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Nutrient intake and risk of squamous cell carcinoma of the esophagus: a case-control study in Uruguay.
Nutr Cancer 2006; 56(2):149-57NC

Abstract

In 1996-2004 a case-control study on nutrient intake, dietary constituents and risk of squamous cell carcinoma of the esophagus was conducted in Montevideo, Uruguay. In fact, Uruguay, and especially its northern provinces, which border Brazil, are high-risk areas. The study included 234 cases and 936 controls. The controls were hospitalized patients with non-neoplastic disease, which was not related to tobacco smoking and alcohol drinking, and without recent changes in their diets. Controls were frequency matched to cases on age (10-yr intervals), sex, and residence (Montevideo and other provinces). Dietary constituents were energy adjusted using the residuals method and then categorized in quartiles according to the distribution of the controls. The final model included linoleic acid, lycopene, alpha-carotene, beta-cryptoxanthin, vitamin A, monounsaturated fat, total carbohydrates, beta-carotene, and folate. The odds ratio (OR) for high intake of linoleic acid was 1.4 (95% confidence interval, CI = 1.2-1.6), whereas lycopene displayed a strong protective effect (OR = 0.7; 95% CI = 0.6-0.9). The possible role of these and other dietary constituents in esophageal carcinogenesis is discussed.

Authors+Show Affiliations

Grupo de Epidemiologia, Departamento de Anatomia Patológica, Hospital de Clínicas, Facultad de Medicina, Montevideo, Uruguay. estefani@adinet.com.uyNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17474860

Citation

De Stefani, Eduardo, et al. "Nutrient Intake and Risk of Squamous Cell Carcinoma of the Esophagus: a Case-control Study in Uruguay." Nutrition and Cancer, vol. 56, no. 2, 2006, pp. 149-57.
De Stefani E, Ronco AL, Boffetta P, et al. Nutrient intake and risk of squamous cell carcinoma of the esophagus: a case-control study in Uruguay. Nutr Cancer. 2006;56(2):149-57.
De Stefani, E., Ronco, A. L., Boffetta, P., Deneo-Pellegrini, H., Acosta, G., Correa, P., & Mendilaharsu, M. (2006). Nutrient intake and risk of squamous cell carcinoma of the esophagus: a case-control study in Uruguay. Nutrition and Cancer, 56(2), pp. 149-57.
De Stefani E, et al. Nutrient Intake and Risk of Squamous Cell Carcinoma of the Esophagus: a Case-control Study in Uruguay. Nutr Cancer. 2006;56(2):149-57. PubMed PMID: 17474860.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Nutrient intake and risk of squamous cell carcinoma of the esophagus: a case-control study in Uruguay. AU - De Stefani,Eduardo, AU - Ronco,Alvaro L, AU - Boffetta,Paolo, AU - Deneo-Pellegrini,Hugo, AU - Acosta,Giselle, AU - Correa,Pelayo, AU - Mendilaharsu,María, PY - 2007/5/4/pubmed PY - 2007/6/26/medline PY - 2007/5/4/entrez SP - 149 EP - 57 JF - Nutrition and cancer JO - Nutr Cancer VL - 56 IS - 2 N2 - In 1996-2004 a case-control study on nutrient intake, dietary constituents and risk of squamous cell carcinoma of the esophagus was conducted in Montevideo, Uruguay. In fact, Uruguay, and especially its northern provinces, which border Brazil, are high-risk areas. The study included 234 cases and 936 controls. The controls were hospitalized patients with non-neoplastic disease, which was not related to tobacco smoking and alcohol drinking, and without recent changes in their diets. Controls were frequency matched to cases on age (10-yr intervals), sex, and residence (Montevideo and other provinces). Dietary constituents were energy adjusted using the residuals method and then categorized in quartiles according to the distribution of the controls. The final model included linoleic acid, lycopene, alpha-carotene, beta-cryptoxanthin, vitamin A, monounsaturated fat, total carbohydrates, beta-carotene, and folate. The odds ratio (OR) for high intake of linoleic acid was 1.4 (95% confidence interval, CI = 1.2-1.6), whereas lycopene displayed a strong protective effect (OR = 0.7; 95% CI = 0.6-0.9). The possible role of these and other dietary constituents in esophageal carcinogenesis is discussed. SN - 0163-5581 UR - https://www.unboundmedicine.com/medline/citation/17474860/Nutrient_intake_and_risk_of_squamous_cell_carcinoma_of_the_esophagus:_a_case_control_study_in_Uruguay_ L2 - http://www.tandfonline.com/doi/full/10.1207/s15327914nc5602_5 DB - PRIME DP - Unbound Medicine ER -