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Behavioral and subjective effects of d-amphetamine and modafinil in healthy adults.
Exp Clin Psychopharmacol. 2007 Apr; 15(2):123-33.EC

Abstract

Modafinil is indicated for the management of excessive daytime sleepiness; however, recent studies have examined a broad range of potential uses. Given that clinical uses of modafinil may be expanding, this study compared modafinil and d-amphetamine effects on subjective and performance measures. Across 11 sessions, 11 healthy adults were tested after oral doses of placebo (5 sessions), modafinil (1.75 mg/kg, 3.50 mg/kg, or 7.00 mg/kg), and d-amphetamine (0.035 mg/kg, 0.070 mg/kg, 0.140 mg/kg) under double-blind, randomized conditions. Assessments of cognitive performance and subjective effects were completed before drug administration, 30 min after drug administration, and at hourly intervals after drug administration for 5 hr. Modafinil increased ratings on the Amphetamine and Morphine Benzedrine Group scales of the Addiction Research Center Inventory (ARCI) and increased ratings on the Vigor and Total Positive scales of the Profile of Mood States. d-Amphetamine increased visual analog ratings of feeling stimulated and liking the drug and increased ratings on the Morphine Benzedrine Group scale of the ARCI. Both medications significantly reduced visual analog scale ratings of feeling sleepy, and modafinil decreased ratings on the ARCI Pentobarbital-Chlorpromazine-Alcohol Group scale. Both medications sustained performance that deteriorated across time on the Sternberg Number Recognition Test. Modafinil also enhanced performance rate on the Digit-Symbol Substitution Task above baseline levels and increased response rate on the Repeated Acquisition of Response Sequences Task. These results suggest that modafinil engenders alerting effects and increases performance in healthy non-sleep-deprived individuals comparable with that of d-amphetamine.

Authors+Show Affiliations

Center for Obesity Research and Education, Temple University, Philadelphia, PA 19140, USA. makrisa@temple.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

17469936

Citation

Makris, Angela P., et al. "Behavioral and Subjective Effects of D-amphetamine and Modafinil in Healthy Adults." Experimental and Clinical Psychopharmacology, vol. 15, no. 2, 2007, pp. 123-33.
Makris AP, Rush CR, Frederich RC, et al. Behavioral and subjective effects of d-amphetamine and modafinil in healthy adults. Exp Clin Psychopharmacol. 2007;15(2):123-33.
Makris, A. P., Rush, C. R., Frederich, R. C., Taylor, A. C., & Kelly, T. H. (2007). Behavioral and subjective effects of d-amphetamine and modafinil in healthy adults. Experimental and Clinical Psychopharmacology, 15(2), 123-33.
Makris AP, et al. Behavioral and Subjective Effects of D-amphetamine and Modafinil in Healthy Adults. Exp Clin Psychopharmacol. 2007;15(2):123-33. PubMed PMID: 17469936.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Behavioral and subjective effects of d-amphetamine and modafinil in healthy adults. AU - Makris,Angela P, AU - Rush,Craig R, AU - Frederich,Robert C, AU - Taylor,Alisia C, AU - Kelly,Thomas H, PY - 2007/5/2/pubmed PY - 2007/6/27/medline PY - 2007/5/2/entrez SP - 123 EP - 33 JF - Experimental and clinical psychopharmacology JO - Exp Clin Psychopharmacol VL - 15 IS - 2 N2 - Modafinil is indicated for the management of excessive daytime sleepiness; however, recent studies have examined a broad range of potential uses. Given that clinical uses of modafinil may be expanding, this study compared modafinil and d-amphetamine effects on subjective and performance measures. Across 11 sessions, 11 healthy adults were tested after oral doses of placebo (5 sessions), modafinil (1.75 mg/kg, 3.50 mg/kg, or 7.00 mg/kg), and d-amphetamine (0.035 mg/kg, 0.070 mg/kg, 0.140 mg/kg) under double-blind, randomized conditions. Assessments of cognitive performance and subjective effects were completed before drug administration, 30 min after drug administration, and at hourly intervals after drug administration for 5 hr. Modafinil increased ratings on the Amphetamine and Morphine Benzedrine Group scales of the Addiction Research Center Inventory (ARCI) and increased ratings on the Vigor and Total Positive scales of the Profile of Mood States. d-Amphetamine increased visual analog ratings of feeling stimulated and liking the drug and increased ratings on the Morphine Benzedrine Group scale of the ARCI. Both medications significantly reduced visual analog scale ratings of feeling sleepy, and modafinil decreased ratings on the ARCI Pentobarbital-Chlorpromazine-Alcohol Group scale. Both medications sustained performance that deteriorated across time on the Sternberg Number Recognition Test. Modafinil also enhanced performance rate on the Digit-Symbol Substitution Task above baseline levels and increased response rate on the Repeated Acquisition of Response Sequences Task. These results suggest that modafinil engenders alerting effects and increases performance in healthy non-sleep-deprived individuals comparable with that of d-amphetamine. SN - 1064-1297 UR - https://www.unboundmedicine.com/medline/citation/17469936/Behavioral_and_subjective_effects_of_d_amphetamine_and_modafinil_in_healthy_adults_ L2 - http://content.apa.org/journals/pha/15/2/123 DB - PRIME DP - Unbound Medicine ER -