Tags

Type your tag names separated by a space and hit enter

[Three patients with a paraneoplastic neurological syndrome: the significance of paraneoplastic antibodies].
Ned Tijdschr Geneeskd. 2007 Apr 14; 151(15):874-80.NT

Abstract

Establishing the presence of paraneoplastic antibodies is important in identifying an often severe neurological syndrome as paraneoplastic and hence directing the search for an underlying neoplasm. A paraneoplastic neurological syndrome was diagnosed in 3 patients. The first was a 64-year-old woman in whom paraneoplastic encephalomyelitis was diagnosed. The diagnosis was strongly supported by a high titre of serum anti-Hu antibodies, despite three negative biopsies from a mediastinal mass. The patient died of a non-convulsive status epilepticus; autopsy revealed not only paraneoplastic encephalomyelitis but also small-cell lung cancer. The second patient was a 55-year-old woman with metastatic breast cancer. After a three-year period of progressive neurological deterioration, a high titre of anti-CV2/CRMP5 antibodies was detected, on the basis of which the clinical syndrome was diagnosed as paraneoplastic. She received immunotherapy and her condition stabilised. The third patient, a 41-year-old man, presented with severe limbic encephalitis. Biopsy from a paraaortic mass was positive for undifferentiated carcinoma. The patient had a high titre ofanti-Ma2 antibodies and was subsequently tested positive for serum alpha-foetoprotein (AFP) and beta-human-chorionic gonadotrophin (bta-HCG). During chemotherapy for a non seminoma testicular cancer, the limbic encephalitis improved both clinically and radiologically, but the patient died as a result of the toxicity of the treatment.

Authors+Show Affiliations

p.sillevissmitt@erasmusmc.nlNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
English Abstract
Journal Article

Language

dut

PubMed ID

17472120

Citation

Smitt, P A E Sillevis, et al. "[Three Patients With a Paraneoplastic Neurological Syndrome: the Significance of Paraneoplastic Antibodies]." Nederlands Tijdschrift Voor Geneeskunde, vol. 151, no. 15, 2007, pp. 874-80.
Smitt PA, Polman SK, de Beukelaar JW, et al. [Three patients with a paraneoplastic neurological syndrome: the significance of paraneoplastic antibodies]. Ned Tijdschr Geneeskd. 2007;151(15):874-80.
Smitt, P. A., Polman, S. K., de Beukelaar, J. W., Enting, R. H., van den Bent, M. J., Bromberg, J. E., Kros, J. M., & Hooijkaas, H. (2007). [Three patients with a paraneoplastic neurological syndrome: the significance of paraneoplastic antibodies]. Nederlands Tijdschrift Voor Geneeskunde, 151(15), 874-80.
Smitt PA, et al. [Three Patients With a Paraneoplastic Neurological Syndrome: the Significance of Paraneoplastic Antibodies]. Ned Tijdschr Geneeskd. 2007 Apr 14;151(15):874-80. PubMed PMID: 17472120.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Three patients with a paraneoplastic neurological syndrome: the significance of paraneoplastic antibodies]. AU - Smitt,P A E Sillevis, AU - Polman,S K L, AU - de Beukelaar,J W K, AU - Enting,R H, AU - van den Bent,M J, AU - Bromberg,J E, AU - Kros,J M, AU - Hooijkaas,H, PY - 2007/5/3/pubmed PY - 2007/5/30/medline PY - 2007/5/3/entrez SP - 874 EP - 80 JF - Nederlands tijdschrift voor geneeskunde JO - Ned Tijdschr Geneeskd VL - 151 IS - 15 N2 - Establishing the presence of paraneoplastic antibodies is important in identifying an often severe neurological syndrome as paraneoplastic and hence directing the search for an underlying neoplasm. A paraneoplastic neurological syndrome was diagnosed in 3 patients. The first was a 64-year-old woman in whom paraneoplastic encephalomyelitis was diagnosed. The diagnosis was strongly supported by a high titre of serum anti-Hu antibodies, despite three negative biopsies from a mediastinal mass. The patient died of a non-convulsive status epilepticus; autopsy revealed not only paraneoplastic encephalomyelitis but also small-cell lung cancer. The second patient was a 55-year-old woman with metastatic breast cancer. After a three-year period of progressive neurological deterioration, a high titre of anti-CV2/CRMP5 antibodies was detected, on the basis of which the clinical syndrome was diagnosed as paraneoplastic. She received immunotherapy and her condition stabilised. The third patient, a 41-year-old man, presented with severe limbic encephalitis. Biopsy from a paraaortic mass was positive for undifferentiated carcinoma. The patient had a high titre ofanti-Ma2 antibodies and was subsequently tested positive for serum alpha-foetoprotein (AFP) and beta-human-chorionic gonadotrophin (bta-HCG). During chemotherapy for a non seminoma testicular cancer, the limbic encephalitis improved both clinically and radiologically, but the patient died as a result of the toxicity of the treatment. SN - 0028-2162 UR - https://www.unboundmedicine.com/medline/citation/17472120/[Three_patients_with_a_paraneoplastic_neurological_syndrome:_the_significance_of_paraneoplastic_antibodies]_ DB - PRIME DP - Unbound Medicine ER -