly schedule of paclitaxel were each significantly and independently associated with pCR in multivariate analysis. When patients were stratified by ER status, the pCR rates were 50% for HER2+/ER-, 30% for HER2-/ER-, 19% for HER2+/ER+, and 6% for HER2-/ER+ tumors. HER2 overexpression was associated with lower expression of MAP-tau (P=0.001 and P<0.001) and higher expression of TOP2A mRNAs (P=0.048 and P=0.001) in patients with ER+ disease. ER- cancers had low MAP-tau expression regardless of HER-status.

CONCLUSION

HER2 overexpression is associated with higher rate of pCR to preoperative T/FAC chemotherapy regardless of ER status. HER2 overexpression also correlates with increased TOP2A and decreased MAP-tau expression in ER-positive cancers.

Authors+Show Affiliations

Breast Cancer Unit, Institut Gustave Roussy, Villejuif, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17468948

Citation

Andre, Fabrice, et al. "HER2 Expression and Efficacy of Preoperative paclitaxel/FAC Chemotherapy in Breast Cancer." Breast Cancer Research and Treatment, vol. 108, no. 2, 2008, pp. 183-90.
Andre F, Mazouni C, Liedtke C, et al. HER2 expression and efficacy of preoperative paclitaxel/FAC chemotherapy in breast cancer. Breast Cancer Res Treat. 2008;108(2):183-90.
Andre, F., Mazouni, C., Liedtke, C., Kau, S. W., Frye, D., Green, M., Gonzalez-Angulo, A. M., Symmans, W. F., Hortobagyi, G. N., & Pusztai, L. (2008). HER2 expression and efficacy of preoperative paclitaxel/FAC chemotherapy in breast cancer. Breast Cancer Research and Treatment, 108(2), 183-90.
Andre F, et al. HER2 Expression and Efficacy of Preoperative paclitaxel/FAC Chemotherapy in Breast Cancer. Breast Cancer Res Treat. 2008;108(2):183-90. PubMed PMID: 17468948.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - HER2 expression and efficacy of preoperative paclitaxel/FAC chemotherapy in breast cancer. AU - Andre,Fabrice, AU - Mazouni,Chafika, AU - Liedtke,Cornelia, AU - Kau,Shu-Wan, AU - Frye,Debby, AU - Green,Marjorie, AU - Gonzalez-Angulo,Ana M, AU - Symmans,W Fraser, AU - Hortobagyi,Gabriel N, AU - Pusztai,Lajos, Y1 - 2007/04/28/ PY - 2007/01/23/received PY - 2007/04/03/accepted PY - 2007/5/1/pubmed PY - 2008/5/23/medline PY - 2007/5/1/entrez SP - 183 EP - 90 JF - Breast cancer research and treatment JO - Breast Cancer Res Treat VL - 108 IS - 2 N2 - PURPOSE: We examined the correlation between HER2 expression and pathologic complete response (pCR) to paclitaxel/FAC (T/FAC) preoperative chemotherapy in breast cancer. PATIENTS AND METHODS: Retrospective analysis of data including 534 patients treated with preoperative T/FAC was performed. Gene expression results were available from two datasets of 132 and 286 patients, and were used to examine the co-expression of HER2 and topoisomerase II alpha (TOP2A) and microtubule associated protein tau (MAP-Tau). RESULTS: Of the 534 patients, 105 (20%) had HER2-overexpressing breast cancer. The pCR rates were 33% and 15% for patients with HER2+ and HER2- tumors (P<0.001). The 5-year relapse-free survival rates were 94% and 70% in HER2+ tumors with and without pCR (P=0.009). HER2 overexpression (odds ratio 2.3, 95%CI: 1.3-3.9, P=0.004), estrogen receptor (ER) status, grade and weekly schedule of paclitaxel were each significantly and independently associated with pCR in multivariate analysis. When patients were stratified by ER status, the pCR rates were 50% for HER2+/ER-, 30% for HER2-/ER-, 19% for HER2+/ER+, and 6% for HER2-/ER+ tumors. HER2 overexpression was associated with lower expression of MAP-tau (P=0.001 and P<0.001) and higher expression of TOP2A mRNAs (P=0.048 and P=0.001) in patients with ER+ disease. ER- cancers had low MAP-tau expression regardless of HER-status. CONCLUSION: HER2 overexpression is associated with higher rate of pCR to preoperative T/FAC chemotherapy regardless of ER status. HER2 overexpression also correlates with increased TOP2A and decreased MAP-tau expression in ER-positive cancers. SN - 0167-6806 UR - https://www.unboundmedicine.com/medline/citation/17468948/HER2_expression_and_efficacy_of_preoperative_paclitaxel/FAC_chemotherapy_in_breast_cancer_ L2 - https://doi.org/10.1007/s10549-007-9594-8 DB - PRIME DP - Unbound Medicine ER -