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Long-term memory of cocaine-associated context: disruption and reinstatement.
Neuroreport. 2007 May 28; 18(8):777-80.N

Abstract

Long-term memory of cocaine-associated context was established by conditioned place preference learning. After 1 week, exposure to context in the absence of cocaine (memory retrieval) was paired with one of the following treatments: saline, scopolamine (muscarinic acetylcholine receptor antagonist), dizocilpine (MK-801; noncompetitive N-methyl-D-aspartate antagonist) or D-cycloserine (partial N-methyl-D-aspartate agonist). In subsequent conditioned place preference tests, place preference was suppressed in the drug-treated groups but not saline-treated groups. Results suggest that the amnesic agents, scopolamine and MK-801, disrupted reconsolidation of cocaine-associated contextual memory. In contrast, the mnemonic agent D-cycloserine might have facilitated extinction learning during context exposure in the absence of cocaine. Challenge administration of cocaine reinstated place preference in all groups except the MK-801 group, suggesting that suppression of conditioned response may or may not suppress memory evoked by drug-context reexposure.

Authors+Show Affiliations

Neuroscience Program, University of Miami Miller School of Medicine, Miami, Florida 33136, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

17471065

Citation

Kelley, Jonathan B., et al. "Long-term Memory of Cocaine-associated Context: Disruption and Reinstatement." Neuroreport, vol. 18, no. 8, 2007, pp. 777-80.
Kelley JB, Anderson KL, Itzhak Y. Long-term memory of cocaine-associated context: disruption and reinstatement. Neuroreport. 2007;18(8):777-80.
Kelley, J. B., Anderson, K. L., & Itzhak, Y. (2007). Long-term memory of cocaine-associated context: disruption and reinstatement. Neuroreport, 18(8), 777-80.
Kelley JB, Anderson KL, Itzhak Y. Long-term Memory of Cocaine-associated Context: Disruption and Reinstatement. Neuroreport. 2007 May 28;18(8):777-80. PubMed PMID: 17471065.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Long-term memory of cocaine-associated context: disruption and reinstatement. AU - Kelley,Jonathan B, AU - Anderson,Karen L, AU - Itzhak,Yossef, PY - 2007/5/2/pubmed PY - 2007/7/25/medline PY - 2007/5/2/entrez SP - 777 EP - 80 JF - Neuroreport JO - Neuroreport VL - 18 IS - 8 N2 - Long-term memory of cocaine-associated context was established by conditioned place preference learning. After 1 week, exposure to context in the absence of cocaine (memory retrieval) was paired with one of the following treatments: saline, scopolamine (muscarinic acetylcholine receptor antagonist), dizocilpine (MK-801; noncompetitive N-methyl-D-aspartate antagonist) or D-cycloserine (partial N-methyl-D-aspartate agonist). In subsequent conditioned place preference tests, place preference was suppressed in the drug-treated groups but not saline-treated groups. Results suggest that the amnesic agents, scopolamine and MK-801, disrupted reconsolidation of cocaine-associated contextual memory. In contrast, the mnemonic agent D-cycloserine might have facilitated extinction learning during context exposure in the absence of cocaine. Challenge administration of cocaine reinstated place preference in all groups except the MK-801 group, suggesting that suppression of conditioned response may or may not suppress memory evoked by drug-context reexposure. SN - 0959-4965 UR - https://www.unboundmedicine.com/medline/citation/17471065/Long_term_memory_of_cocaine_associated_context:_disruption_and_reinstatement_ L2 - https://doi.org/10.1097/WNR.0b013e3280c1e2e7 DB - PRIME DP - Unbound Medicine ER -