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Depressive symptoms in subjects with diagnosed and undiagnosed type 2 diabetes.
Psychosom Med 2007; 69(4):300-5PM

Abstract

OBJECTIVE

To investigate if disturbed glucose homeostasis or known diagnosis of diabetes was associated with depressive symptoms. The reason for the increased prevalence of depression in patients with Type 2 diabetes mellitus (DM2) is unknown.

METHODS

Within the Utrecht Health Project, an ongoing longitudinal study among inhabitants of a residential area of a large city in The Netherlands, 4747 subjects (age: 39.4 +/- 12.5 years) were classified into four mutually exclusive categories: normal fasting plasma glucose (FPG) (<5.6 mmol/l), impaired FPG (> or =5.6 and <7.0 mmol/l), undiagnosed DM2 (FPG > or =7.0 mmol/l), and diagnosed DM2. Presence of depressive symptoms was defined as a score of > or =25 on the depression subscale of the Symptom Check List (SCL-90) or self-reported use of antidepressants.

RESULTS

Diagnosed DM2 was associated with an increased risk of depressive symptoms (odds ratio (OR) = 1.69; 95% confidence interval (CI) 1.06-2.72) after adjustment for demographic and lifestyle variables. Additional adjustment for number of chronic diseases reduced the OR to 1.36 (95% CI 0.83-2.23). Impaired fasting glucose and undiagnosed DM2 were not associated with depressive symptoms.

CONCLUSIONS

Our findings suggest that disturbed glucose homeostasis is not associated with depressive symptoms. The increased prevalence of depressive symptoms among patients with diagnosed DM2 suggests that depressive symptoms might be a consequence of the burden of diabetes. The number of chronic diseases seems to explain part of the association between DM2 and depressive symptoms.

Authors+Show Affiliations

Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands. m.j.knol@umcutrecht.nlNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17470664

Citation

Knol, Mirjam J., et al. "Depressive Symptoms in Subjects With Diagnosed and Undiagnosed Type 2 Diabetes." Psychosomatic Medicine, vol. 69, no. 4, 2007, pp. 300-5.
Knol MJ, Heerdink ER, Egberts AC, et al. Depressive symptoms in subjects with diagnosed and undiagnosed type 2 diabetes. Psychosom Med. 2007;69(4):300-5.
Knol, M. J., Heerdink, E. R., Egberts, A. C., Geerlings, M. I., Gorter, K. J., Numans, M. E., ... Burger, H. (2007). Depressive symptoms in subjects with diagnosed and undiagnosed type 2 diabetes. Psychosomatic Medicine, 69(4), pp. 300-5.
Knol MJ, et al. Depressive Symptoms in Subjects With Diagnosed and Undiagnosed Type 2 Diabetes. Psychosom Med. 2007;69(4):300-5. PubMed PMID: 17470664.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Depressive symptoms in subjects with diagnosed and undiagnosed type 2 diabetes. AU - Knol,Mirjam J, AU - Heerdink,Eibert R, AU - Egberts,Antoine C G, AU - Geerlings,Mirjam I, AU - Gorter,Kees J, AU - Numans,Mattijs E, AU - Grobbee,Diederick E, AU - Klungel,Olaf H, AU - Burger,Huibert, Y1 - 2007/04/30/ PY - 2007/5/2/pubmed PY - 2007/7/10/medline PY - 2007/5/2/entrez SP - 300 EP - 5 JF - Psychosomatic medicine JO - Psychosom Med VL - 69 IS - 4 N2 - OBJECTIVE: To investigate if disturbed glucose homeostasis or known diagnosis of diabetes was associated with depressive symptoms. The reason for the increased prevalence of depression in patients with Type 2 diabetes mellitus (DM2) is unknown. METHODS: Within the Utrecht Health Project, an ongoing longitudinal study among inhabitants of a residential area of a large city in The Netherlands, 4747 subjects (age: 39.4 +/- 12.5 years) were classified into four mutually exclusive categories: normal fasting plasma glucose (FPG) (<5.6 mmol/l), impaired FPG (> or =5.6 and <7.0 mmol/l), undiagnosed DM2 (FPG > or =7.0 mmol/l), and diagnosed DM2. Presence of depressive symptoms was defined as a score of > or =25 on the depression subscale of the Symptom Check List (SCL-90) or self-reported use of antidepressants. RESULTS: Diagnosed DM2 was associated with an increased risk of depressive symptoms (odds ratio (OR) = 1.69; 95% confidence interval (CI) 1.06-2.72) after adjustment for demographic and lifestyle variables. Additional adjustment for number of chronic diseases reduced the OR to 1.36 (95% CI 0.83-2.23). Impaired fasting glucose and undiagnosed DM2 were not associated with depressive symptoms. CONCLUSIONS: Our findings suggest that disturbed glucose homeostasis is not associated with depressive symptoms. The increased prevalence of depressive symptoms among patients with diagnosed DM2 suggests that depressive symptoms might be a consequence of the burden of diabetes. The number of chronic diseases seems to explain part of the association between DM2 and depressive symptoms. SN - 1534-7796 UR - https://www.unboundmedicine.com/medline/citation/17470664/Depressive_symptoms_in_subjects_with_diagnosed_and_undiagnosed_type_2_diabetes_ L2 - http://Insights.ovid.com/pubmed?pmid=17470664 DB - PRIME DP - Unbound Medicine ER -