Tags

Type your tag names separated by a space and hit enter

Diabetes mellitus and risk of endometrial cancer: a meta-analysis.
Diabetologia 2007; 50(7):1365-74D

Abstract

AIMS/HYPOTHESIS

Diabetes has been associated with a statistically significantly increased risk of endometrial cancer in most, but not all studies. To provide a quantitative assessment of the association between diabetes and risk of endometrial cancer, we conducted a meta-analysis of case-control studies and cohort studies.

SUBJECTS AND METHODS

We identified studies by a literature search of PubMed and Embase through to January 2007 and by searching the reference lists of relevant articles. Summary relative risks (RRs) with 95% CIs were calculated using random-effects model.

RESULTS

The analysis of diabetes (largely type 2) and endometrial cancer is based on 16 studies (three cohort and 13 case-control studies), including 96,003 participants and 7,596 cases of endometrial cancer. Twelve of the studies showed a statistically significantly increased risk and four a non-significant increased risk of endometrial cancer. In our meta-analysis we found that diabetes was statistically significantly associated with an increased risk of endometrial cancer (summary RR 2.10, 95% CI 1.75-2.53). The risk estimates were somewhat stronger among case-control (RR 2.22, 95% CI 1.80-2.74) than among cohort studies (RR 1.62, 95% CI 1.21-2.16), stronger among studies adjusting only for age (RR 2.74, 95% CI 1.87-4.00) compared with multivariate adjustment (RR 1.92, 95% CI 1.58-2.33) and slightly lower in studies performed in the USA than in those performed Europe. The analysis of type 1 diabetes and endometrial cancer was based on three studies and found a statistically significant positive association (summary RR 3.15, 95%CI 1.07-9.29).

CONCLUSIONS/INTERPRETATION

Results from the meta-analysis support a relationship between diabetes and increased risk of endometrial cancer.

Authors+Show Affiliations

Division of Nutritional Epidemiology, The National Institute of Environmental Medicine, Karolinska Institutet, PO Box 210, 171 77, Stockholm, Sweden. emilie.friberg@ki.seNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17476474

Citation

Friberg, E, et al. "Diabetes Mellitus and Risk of Endometrial Cancer: a Meta-analysis." Diabetologia, vol. 50, no. 7, 2007, pp. 1365-74.
Friberg E, Orsini N, Mantzoros CS, et al. Diabetes mellitus and risk of endometrial cancer: a meta-analysis. Diabetologia. 2007;50(7):1365-74.
Friberg, E., Orsini, N., Mantzoros, C. S., & Wolk, A. (2007). Diabetes mellitus and risk of endometrial cancer: a meta-analysis. Diabetologia, 50(7), pp. 1365-74.
Friberg E, et al. Diabetes Mellitus and Risk of Endometrial Cancer: a Meta-analysis. Diabetologia. 2007;50(7):1365-74. PubMed PMID: 17476474.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diabetes mellitus and risk of endometrial cancer: a meta-analysis. AU - Friberg,E, AU - Orsini,N, AU - Mantzoros,C S, AU - Wolk,A, Y1 - 2007/05/03/ PY - 2006/12/19/received PY - 2007/03/15/accepted PY - 2007/5/4/pubmed PY - 2007/11/8/medline PY - 2007/5/4/entrez SP - 1365 EP - 74 JF - Diabetologia JO - Diabetologia VL - 50 IS - 7 N2 - AIMS/HYPOTHESIS: Diabetes has been associated with a statistically significantly increased risk of endometrial cancer in most, but not all studies. To provide a quantitative assessment of the association between diabetes and risk of endometrial cancer, we conducted a meta-analysis of case-control studies and cohort studies. SUBJECTS AND METHODS: We identified studies by a literature search of PubMed and Embase through to January 2007 and by searching the reference lists of relevant articles. Summary relative risks (RRs) with 95% CIs were calculated using random-effects model. RESULTS: The analysis of diabetes (largely type 2) and endometrial cancer is based on 16 studies (three cohort and 13 case-control studies), including 96,003 participants and 7,596 cases of endometrial cancer. Twelve of the studies showed a statistically significantly increased risk and four a non-significant increased risk of endometrial cancer. In our meta-analysis we found that diabetes was statistically significantly associated with an increased risk of endometrial cancer (summary RR 2.10, 95% CI 1.75-2.53). The risk estimates were somewhat stronger among case-control (RR 2.22, 95% CI 1.80-2.74) than among cohort studies (RR 1.62, 95% CI 1.21-2.16), stronger among studies adjusting only for age (RR 2.74, 95% CI 1.87-4.00) compared with multivariate adjustment (RR 1.92, 95% CI 1.58-2.33) and slightly lower in studies performed in the USA than in those performed Europe. The analysis of type 1 diabetes and endometrial cancer was based on three studies and found a statistically significant positive association (summary RR 3.15, 95%CI 1.07-9.29). CONCLUSIONS/INTERPRETATION: Results from the meta-analysis support a relationship between diabetes and increased risk of endometrial cancer. SN - 0012-186X UR - https://www.unboundmedicine.com/medline/citation/17476474/full_citation L2 - https://dx.doi.org/10.1007/s00125-007-0681-5 DB - PRIME DP - Unbound Medicine ER -