Tags

Type your tag names separated by a space and hit enter

ETB receptor polymorphism is associated with airway obstruction.
BMC Pulm Med. 2007 Apr 30; 7:5.BP

Abstract

BACKGROUND

Endothelin-1 (EDN1) has been involved in the development of airway obstruction and inflammation in asthma. Several polymorphisms have been identified among the genes encoding for preproET1, an inactive precursor of ET-1, and for ETA (EDNRA) and ETB (EDNRB), the two receptors for EDN1. In the present work, we hypothesised that molecular variation in these genes could be a major determinant of the degree of bronchial obstruction. The purpose of this study was to investigate whether the genetic polymorphisms of preproET-1, EDNRA and EDNRB genes were associated with the degree of airway obstruction, assessed by FEV1.

METHODS

Polymorphisms of preproET-1, EDNRA and EDNRB were first studied in a population of adult asthmatic patients. Results were confirmed in a large population of adults from the general population from the ECRHS II study.

RESULTS

In our population of adult asthmatic patients, the EDNRB-30G>A (Leu277Leu) polymorphism (GG genotype) is strongly associated with a low FEV1 and with a higher percentage of patients with FEV1 < 80% of predicted value. No relationship was found between pulmonary function and EDNRA-1363C>T (His323His) or preproET-1-595G>T (Lys198Asp) polymorphism. In the adult population from the ECRHS II, we found a similar association between GG genotype and a low FEV1 or a higher percentage of subjects with FEV1 < 80% predicted, especially in the subgroups of asthmatics subjects (OR = 4.31 (95%CI 1.03 - 18.04)) and smokers (OR = 7.42 (95%CI 1.69 - 32.6)).

CONCLUSION

the EDNRB-30G>A polymorphism could be a determinant of airway obstruction in humans with predisposing factors such as tobacco smoke exposure or asthma.

Authors+Show Affiliations

Service de Pneumologie, Hôpital Bichat-Claude Bernard, Assistance Publique-Hôpitaux de Paris, Paris, France. camille.taille@bch.aphp.frNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17470272

Citation

Taillé, Camille, et al. "ETB Receptor Polymorphism Is Associated With Airway Obstruction." BMC Pulmonary Medicine, vol. 7, 2007, p. 5.
Taillé C, Guénégou A, Almolki A, et al. ETB receptor polymorphism is associated with airway obstruction. BMC Pulm Med. 2007;7:5.
Taillé, C., Guénégou, A., Almolki, A., Piperaud, M., Leynaert, B., Vuillaumier, S., Neukirch, F., Boczkowski, J., Aubier, M., Benessiano, J., & Crestani, B. (2007). ETB receptor polymorphism is associated with airway obstruction. BMC Pulmonary Medicine, 7, 5.
Taillé C, et al. ETB Receptor Polymorphism Is Associated With Airway Obstruction. BMC Pulm Med. 2007 Apr 30;7:5. PubMed PMID: 17470272.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - ETB receptor polymorphism is associated with airway obstruction. AU - Taillé,Camille, AU - Guénégou,Armelle, AU - Almolki,Abdelhamid, AU - Piperaud,Marie, AU - Leynaert,Bénédicte, AU - Vuillaumier,Sandrine, AU - Neukirch,Françoise, AU - Boczkowski,Jorge, AU - Aubier,Michel, AU - Benessiano,Joëlle, AU - Crestani,Bruno, Y1 - 2007/04/30/ PY - 2006/07/11/received PY - 2007/04/30/accepted PY - 2007/5/2/pubmed PY - 2007/7/3/medline PY - 2007/5/2/entrez SP - 5 EP - 5 JF - BMC pulmonary medicine JO - BMC Pulm Med VL - 7 N2 - BACKGROUND: Endothelin-1 (EDN1) has been involved in the development of airway obstruction and inflammation in asthma. Several polymorphisms have been identified among the genes encoding for preproET1, an inactive precursor of ET-1, and for ETA (EDNRA) and ETB (EDNRB), the two receptors for EDN1. In the present work, we hypothesised that molecular variation in these genes could be a major determinant of the degree of bronchial obstruction. The purpose of this study was to investigate whether the genetic polymorphisms of preproET-1, EDNRA and EDNRB genes were associated with the degree of airway obstruction, assessed by FEV1. METHODS: Polymorphisms of preproET-1, EDNRA and EDNRB were first studied in a population of adult asthmatic patients. Results were confirmed in a large population of adults from the general population from the ECRHS II study. RESULTS: In our population of adult asthmatic patients, the EDNRB-30G>A (Leu277Leu) polymorphism (GG genotype) is strongly associated with a low FEV1 and with a higher percentage of patients with FEV1 < 80% of predicted value. No relationship was found between pulmonary function and EDNRA-1363C>T (His323His) or preproET-1-595G>T (Lys198Asp) polymorphism. In the adult population from the ECRHS II, we found a similar association between GG genotype and a low FEV1 or a higher percentage of subjects with FEV1 < 80% predicted, especially in the subgroups of asthmatics subjects (OR = 4.31 (95%CI 1.03 - 18.04)) and smokers (OR = 7.42 (95%CI 1.69 - 32.6)). CONCLUSION: the EDNRB-30G>A polymorphism could be a determinant of airway obstruction in humans with predisposing factors such as tobacco smoke exposure or asthma. SN - 1471-2466 UR - https://www.unboundmedicine.com/medline/citation/17470272/ETB_receptor_polymorphism_is_associated_with_airway_obstruction_ L2 - https://bmcpulmmed.biomedcentral.com/articles/10.1186/1471-2466-7-5 DB - PRIME DP - Unbound Medicine ER -