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Amiodarone has anti-inflammatory and anti-oxidative properties: an experimental study in rats with carrageenan-induced paw edema.
Eur J Pharmacol. 2007 Jul 02; 566(1-3):215-21.EJ

Abstract

Amiodarone is a widely used anti-arrhythmic agent. We have investigated alterations in the glutathione (GSH) level and the activities of anti-oxidative enzymes (superoxide dismutase, catalase, glutathione s-transferase and glutathione reductase) and myeloperoxidase, as marker of acute inflammation, following oral administration of amiodarone and diclofenac in rats with carrageenan-induced paw edema. In the present study, we found that 1) Amiodarone reduced the development of carrageenan-induced paw edema, to a greater degree than diclofenac; 2) Amiodarone and diclofenac alleviated increases in the activities of catalase and glutathione s-transferase enzymes resulting from edema; 3) Amiodarone and diclofenac ameliorated depressions in the GSH level and the activities of superoxide dismutase and glutathione reductase enzymes caused by carrageenan injection; and 4) All doses of amiodarone and diclofenac caused an amplification in myeloperoxidase activity resulting from induced paw edema. These results suggest that the anti-inflammatory effect of amiodarone on carrageenan-induced acute inflammation can be attributed to its ameliorating effect on the oxidative damage.

Authors+Show Affiliations

Faculty of Medicine, Department of Pharmacology, Ataturk University, 25240, Erzurum, Turkey. hzekai@atauni.edu.trNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17475238

Citation

Halici, Zekai, et al. "Amiodarone Has Anti-inflammatory and Anti-oxidative Properties: an Experimental Study in Rats With Carrageenan-induced Paw Edema." European Journal of Pharmacology, vol. 566, no. 1-3, 2007, pp. 215-21.
Halici Z, Dengiz GO, Odabasoglu F, et al. Amiodarone has anti-inflammatory and anti-oxidative properties: an experimental study in rats with carrageenan-induced paw edema. Eur J Pharmacol. 2007;566(1-3):215-21.
Halici, Z., Dengiz, G. O., Odabasoglu, F., Suleyman, H., Cadirci, E., & Halici, M. (2007). Amiodarone has anti-inflammatory and anti-oxidative properties: an experimental study in rats with carrageenan-induced paw edema. European Journal of Pharmacology, 566(1-3), 215-21.
Halici Z, et al. Amiodarone Has Anti-inflammatory and Anti-oxidative Properties: an Experimental Study in Rats With Carrageenan-induced Paw Edema. Eur J Pharmacol. 2007 Jul 2;566(1-3):215-21. PubMed PMID: 17475238.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Amiodarone has anti-inflammatory and anti-oxidative properties: an experimental study in rats with carrageenan-induced paw edema. AU - Halici,Zekai, AU - Dengiz,Gunnur Ozbakis, AU - Odabasoglu,Fehmi, AU - Suleyman,Halis, AU - Cadirci,Elif, AU - Halici,Mesut, Y1 - 2007/04/05/ PY - 2006/12/11/received PY - 2007/03/19/revised PY - 2007/03/25/accepted PY - 2007/5/4/pubmed PY - 2007/9/20/medline PY - 2007/5/4/entrez SP - 215 EP - 21 JF - European journal of pharmacology JO - Eur J Pharmacol VL - 566 IS - 1-3 N2 - Amiodarone is a widely used anti-arrhythmic agent. We have investigated alterations in the glutathione (GSH) level and the activities of anti-oxidative enzymes (superoxide dismutase, catalase, glutathione s-transferase and glutathione reductase) and myeloperoxidase, as marker of acute inflammation, following oral administration of amiodarone and diclofenac in rats with carrageenan-induced paw edema. In the present study, we found that 1) Amiodarone reduced the development of carrageenan-induced paw edema, to a greater degree than diclofenac; 2) Amiodarone and diclofenac alleviated increases in the activities of catalase and glutathione s-transferase enzymes resulting from edema; 3) Amiodarone and diclofenac ameliorated depressions in the GSH level and the activities of superoxide dismutase and glutathione reductase enzymes caused by carrageenan injection; and 4) All doses of amiodarone and diclofenac caused an amplification in myeloperoxidase activity resulting from induced paw edema. These results suggest that the anti-inflammatory effect of amiodarone on carrageenan-induced acute inflammation can be attributed to its ameliorating effect on the oxidative damage. SN - 0014-2999 UR - https://www.unboundmedicine.com/medline/citation/17475238/Amiodarone_has_anti_inflammatory_and_anti_oxidative_properties:_an_experimental_study_in_rats_with_carrageenan_induced_paw_edema_ DB - PRIME DP - Unbound Medicine ER -