Tags

Type your tag names separated by a space and hit enter

LAST II: Differential temporal responses of macular pigment optical density in patients with atrophic age-related macular degeneration to dietary supplementation with xanthophylls.
Optometry 2007; 78(5):213-9O

Abstract

BACKGROUND

Age-related macular degeneration (ARMD) is the leading cause of vision loss in aging Western societies. The objective of the Lutein Antioxidant Supplementation Trial (LAST) was to determine whether specific dietary interventions increased macular pigment optical density (MPOD) and visual function in patients with atrophic ARMD. The current objective of LAST II is to discern those specific characteristics that increase MPOD, i.e., that might differentiate a responder from a nonresponder.

METHODS

The LAST study was a prospective, 12-month, randomized, double-masked, placebo-controlled trial conducted at an urban midwestern Veterans Administation Hospital from August 1999 to May 2001. Ninety patients with atrophic ARMD entered the study and were assigned randomly to 1 of 3 groups. Patients in group 1 received 10 mg lutein; in group 2, 10 mg lutein in combination with vitamins, minerals, and antioxidants; and in group 3, maltodextrin placebo. Changes in macular MPOD over time were evaluated. Characteristics potentially influencing MPOD included age, weight (body mass index), initial baseline values of macular pigment, and combining xanthophylls with other nutrients.

RESULTS

MPOD increased with supplementation and declined slightly without supplementation (regression slopes not equal to zero in supplemented groups, P < 0.02). The highest increases in MPOD over time occurred in patients with lower baseline values of MPOD. Statistically significant increases in MPOD density were observed in the lutein group for patients with baseline MPOD <or=0.3 optical density units and up to 0.2 optical density units in the lutein plus antioxidant group. Further analysis found that none of the subjects' eyes in the lowest quartile of baseline MPOD were in the lowest quartile for change in MPOD.

CONCLUSION

Noteworthy is the observation that those individuals with lowest MPOD, and in greatest need of supplementation, were also most likely to benefit from either the lutein or the lutein plus antioxidant supplementation. For those individuals who responded to supplementation, their macular pigment optical density had not ceased to increase at 12 months' duration of supplementation. The inference is that if a deficiency in macular pigment optical density is accurately diagnosed, effective interventions should be able to re-establish this prophylactic barrier.

Authors+Show Affiliations

Department of Veterans Affairs, Medical Center Eye Clinic, North Chicago, Illinois 60064-3095, USA. Stuart.Richer1@va.govNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

17478338

Citation

Richer, Stuart, et al. "LAST II: Differential Temporal Responses of Macular Pigment Optical Density in Patients With Atrophic Age-related Macular Degeneration to Dietary Supplementation With Xanthophylls." Optometry (St. Louis, Mo.), vol. 78, no. 5, 2007, pp. 213-9.
Richer S, Devenport J, Lang JC. LAST II: Differential temporal responses of macular pigment optical density in patients with atrophic age-related macular degeneration to dietary supplementation with xanthophylls. Optometry. 2007;78(5):213-9.
Richer, S., Devenport, J., & Lang, J. C. (2007). LAST II: Differential temporal responses of macular pigment optical density in patients with atrophic age-related macular degeneration to dietary supplementation with xanthophylls. Optometry (St. Louis, Mo.), 78(5), pp. 213-9.
Richer S, Devenport J, Lang JC. LAST II: Differential Temporal Responses of Macular Pigment Optical Density in Patients With Atrophic Age-related Macular Degeneration to Dietary Supplementation With Xanthophylls. Optometry. 2007;78(5):213-9. PubMed PMID: 17478338.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - LAST II: Differential temporal responses of macular pigment optical density in patients with atrophic age-related macular degeneration to dietary supplementation with xanthophylls. AU - Richer,Stuart, AU - Devenport,Jenny, AU - Lang,John C, PY - 2006/03/01/received PY - 2006/07/19/revised PY - 2006/10/20/accepted PY - 2007/5/5/pubmed PY - 2007/6/29/medline PY - 2007/5/5/entrez SP - 213 EP - 9 JF - Optometry (St. Louis, Mo.) JO - Optometry VL - 78 IS - 5 N2 - BACKGROUND: Age-related macular degeneration (ARMD) is the leading cause of vision loss in aging Western societies. The objective of the Lutein Antioxidant Supplementation Trial (LAST) was to determine whether specific dietary interventions increased macular pigment optical density (MPOD) and visual function in patients with atrophic ARMD. The current objective of LAST II is to discern those specific characteristics that increase MPOD, i.e., that might differentiate a responder from a nonresponder. METHODS: The LAST study was a prospective, 12-month, randomized, double-masked, placebo-controlled trial conducted at an urban midwestern Veterans Administation Hospital from August 1999 to May 2001. Ninety patients with atrophic ARMD entered the study and were assigned randomly to 1 of 3 groups. Patients in group 1 received 10 mg lutein; in group 2, 10 mg lutein in combination with vitamins, minerals, and antioxidants; and in group 3, maltodextrin placebo. Changes in macular MPOD over time were evaluated. Characteristics potentially influencing MPOD included age, weight (body mass index), initial baseline values of macular pigment, and combining xanthophylls with other nutrients. RESULTS: MPOD increased with supplementation and declined slightly without supplementation (regression slopes not equal to zero in supplemented groups, P < 0.02). The highest increases in MPOD over time occurred in patients with lower baseline values of MPOD. Statistically significant increases in MPOD density were observed in the lutein group for patients with baseline MPOD <or=0.3 optical density units and up to 0.2 optical density units in the lutein plus antioxidant group. Further analysis found that none of the subjects' eyes in the lowest quartile of baseline MPOD were in the lowest quartile for change in MPOD. CONCLUSION: Noteworthy is the observation that those individuals with lowest MPOD, and in greatest need of supplementation, were also most likely to benefit from either the lutein or the lutein plus antioxidant supplementation. For those individuals who responded to supplementation, their macular pigment optical density had not ceased to increase at 12 months' duration of supplementation. The inference is that if a deficiency in macular pigment optical density is accurately diagnosed, effective interventions should be able to re-establish this prophylactic barrier. SN - 1529-1839 UR - https://www.unboundmedicine.com/medline/citation/17478338/LAST_II:_Differential_temporal_responses_of_macular_pigment_optical_density_in_patients_with_atrophic_age_related_macular_degeneration_to_dietary_supplementation_with_xanthophylls_ L2 - https://ClinicalTrials.gov/search/term=17478338 [PUBMED-IDS] DB - PRIME DP - Unbound Medicine ER -