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Serum concentrations of uric acid and the metabolic syndrome among US children and adolescents.
Circulation. 2007 May 15; 115(19):2526-32.Circ

Abstract

BACKGROUND

The association between concentrations of uric acid and the metabolic syndrome in children and adolescents remains incompletely understood. The objective of this study was to examine how these 2 were associated in a nationally representative sample of US children and adolescents.

METHODS AND RESULTS

We performed a cross-sectional analysis of 1370 males and females aged 12 to 17 years using data from the National Health and Nutrition Examination Survey 1999-2002. The prevalence of the metabolic syndrome was < 1% among participants in the lowest quartile of serum concentration of uric acid, 3.7% in the second quartile, 10.3% in the third quartile, and 21.1% in the highest quartile. Compared with the lowest 2 quartiles of uric acid together (< or = 291.5 micromol/L), the odds ratios were 5.80 (95% confidence interval, 3.22 to 10.46) for those in the third quartile (> 291.5 to < or = 339 micromol/L or > 4.9 to < or = 5.7 mg/dL) and 14.79 (95% confidence interval, 7.78 to 28.11) for those in the top quartile (> 339 micromol/L) after adjustment for age, sex, race or ethnicity, and concentrations of C-reactive protein. Starting with the lowest quartile of concentration of uric acid, mean concentrations of serum insulin were 66.2, 66.7, 79.9, and 90.9 pmol/L for ascending quartiles, respectively (P for trend <0.001).

CONCLUSIONS

Among US children and adolescents, serum concentrations of uric acid are strongly associated with the prevalence of the metabolic syndrome and several of its components.

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Authors+Show Affiliations

Ford ES
Division of Adult and Community Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, 4770 Buford Hwy, MS K66, Atlanta, GA 30341, USA. eford@cdc.gov
Li C
No affiliation info available
Cook S
No affiliation info available
Choi HK
No affiliation info available

MeSH

AdolescentAnthropometryArea Under CurveBiomarkersBlood GlucoseBlood PressureC-Reactive ProteinChildCholesterol, HDLCross-Sectional StudiesEthnic GroupsFemaleHumansInsulinKidneyMaleMetabolic SyndromePredictive Value of TestsPrevalenceROC CurveRiskTriglyceridesUnited StatesUric Acid

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

17470699

Clinical Trial Links

Paediatric Obesity and Cardiovascular Dysfunction

Citation

Ford, Earl S., et al. "Serum Concentrations of Uric Acid and the Metabolic Syndrome Among US Children and Adolescents." Circulation, vol. 115, no. 19, 2007, pp. 2526-32.
Ford ES, Li C, Cook S, et al. Serum concentrations of uric acid and the metabolic syndrome among US children and adolescents. Circulation. 2007;115(19):2526-32.
Ford, E. S., Li, C., Cook, S., & Choi, H. K. (2007). Serum concentrations of uric acid and the metabolic syndrome among US children and adolescents. Circulation, 115(19), 2526-32.
Ford ES, et al. Serum Concentrations of Uric Acid and the Metabolic Syndrome Among US Children and Adolescents. Circulation. 2007 May 15;115(19):2526-32. PubMed PMID: 17470699.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum concentrations of uric acid and the metabolic syndrome among US children and adolescents. AU - Ford,Earl S, AU - Li,Chaoyang, AU - Cook,Stephen, AU - Choi,Hyon K, Y1 - 2007/04/30/ PY - 2007/5/2/pubmed PY - 2007/6/8/medline PY - 2007/5/2/entrez SP - 2526 EP - 32 JF - Circulation JO - Circulation VL - 115 IS - 19 N2 - BACKGROUND: The association between concentrations of uric acid and the metabolic syndrome in children and adolescents remains incompletely understood. The objective of this study was to examine how these 2 were associated in a nationally representative sample of US children and adolescents. METHODS AND RESULTS: We performed a cross-sectional analysis of 1370 males and females aged 12 to 17 years using data from the National Health and Nutrition Examination Survey 1999-2002. The prevalence of the metabolic syndrome was < 1% among participants in the lowest quartile of serum concentration of uric acid, 3.7% in the second quartile, 10.3% in the third quartile, and 21.1% in the highest quartile. Compared with the lowest 2 quartiles of uric acid together (< or = 291.5 micromol/L), the odds ratios were 5.80 (95% confidence interval, 3.22 to 10.46) for those in the third quartile (> 291.5 to < or = 339 micromol/L or > 4.9 to < or = 5.7 mg/dL) and 14.79 (95% confidence interval, 7.78 to 28.11) for those in the top quartile (> 339 micromol/L) after adjustment for age, sex, race or ethnicity, and concentrations of C-reactive protein. Starting with the lowest quartile of concentration of uric acid, mean concentrations of serum insulin were 66.2, 66.7, 79.9, and 90.9 pmol/L for ascending quartiles, respectively (P for trend <0.001). CONCLUSIONS: Among US children and adolescents, serum concentrations of uric acid are strongly associated with the prevalence of the metabolic syndrome and several of its components. SN - 1524-4539 UR - https://www.unboundmedicine.com/medline/citation/17470699/Serum_concentrations_of_uric_acid_and_the_metabolic_syndrome_among_US_children_and_adolescents_ L2 - https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.106.657627?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -