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Papaya seed represents a rich source of biologically active isothiocyanate.
J Agric Food Chem. 2007 May 30; 55(11):4407-13.JA

Abstract

In the present study, papaya (Carica papaya) seed and edible pulp were carefully separated and then the contents of benzyl isothiocyanate and the corresponding glucosinolate (benzyl glucosinolate, glucotropaeolin) quantified in each part. The papaya seed with myrosinase inactivation contained >1 mmol of benzyl glucosinolate in 100 g of fresh seed. This content is equivalent to that of Karami daikon (the hottest Japanese white radish) or that of cress. The papaya seed extract also showed a very high activity of myrosinase and, without myrosinase inactivation, produced 460 micromol of benzyl isothiocyanate in 100 g of seed. In contrast, papaya pulp contained an undetectable amount of benzyl glucosinolate and showed no significant myrosinase activity. The n-hexane extract of the papaya seed homogenate was highly effective in inhibiting superoxide generation and apoptosis induction in HL-60 cells, the activities of which are comparable to those of authentic benzyl isothiocyanate.

Authors+Show Affiliations

Department of Biofunctional Chemistry, Division of Bioscience, Graduate School of Natural Science and Technology, Okayama University, Okayama 700-8530, Japan. yossan@cc.oakayama-u.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17469845

Citation

Nakamura, Yoshimasa, et al. "Papaya Seed Represents a Rich Source of Biologically Active Isothiocyanate." Journal of Agricultural and Food Chemistry, vol. 55, no. 11, 2007, pp. 4407-13.
Nakamura Y, Yoshimoto M, Murata Y, et al. Papaya seed represents a rich source of biologically active isothiocyanate. J Agric Food Chem. 2007;55(11):4407-13.
Nakamura, Y., Yoshimoto, M., Murata, Y., Shimoishi, Y., Asai, Y., Park, E. Y., Sato, K., & Nakamura, Y. (2007). Papaya seed represents a rich source of biologically active isothiocyanate. Journal of Agricultural and Food Chemistry, 55(11), 4407-13.
Nakamura Y, et al. Papaya Seed Represents a Rich Source of Biologically Active Isothiocyanate. J Agric Food Chem. 2007 May 30;55(11):4407-13. PubMed PMID: 17469845.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Papaya seed represents a rich source of biologically active isothiocyanate. AU - Nakamura,Yoshimasa, AU - Yoshimoto,Motoko, AU - Murata,Yoshiyuki, AU - Shimoishi,Yasuaki, AU - Asai,Yumi, AU - Park,Eun Young, AU - Sato,Kenji, AU - Nakamura,Yasushi, Y1 - 2007/05/01/ PY - 2007/5/2/pubmed PY - 2007/9/7/medline PY - 2007/5/2/entrez SP - 4407 EP - 13 JF - Journal of agricultural and food chemistry JO - J Agric Food Chem VL - 55 IS - 11 N2 - In the present study, papaya (Carica papaya) seed and edible pulp were carefully separated and then the contents of benzyl isothiocyanate and the corresponding glucosinolate (benzyl glucosinolate, glucotropaeolin) quantified in each part. The papaya seed with myrosinase inactivation contained >1 mmol of benzyl glucosinolate in 100 g of fresh seed. This content is equivalent to that of Karami daikon (the hottest Japanese white radish) or that of cress. The papaya seed extract also showed a very high activity of myrosinase and, without myrosinase inactivation, produced 460 micromol of benzyl isothiocyanate in 100 g of seed. In contrast, papaya pulp contained an undetectable amount of benzyl glucosinolate and showed no significant myrosinase activity. The n-hexane extract of the papaya seed homogenate was highly effective in inhibiting superoxide generation and apoptosis induction in HL-60 cells, the activities of which are comparable to those of authentic benzyl isothiocyanate. SN - 0021-8561 UR - https://www.unboundmedicine.com/medline/citation/17469845/Papaya_seed_represents_a_rich_source_of_biologically_active_isothiocyanate_ L2 - https://doi.org/10.1021/jf070159w DB - PRIME DP - Unbound Medicine ER -