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Haloperidol is as effective as ondansetron for preventing postoperative nausea and vomiting.
Can J Anaesth. 2007 May; 54(5):349-54.CJ

Abstract

PURPOSE

Recent warnings regarding the safety of droperidol have limited use of this drug as an antiemetic. Haloperidol, a butyrophenone derivative similar to droperidol, has not been rigorously evaluated as an antiemetic. The aim of this study was to compare the prophylactic antiemetic efficacy of haloperidol vs ondansetron for the prevention of postoperative nausea and vomiting (PONV) after general anesthesia.

METHODS

Ninety non-smoking female patients were eligible to participate in this randomized double-blinded study. Approximately 30 min before the end of surgery, patients were randomly assigned to receive either haloperidol 2 mg iv, or ondansetron 4 mg iv, respectively. The incidence of PONV, average pain and sedation scores, recovery times, and changes of the rate-corrected QT (QTc) interval were observed postoperatively.

RESULTS

The proportion of patients who experienced PONV in the first 24 hr was similar in the two groups (28% and 26% for haloperidol and ondansetron groups, respectively). The incidence of PONV was significantly less in both groups than predicted according to the patients' underlying risks (53% for the haloperidol group, P=0.016; 51% for the ondansetron group, P=0.015). Pain scores, sedation scores, and recovery times were similar in the two groups, and no prolongation of the QTc interval was observed in either group.

CONCLUSIONS

Haloperidol 2 mg iv given 30 min before the end of surgery is effective in preventing PONV, with efficacy comparable to ondansetron 4 mg iv for the first 24 hr after general anesthesia.

Authors+Show Affiliations

Department of Anesthesiology, Buddhist Tzu-Chi Medical Center, Tzu-Chi University School of Medicine, Hualien, Taiwan, ROC.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

17470885

Citation

Lee, Yi, et al. "Haloperidol Is as Effective as Ondansetron for Preventing Postoperative Nausea and Vomiting." Canadian Journal of Anaesthesia = Journal Canadien D'anesthesie, vol. 54, no. 5, 2007, pp. 349-54.
Lee Y, Wang PK, Lai HY, et al. Haloperidol is as effective as ondansetron for preventing postoperative nausea and vomiting. Can J Anaesth. 2007;54(5):349-54.
Lee, Y., Wang, P. K., Lai, H. Y., Yang, Y. L., Chu, C. C., & Wang, J. J. (2007). Haloperidol is as effective as ondansetron for preventing postoperative nausea and vomiting. Canadian Journal of Anaesthesia = Journal Canadien D'anesthesie, 54(5), 349-54.
Lee Y, et al. Haloperidol Is as Effective as Ondansetron for Preventing Postoperative Nausea and Vomiting. Can J Anaesth. 2007;54(5):349-54. PubMed PMID: 17470885.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Haloperidol is as effective as ondansetron for preventing postoperative nausea and vomiting. AU - Lee,Yi, AU - Wang,Po K, AU - Lai,Hsien Y, AU - Yang,Yao L, AU - Chu,Chin C, AU - Wang,Jhi J, PY - 2007/5/2/pubmed PY - 2007/12/6/medline PY - 2007/5/2/entrez SP - 349 EP - 54 JF - Canadian journal of anaesthesia = Journal canadien d'anesthesie JO - Can J Anaesth VL - 54 IS - 5 N2 - PURPOSE: Recent warnings regarding the safety of droperidol have limited use of this drug as an antiemetic. Haloperidol, a butyrophenone derivative similar to droperidol, has not been rigorously evaluated as an antiemetic. The aim of this study was to compare the prophylactic antiemetic efficacy of haloperidol vs ondansetron for the prevention of postoperative nausea and vomiting (PONV) after general anesthesia. METHODS: Ninety non-smoking female patients were eligible to participate in this randomized double-blinded study. Approximately 30 min before the end of surgery, patients were randomly assigned to receive either haloperidol 2 mg iv, or ondansetron 4 mg iv, respectively. The incidence of PONV, average pain and sedation scores, recovery times, and changes of the rate-corrected QT (QTc) interval were observed postoperatively. RESULTS: The proportion of patients who experienced PONV in the first 24 hr was similar in the two groups (28% and 26% for haloperidol and ondansetron groups, respectively). The incidence of PONV was significantly less in both groups than predicted according to the patients' underlying risks (53% for the haloperidol group, P=0.016; 51% for the ondansetron group, P=0.015). Pain scores, sedation scores, and recovery times were similar in the two groups, and no prolongation of the QTc interval was observed in either group. CONCLUSIONS: Haloperidol 2 mg iv given 30 min before the end of surgery is effective in preventing PONV, with efficacy comparable to ondansetron 4 mg iv for the first 24 hr after general anesthesia. SN - 0832-610X UR - https://www.unboundmedicine.com/medline/citation/17470885/Haloperidol_is_as_effective_as_ondansetron_for_preventing_postoperative_nausea_and_vomiting_ L2 - https://doi.org/10.1007/BF03022656 DB - PRIME DP - Unbound Medicine ER -