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Marginal zinc deficiency in rats decreases leptin expression independently of food intake and corticotrophin-releasing hormone in relation to food intake.
Br J Nutr. 2007 Sep; 98(3):485-9.BJ

Abstract

Zn deficiency reduces food intake and growth rate in rodents. To determine the relationship between Zn deficiency and the regulation of food intake, we evaluated leptin gene expression in epididymal white adipose tissue (eWAT), and hypothalamic corticotropin-releasing hormone (hCRH) and hypothalamic neuropeptide Y (hNPY) of rats Zn-deficient only to show reduced food intake and growth rate but not food intake cycling. Growing male Sprague-Dawley rats (240 g) were randomly assigned to one of four dietary groups: Zn-adequate (ZA; 30 mg/kg diet), Zn-deficient (ZD; 3 mg/kg diet), pair-fed with ZD (PF; 30 mg/kg diet) and Zn-sufficient (ZS; 50 mg/kg diet) (n 8), and were fed for 3 weeks. Food intake and body weight were measured, as were blood mononuclear cells and pancreas Zn levels. eWAT leptin, hCRH and hNPY mRNA levels were determined. Food intake was decreased by about 10 % in ZD and PF rats compared to ZA and ZS rats. Growth and eWAT leptin mRNA levels were unaffected in PF rats but were significantly (P < 0.05) decreased in ZD rats. However, hNPY showed a tendency to increase, and hCRH significantly (P < 0.05) decreased, in both ZD and PF rats. These results suggest that while leptin gene expression may be directly affected by Zn, hNPY and hCRH are likely responding to reduced food intake caused by Zn deficiency.

Authors+Show Affiliations

Department of Food Science and Nutrition, Andong National University, Andong, Kyungpook, 760-749, South Korea. iskwun@andong.ac.krNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17475084

Citation

Kwun, In-Sook, et al. "Marginal Zinc Deficiency in Rats Decreases Leptin Expression Independently of Food Intake and Corticotrophin-releasing Hormone in Relation to Food Intake." The British Journal of Nutrition, vol. 98, no. 3, 2007, pp. 485-9.
Kwun IS, Cho YE, Lomeda RA, et al. Marginal zinc deficiency in rats decreases leptin expression independently of food intake and corticotrophin-releasing hormone in relation to food intake. Br J Nutr. 2007;98(3):485-9.
Kwun, I. S., Cho, Y. E., Lomeda, R. A., Kwon, S. T., Kim, Y., & Beattie, J. H. (2007). Marginal zinc deficiency in rats decreases leptin expression independently of food intake and corticotrophin-releasing hormone in relation to food intake. The British Journal of Nutrition, 98(3), 485-9.
Kwun IS, et al. Marginal Zinc Deficiency in Rats Decreases Leptin Expression Independently of Food Intake and Corticotrophin-releasing Hormone in Relation to Food Intake. Br J Nutr. 2007;98(3):485-9. PubMed PMID: 17475084.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Marginal zinc deficiency in rats decreases leptin expression independently of food intake and corticotrophin-releasing hormone in relation to food intake. AU - Kwun,In-Sook, AU - Cho,Young-Eun, AU - Lomeda,Ria-Ann R, AU - Kwon,Soon-Tae, AU - Kim,Yangha, AU - Beattie,John H, PY - 2007/5/4/pubmed PY - 2007/10/6/medline PY - 2007/5/4/entrez SP - 485 EP - 9 JF - The British journal of nutrition JO - Br J Nutr VL - 98 IS - 3 N2 - Zn deficiency reduces food intake and growth rate in rodents. To determine the relationship between Zn deficiency and the regulation of food intake, we evaluated leptin gene expression in epididymal white adipose tissue (eWAT), and hypothalamic corticotropin-releasing hormone (hCRH) and hypothalamic neuropeptide Y (hNPY) of rats Zn-deficient only to show reduced food intake and growth rate but not food intake cycling. Growing male Sprague-Dawley rats (240 g) were randomly assigned to one of four dietary groups: Zn-adequate (ZA; 30 mg/kg diet), Zn-deficient (ZD; 3 mg/kg diet), pair-fed with ZD (PF; 30 mg/kg diet) and Zn-sufficient (ZS; 50 mg/kg diet) (n 8), and were fed for 3 weeks. Food intake and body weight were measured, as were blood mononuclear cells and pancreas Zn levels. eWAT leptin, hCRH and hNPY mRNA levels were determined. Food intake was decreased by about 10 % in ZD and PF rats compared to ZA and ZS rats. Growth and eWAT leptin mRNA levels were unaffected in PF rats but were significantly (P < 0.05) decreased in ZD rats. However, hNPY showed a tendency to increase, and hCRH significantly (P < 0.05) decreased, in both ZD and PF rats. These results suggest that while leptin gene expression may be directly affected by Zn, hNPY and hCRH are likely responding to reduced food intake caused by Zn deficiency. SN - 0007-1145 UR - https://www.unboundmedicine.com/medline/citation/17475084/Marginal_zinc_deficiency_in_rats_decreases_leptin_expression_independently_of_food_intake_and_corticotrophin_releasing_hormone_in_relation_to_food_intake_ L2 - https://www.cambridge.org/core/product/identifier/S0007114507730763/type/journal_article DB - PRIME DP - Unbound Medicine ER -