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[Concentration of ferritin, transferrin and iron as a markers of iron deficiency in healthy women in reproductive age].
Pol Merkur Lekarski 2007; 22(127):25-7PM

Abstract

Iron deficiency anemia in pregnancy continues to be a clinical problem, which contributes to maternal and fetal morbidity. Iron store deficiency leads to iron deficient erythropoiesis and to negative iron balance when the iron supply is insufficient to maintain normal concentration of hemoglobin. The aim of this study was aimed to establish concentration of ferritin, transferrin and iron as a markers of iron deficiency in healthy women in reproductive age came for control examination to Institute of Mother and Child in Warsaw.

MATERIAL AND METHODS

In serum of 108 healthy, multiparas in age up to 40 years from urban agglomerations, middle-class non-pregnant women concentration of iron, ferritin, transferrin and transferrin saturation were determined by commercially available kits (Hoffman-La Roche, Switzerland).

RESULTS

Mean concentration of iron, ferritin and transferrin were among normal values. Low level of iron (below 49 microg/dl) was observed in serum of 12%, this of ferritin (below 20 ng/ml) in 22% and of transferrin (below 252 mg/dl) in 15% of studied women. Transferrin saturation lower than 15% was observed in 9 patients. The obtained values were age dependent. The lowest values of total iron were observed in the youngest group I (below 25 years old) and were accompanied with ferritin level below 20 ng/ml in 26% of women. Low ferritin values were also observed in serum of 22% patients of group II (25-35 years old) and only in 14% of women older than 35 years (group III). Saturation of transferrin lower than 15%, which indicated deficiency of iron for erythropoiesis, was observed in 26%, 13% and 19% patients of group I, II and III respectively.

CONCLUSIONS

Obtained results indicated that in population of studied women in reproductive age, subclinical iron deficiency in 20% and negative iron balance in 10% could be observed. Therefore, iron status, especially store ferritin, should be assessed very carefully as a component of medical care.

Authors+Show Affiliations

Department of Biochemistry and Clinical Diagnostics, Institute of Mother and Child, Poland. lipidy@imid.med.plNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

pol

PubMed ID

17477085

Citation

Chełchowska, Magdalena, et al. "[Concentration of Ferritin, Transferrin and Iron as a Markers of Iron Deficiency in Healthy Women in Reproductive Age]." Polski Merkuriusz Lekarski : Organ Polskiego Towarzystwa Lekarskiego, vol. 22, no. 127, 2007, pp. 25-7.
Chełchowska M, Laskowska-Klita T, Leibschang J. [Concentration of ferritin, transferrin and iron as a markers of iron deficiency in healthy women in reproductive age]. Pol Merkur Lekarski. 2007;22(127):25-7.
Chełchowska, M., Laskowska-Klita, T., & Leibschang, J. (2007). [Concentration of ferritin, transferrin and iron as a markers of iron deficiency in healthy women in reproductive age]. Polski Merkuriusz Lekarski : Organ Polskiego Towarzystwa Lekarskiego, 22(127), pp. 25-7.
Chełchowska M, Laskowska-Klita T, Leibschang J. [Concentration of Ferritin, Transferrin and Iron as a Markers of Iron Deficiency in Healthy Women in Reproductive Age]. Pol Merkur Lekarski. 2007;22(127):25-7. PubMed PMID: 17477085.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Concentration of ferritin, transferrin and iron as a markers of iron deficiency in healthy women in reproductive age]. AU - Chełchowska,Magdalena, AU - Laskowska-Klita,Teresa, AU - Leibschang,Jerzy, PY - 2007/5/5/pubmed PY - 2007/6/9/medline PY - 2007/5/5/entrez SP - 25 EP - 7 JF - Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego JO - Pol. Merkur. Lekarski VL - 22 IS - 127 N2 - UNLABELLED: Iron deficiency anemia in pregnancy continues to be a clinical problem, which contributes to maternal and fetal morbidity. Iron store deficiency leads to iron deficient erythropoiesis and to negative iron balance when the iron supply is insufficient to maintain normal concentration of hemoglobin. The aim of this study was aimed to establish concentration of ferritin, transferrin and iron as a markers of iron deficiency in healthy women in reproductive age came for control examination to Institute of Mother and Child in Warsaw. MATERIAL AND METHODS: In serum of 108 healthy, multiparas in age up to 40 years from urban agglomerations, middle-class non-pregnant women concentration of iron, ferritin, transferrin and transferrin saturation were determined by commercially available kits (Hoffman-La Roche, Switzerland). RESULTS: Mean concentration of iron, ferritin and transferrin were among normal values. Low level of iron (below 49 microg/dl) was observed in serum of 12%, this of ferritin (below 20 ng/ml) in 22% and of transferrin (below 252 mg/dl) in 15% of studied women. Transferrin saturation lower than 15% was observed in 9 patients. The obtained values were age dependent. The lowest values of total iron were observed in the youngest group I (below 25 years old) and were accompanied with ferritin level below 20 ng/ml in 26% of women. Low ferritin values were also observed in serum of 22% patients of group II (25-35 years old) and only in 14% of women older than 35 years (group III). Saturation of transferrin lower than 15%, which indicated deficiency of iron for erythropoiesis, was observed in 26%, 13% and 19% patients of group I, II and III respectively. CONCLUSIONS: Obtained results indicated that in population of studied women in reproductive age, subclinical iron deficiency in 20% and negative iron balance in 10% could be observed. Therefore, iron status, especially store ferritin, should be assessed very carefully as a component of medical care. SN - 1426-9686 UR - https://www.unboundmedicine.com/medline/citation/17477085/[Concentration_of_ferritin_transferrin_and_iron_as_a_markers_of_iron_deficiency_in_healthy_women_in_reproductive_age]_ L2 - https://medlineplus.gov/healthproblemsinpregnancy.html DB - PRIME DP - Unbound Medicine ER -