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High risk of human papillomavirus type 16 infections and of development of cervical squamous intraepithelial lesions in systemic lupus erythematosus patients.
Arthritis Rheum 2007; 57(4):619-25AR

Abstract

OBJECTIVE

To determine rates of human papillomavirus (HPV) infections, abnormal cervical smears, and squamous intraepithelial lesions (SIL) among women with systemic lupus erythematosus (SLE).

METHODS

We investigated 30 women with SLE, 67 with abnormal smears from colposcopy clinics, and 15 community subjects with normal smears. Polymerase chain reaction results for viral DNA and HPV-16 sequencing data were correlated to cytology and colposcopic findings.

RESULTS

SLE and colposcopy patients were more likely (P < 0.05) to be HPV positive (15 [54%] and 37 [67%] patients, respectively) and HPV-16 DNA positive (16 [57%] and 17 [31%] patients, respectively) than community subjects (0% HPV DNA positive and 1 [6%] HPV-16 DNA positive). SLE patients were also more likely to be HPV-16 DNA positive than colposcopy patients (P < 0.05). SLE patients with a high HPV-16 viral load more frequently had SIL (n = 6) than those with a low HPV-16 viral load (n = 1; P < 0.05). HPV and HPV-16 DNA positivity were not associated with previous or current drug therapy for SLE patients. All HPV-16 DNA sequences from 6 SLE and 5 colposcopy patients were the European-type variant. Eighteen (60%) SLE patients had a previous or current cervical abnormality. At the time of study, 5 (17%) SLE patients had an abnormal cervical smear and 8 (27%) had SIL. For those diagnosed with SLE for >10 years, the rate of SIL was 44% lower than those with SLE for <5 years (odds ratio 0.56, 95% confidence interval 0.1-3.5).

CONCLUSION

UK women with a recent SLE diagnosis had disturbingly elevated levels of HPV infections (particularly with European HPV-16 variants at a high viral load), abnormal cervical cytology, and SIL.

Authors+Show Affiliations

St Thomas' Hospital, London, UK.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17471531

Citation

Nath, Rahul, et al. "High Risk of Human Papillomavirus Type 16 Infections and of Development of Cervical Squamous Intraepithelial Lesions in Systemic Lupus Erythematosus Patients." Arthritis and Rheumatism, vol. 57, no. 4, 2007, pp. 619-25.
Nath R, Mant C, Luxton J, et al. High risk of human papillomavirus type 16 infections and of development of cervical squamous intraepithelial lesions in systemic lupus erythematosus patients. Arthritis Rheum. 2007;57(4):619-25.
Nath, R., Mant, C., Luxton, J., Hughes, G., Raju, K. S., Shepherd, P., & Cason, J. (2007). High risk of human papillomavirus type 16 infections and of development of cervical squamous intraepithelial lesions in systemic lupus erythematosus patients. Arthritis and Rheumatism, 57(4), pp. 619-25.
Nath R, et al. High Risk of Human Papillomavirus Type 16 Infections and of Development of Cervical Squamous Intraepithelial Lesions in Systemic Lupus Erythematosus Patients. Arthritis Rheum. 2007 May 15;57(4):619-25. PubMed PMID: 17471531.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - High risk of human papillomavirus type 16 infections and of development of cervical squamous intraepithelial lesions in systemic lupus erythematosus patients. AU - Nath,Rahul, AU - Mant,Christine, AU - Luxton,Jennifer, AU - Hughes,Graham, AU - Raju,K Shanti, AU - Shepherd,Phillip, AU - Cason,John, PY - 2007/5/2/pubmed PY - 2007/6/20/medline PY - 2007/5/2/entrez SP - 619 EP - 25 JF - Arthritis and rheumatism JO - Arthritis Rheum. VL - 57 IS - 4 N2 - OBJECTIVE: To determine rates of human papillomavirus (HPV) infections, abnormal cervical smears, and squamous intraepithelial lesions (SIL) among women with systemic lupus erythematosus (SLE). METHODS: We investigated 30 women with SLE, 67 with abnormal smears from colposcopy clinics, and 15 community subjects with normal smears. Polymerase chain reaction results for viral DNA and HPV-16 sequencing data were correlated to cytology and colposcopic findings. RESULTS: SLE and colposcopy patients were more likely (P < 0.05) to be HPV positive (15 [54%] and 37 [67%] patients, respectively) and HPV-16 DNA positive (16 [57%] and 17 [31%] patients, respectively) than community subjects (0% HPV DNA positive and 1 [6%] HPV-16 DNA positive). SLE patients were also more likely to be HPV-16 DNA positive than colposcopy patients (P < 0.05). SLE patients with a high HPV-16 viral load more frequently had SIL (n = 6) than those with a low HPV-16 viral load (n = 1; P < 0.05). HPV and HPV-16 DNA positivity were not associated with previous or current drug therapy for SLE patients. All HPV-16 DNA sequences from 6 SLE and 5 colposcopy patients were the European-type variant. Eighteen (60%) SLE patients had a previous or current cervical abnormality. At the time of study, 5 (17%) SLE patients had an abnormal cervical smear and 8 (27%) had SIL. For those diagnosed with SLE for >10 years, the rate of SIL was 44% lower than those with SLE for <5 years (odds ratio 0.56, 95% confidence interval 0.1-3.5). CONCLUSION: UK women with a recent SLE diagnosis had disturbingly elevated levels of HPV infections (particularly with European HPV-16 variants at a high viral load), abnormal cervical cytology, and SIL. SN - 0004-3591 UR - https://www.unboundmedicine.com/medline/citation/17471531/High_risk_of_human_papillomavirus_type_16_infections_and_of_development_of_cervical_squamous_intraepithelial_lesions_in_systemic_lupus_erythematosus_patients_ L2 - https://doi.org/10.1002/art.22667 DB - PRIME DP - Unbound Medicine ER -