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Parvovirus B19 may have a role in the pathogenesis of juvenile idiopathic arthritis.
J Rheumatol. 2007 Jun; 34(6):1336-40.JR

Abstract

OBJECTIVE

To determine the prevalence of human parvovirus B19 infection in patients with juvenile idiopathic arthritis (JIA) by detection of specific IgM, IgG, and viral DNA.

METHODS

Serum samples of 50 patients with diagnosis of JIA and 39 healthy controls were analyzed by ELISA to detect IgG and IgM anti-B19-specific antibodies. The parvovirus B19 genome was detected by nested polymerase chain reaction (PCR). The average age of the patients was 9.6 years (2-14 yrs); 30 were female (60%) and 20 male (40%). The definitive diagnoses of these patients corresponded to 19 systemic forms (38%), 11 to the oligoarticular variety (22%) and 20 to the polyarticular (40%). The average age of the control group was 7.8 years (2-16 yrs); the distribution by sex was 25 females (64%) and 14 males (36%).

RESULTS

IgM against parvovirus B19 was detected in 20% of the cases (10 patients) and B19 DNA genome by PCR in 48% (24 patients); in 10% of the cases (5 patients), both markers were detected. IgG was found in 32% (16 patients). In the control group neither IgM nor the viral genome was detected. However, 43.5% of the controls (17/39) had IgG against parvovirus B19, indicating past infection by the virus.

CONCLUSION

Our study confirms recent observations regarding a high prevalence of viral DNA in JIA patients and a possible role of this viral infection in JIA pathogenesis.

Authors+Show Affiliations

Immunology Unit, Luis Calvo Mackenna Hospital, Santiago, Chile.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17477467

Citation

Gonzalez, Benito, et al. "Parvovirus B19 May Have a Role in the Pathogenesis of Juvenile Idiopathic Arthritis." The Journal of Rheumatology, vol. 34, no. 6, 2007, pp. 1336-40.
Gonzalez B, Larrañaga C, León O, et al. Parvovirus B19 may have a role in the pathogenesis of juvenile idiopathic arthritis. J Rheumatol. 2007;34(6):1336-40.
Gonzalez, B., Larrañaga, C., León, O., Díaz, P., Miranda, M., Barría, M., & Gaggero, A. (2007). Parvovirus B19 may have a role in the pathogenesis of juvenile idiopathic arthritis. The Journal of Rheumatology, 34(6), 1336-40.
Gonzalez B, et al. Parvovirus B19 May Have a Role in the Pathogenesis of Juvenile Idiopathic Arthritis. J Rheumatol. 2007;34(6):1336-40. PubMed PMID: 17477467.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Parvovirus B19 may have a role in the pathogenesis of juvenile idiopathic arthritis. AU - Gonzalez,Benito, AU - Larrañaga,Carmen, AU - León,Oscar, AU - Díaz,Patricia, AU - Miranda,Marta, AU - Barría,Marcelo, AU - Gaggero,Aldo, Y1 - 2007/05/01/ PY - 2007/5/5/pubmed PY - 2007/8/31/medline PY - 2007/5/5/entrez SP - 1336 EP - 40 JF - The Journal of rheumatology JO - J Rheumatol VL - 34 IS - 6 N2 - OBJECTIVE: To determine the prevalence of human parvovirus B19 infection in patients with juvenile idiopathic arthritis (JIA) by detection of specific IgM, IgG, and viral DNA. METHODS: Serum samples of 50 patients with diagnosis of JIA and 39 healthy controls were analyzed by ELISA to detect IgG and IgM anti-B19-specific antibodies. The parvovirus B19 genome was detected by nested polymerase chain reaction (PCR). The average age of the patients was 9.6 years (2-14 yrs); 30 were female (60%) and 20 male (40%). The definitive diagnoses of these patients corresponded to 19 systemic forms (38%), 11 to the oligoarticular variety (22%) and 20 to the polyarticular (40%). The average age of the control group was 7.8 years (2-16 yrs); the distribution by sex was 25 females (64%) and 14 males (36%). RESULTS: IgM against parvovirus B19 was detected in 20% of the cases (10 patients) and B19 DNA genome by PCR in 48% (24 patients); in 10% of the cases (5 patients), both markers were detected. IgG was found in 32% (16 patients). In the control group neither IgM nor the viral genome was detected. However, 43.5% of the controls (17/39) had IgG against parvovirus B19, indicating past infection by the virus. CONCLUSION: Our study confirms recent observations regarding a high prevalence of viral DNA in JIA patients and a possible role of this viral infection in JIA pathogenesis. SN - 0315-162X UR - https://www.unboundmedicine.com/medline/citation/17477467/Parvovirus_B19_may_have_a_role_in_the_pathogenesis_of_juvenile_idiopathic_arthritis_ L2 - http://www.jrheum.org/cgi/pmidlookup?view=long&pmid=17477467 DB - PRIME DP - Unbound Medicine ER -