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Microcirculatory effects of Viatromb spray gel heparin in chronic venous insufficiency: evaluation of TcPO2 and PCO2--a product evaluation study.
Angiology. 2007 Apr-May; 58 Suppl 1:21S-26S.A

Abstract

The evolution of microcirculatory methods and the definition of the concept of venous microangiopathy allow the study in a quantitative way of microcirculatory changes produced by pharmacologic treatments at the areas most frequently and severely affected by chronic venous insufficiency (CVI), venous hypertensive microangiopathy, and venous ulcerations. This pilot study compares subjects with CVI, in the area most affected by venous hypertension in a 2-week registry. Elastic compression, compression plus Viatromb (lyposomal spray gel heparin), Lioton (gel including heparin), and Viatromb alone were compared. Subjects were evaluated for laser Doppler flux, transcutaneous partial pressure of oxygen (TcPO2), and partial pressure of carbon dioxide (PCO2) and CVI analogic symptom scale. In the Viatromb groups (B and D), significant decreases in laser Doppler flux, PCO2, and CVI score were observed. The decrease was proportionally more important in the elastic compression plus Viatromb group. Partial pressure of oxygen (PO2) was significantly increased. No significant changes were observed in the Lioton group. There was a good effect for compression only. These differences are significant, as they can be observed even in small groups (10-15 patients). No treatment side effects were observed, and compliance and tolerability were very good.

Authors+Show Affiliations

Irvine2 Vascular Lab and Physiology, Department of Biomedical Sciences, G. D'Annunzio, Chieti-Pescara University.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article

Language

eng

PubMed ID

17478879

Citation

Rosaria Cesarone, Maria, et al. "Microcirculatory Effects of Viatromb Spray Gel Heparin in Chronic Venous Insufficiency: Evaluation of TcPO2 and PCO2--a Product Evaluation Study." Angiology, vol. 58 Suppl 1, 2007, 21S-26S.
Rosaria Cesarone M, Belcaro G, Errichi S, et al. Microcirculatory effects of Viatromb spray gel heparin in chronic venous insufficiency: evaluation of TcPO2 and PCO2--a product evaluation study. Angiology. 2007;58 Suppl 1:21S-26S.
Rosaria Cesarone, M., Belcaro, G., Errichi, S., Pellegrini, L., Ledda, A., Vinciguerra, G., Ricci, A., Gizzi, G., Ippolito, E., Fano, F., Dugall, M., Acerbi, G., Cacchio, M., Di Renzo, A., Hosoi, M., Stuard, S., & Corsi, M. (2007). Microcirculatory effects of Viatromb spray gel heparin in chronic venous insufficiency: evaluation of TcPO2 and PCO2--a product evaluation study. Angiology, 58 Suppl 1, 21S-26S.
Rosaria Cesarone M, et al. Microcirculatory Effects of Viatromb Spray Gel Heparin in Chronic Venous Insufficiency: Evaluation of TcPO2 and PCO2--a Product Evaluation Study. Angiology. 2007 Apr-May;58 Suppl 1:21S-26S. PubMed PMID: 17478879.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Microcirculatory effects of Viatromb spray gel heparin in chronic venous insufficiency: evaluation of TcPO2 and PCO2--a product evaluation study. AU - Rosaria Cesarone,Maria, AU - Belcaro,Gianni, AU - Errichi,Silvia, AU - Pellegrini,Luciano, AU - Ledda,Andrea, AU - Vinciguerra,Giulia, AU - Ricci,Andrea, AU - Gizzi,Giuseppe, AU - Ippolito,Edmondo, AU - Fano,Filiberto, AU - Dugall,Mark, AU - Acerbi,Giovanni, AU - Cacchio,Marisa, AU - Di Renzo,Andrea, AU - Hosoi,Morio, AU - Stuard,Stefano, AU - Corsi,Marcello, PY - 2007/5/5/pubmed PY - 2008/9/19/medline PY - 2007/5/5/entrez SP - 21S EP - 26S JF - Angiology JO - Angiology VL - 58 Suppl 1 N2 - The evolution of microcirculatory methods and the definition of the concept of venous microangiopathy allow the study in a quantitative way of microcirculatory changes produced by pharmacologic treatments at the areas most frequently and severely affected by chronic venous insufficiency (CVI), venous hypertensive microangiopathy, and venous ulcerations. This pilot study compares subjects with CVI, in the area most affected by venous hypertension in a 2-week registry. Elastic compression, compression plus Viatromb (lyposomal spray gel heparin), Lioton (gel including heparin), and Viatromb alone were compared. Subjects were evaluated for laser Doppler flux, transcutaneous partial pressure of oxygen (TcPO2), and partial pressure of carbon dioxide (PCO2) and CVI analogic symptom scale. In the Viatromb groups (B and D), significant decreases in laser Doppler flux, PCO2, and CVI score were observed. The decrease was proportionally more important in the elastic compression plus Viatromb group. Partial pressure of oxygen (PO2) was significantly increased. No significant changes were observed in the Lioton group. There was a good effect for compression only. These differences are significant, as they can be observed even in small groups (10-15 patients). No treatment side effects were observed, and compliance and tolerability were very good. SN - 0003-3197 UR - https://www.unboundmedicine.com/medline/citation/17478879/Microcirculatory_effects_of_Viatromb_spray_gel_heparin_in_chronic_venous_insufficiency:_evaluation_of_TcPO2_and_PCO2__a_product_evaluation_study_ L2 - https://journals.sagepub.com/doi/10.1177/0003319706297625?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -