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[Antiendothelial cell antibodies as a risk factor of atherosclerosis in systemic lupus erythematosus].
Ann Acad Med Stetin 2006; 52 Suppl 2:95-9AA

Abstract

PURPOSE

It was confirmed experimentally that antiendothelial cell antibodies (AECA) react directly with the vascular endothelium and are involved in the pathogenesis of vasculitis. There is evidence for a role of AECA in atherosclerosis. To search for correlations between intima-media thickness (IMT) and high titer of AECA in patients with systemic lupus erythematosus (SLE).

MATERIAL AND METHODS

IMT of carotid arteries was measured with B-mode ultrasound in 103 SLE patients and 30 healthy subjects (control group). The presence of AECA was determined with indirect immunofluorescence using human umbilical vein endothelial cells as target. Statistical analysis was performed with chi2 Yates, chi2 Pearson, R Spearman rank test, and logistic multivariate regression analysis.

RESULTS

Normal IMT (< or = 0.65 mm) was found in 34 patients. In 52 patients, IMT was 0.66-0.86 mm and in 17 it exceeded 0.86 mm. The difference in comparison with the control group was significant (p = 0.0002). High titers of AECA were significantly more frequent in patients with SLE than in controls (p = 0.0001). In SLE patients, high titers of AECA correlated with IMT greater than 0.86 mm (OR = 6.61; 95% CI: 1.6-28.3).

CONCLUSIONS

The presence of antiendothelial cell antibodies is a risk factor for premature, subclinical atherosclerosis in patients with SLE.

Authors+Show Affiliations

Klinika Reumatologii Pomorskiej Akademii Medycznej ul. Unii Lubelskiej 1, 71-252 Szczecin.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

pol

PubMed ID

17471843

Citation

Fischer, Katarzyna, et al. "[Antiendothelial Cell Antibodies as a Risk Factor of Atherosclerosis in Systemic Lupus Erythematosus]." Annales Academiae Medicae Stetinensis, vol. 52 Suppl 2, 2006, pp. 95-9.
Fischer K, Brzosko M, Walecka A, et al. [Antiendothelial cell antibodies as a risk factor of atherosclerosis in systemic lupus erythematosus]. Ann Acad Med Stetin. 2006;52 Suppl 2:95-9.
Fischer, K., Brzosko, M., Walecka, A., Ostanek, L., & Sawicki, M. (2006). [Antiendothelial cell antibodies as a risk factor of atherosclerosis in systemic lupus erythematosus]. Annales Academiae Medicae Stetinensis, 52 Suppl 2, pp. 95-9.
Fischer K, et al. [Antiendothelial Cell Antibodies as a Risk Factor of Atherosclerosis in Systemic Lupus Erythematosus]. Ann Acad Med Stetin. 2006;52 Suppl 2:95-9. PubMed PMID: 17471843.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Antiendothelial cell antibodies as a risk factor of atherosclerosis in systemic lupus erythematosus]. AU - Fischer,Katarzyna, AU - Brzosko,Marek, AU - Walecka,Anna, AU - Ostanek,Lidia, AU - Sawicki,Marcin, PY - 2007/5/3/pubmed PY - 2007/6/29/medline PY - 2007/5/3/entrez SP - 95 EP - 9 JF - Annales Academiae Medicae Stetinensis JO - Ann Acad Med Stetin VL - 52 Suppl 2 N2 - PURPOSE: It was confirmed experimentally that antiendothelial cell antibodies (AECA) react directly with the vascular endothelium and are involved in the pathogenesis of vasculitis. There is evidence for a role of AECA in atherosclerosis. To search for correlations between intima-media thickness (IMT) and high titer of AECA in patients with systemic lupus erythematosus (SLE). MATERIAL AND METHODS: IMT of carotid arteries was measured with B-mode ultrasound in 103 SLE patients and 30 healthy subjects (control group). The presence of AECA was determined with indirect immunofluorescence using human umbilical vein endothelial cells as target. Statistical analysis was performed with chi2 Yates, chi2 Pearson, R Spearman rank test, and logistic multivariate regression analysis. RESULTS: Normal IMT (< or = 0.65 mm) was found in 34 patients. In 52 patients, IMT was 0.66-0.86 mm and in 17 it exceeded 0.86 mm. The difference in comparison with the control group was significant (p = 0.0002). High titers of AECA were significantly more frequent in patients with SLE than in controls (p = 0.0001). In SLE patients, high titers of AECA correlated with IMT greater than 0.86 mm (OR = 6.61; 95% CI: 1.6-28.3). CONCLUSIONS: The presence of antiendothelial cell antibodies is a risk factor for premature, subclinical atherosclerosis in patients with SLE. SN - 1427-440X UR - https://www.unboundmedicine.com/medline/citation/17471843/[Antiendothelial_cell_antibodies_as_a_risk_factor_of_atherosclerosis_in_systemic_lupus_erythematosus]_ L2 - http://www.diseaseinfosearch.org/result/9373 DB - PRIME DP - Unbound Medicine ER -