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[Azoospermia factor microdeletion on Y chromosome in patients with idiopathic azoospermia or severe oligozoospermia].
Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2007 Apr; 32(2):241-5.ZN

Abstract

OBJECTIVE

To investigate the correlation between male infertility and Y chromosome microdeletions of azoospermia factor (AZF) regions, and to establish a reliable genetic diagnosis in idiopathic infertile male patients with azoospermia or severe oligozoospermia.

METHODS

Multiplex PCR amplification of 6 sequence-tagged sites in AZF regions of the Y chromosome was examined among 100 normal karyotype male patients with azoospermia or oligozoospermia.

RESULTS

Four patients (4%) had Y chromosome microdeletions, the microdeletions of 3 patients were idiopathic azoospermic and those of the other 1 patient were secretory azoospermia.

CONCLUSION

The PCR-based Y chromosome microdeletion screening is simple and effective in the diagnosis of patients with severe male infertility. Microdeletion of Y chromosome is one of the major causes of severe dyszooospermia.

Authors+Show Affiliations

National Laboratory of Medical Genetics of China, Xiangya Hospital, Central South University, Changsha, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

17478930

Citation

Hu, Lan-Ping, et al. "[Azoospermia Factor Microdeletion On Y Chromosome in Patients With Idiopathic Azoospermia or Severe Oligozoospermia]." Zhong Nan Da Xue Xue Bao. Yi Xue Ban = Journal of Central South University. Medical Sciences, vol. 32, no. 2, 2007, pp. 241-5.
Hu LP, Liu NH, Pan Q, et al. [Azoospermia factor microdeletion on Y chromosome in patients with idiopathic azoospermia or severe oligozoospermia]. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2007;32(2):241-5.
Hu, L. P., Liu, N. H., Pan, Q., Liang, D. S., Long, Z. G., Hu, H., Zhu, H. Y., Dai, H. P., Cai, F., Wu, L. Q., Xia, K., & Xia, J. H. (2007). [Azoospermia factor microdeletion on Y chromosome in patients with idiopathic azoospermia or severe oligozoospermia]. Zhong Nan Da Xue Xue Bao. Yi Xue Ban = Journal of Central South University. Medical Sciences, 32(2), 241-5.
Hu LP, et al. [Azoospermia Factor Microdeletion On Y Chromosome in Patients With Idiopathic Azoospermia or Severe Oligozoospermia]. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2007;32(2):241-5. PubMed PMID: 17478930.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Azoospermia factor microdeletion on Y chromosome in patients with idiopathic azoospermia or severe oligozoospermia]. AU - Hu,Lan-Ping, AU - Liu,Neng-Hui, AU - Pan,Qian, AU - Liang,De-Sheng, AU - Long,Zhi-Gao, AU - Hu,Hao, AU - Zhu,Hai-Yan, AU - Dai,He-Ping, AU - Cai,Fang, AU - Wu,Ling-Qian, AU - Xia,Kun, AU - Xia,Jia-Hui, PY - 2007/5/5/pubmed PY - 2008/4/22/medline PY - 2007/5/5/entrez SP - 241 EP - 5 JF - Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences JO - Zhong Nan Da Xue Xue Bao Yi Xue Ban VL - 32 IS - 2 N2 - OBJECTIVE: To investigate the correlation between male infertility and Y chromosome microdeletions of azoospermia factor (AZF) regions, and to establish a reliable genetic diagnosis in idiopathic infertile male patients with azoospermia or severe oligozoospermia. METHODS: Multiplex PCR amplification of 6 sequence-tagged sites in AZF regions of the Y chromosome was examined among 100 normal karyotype male patients with azoospermia or oligozoospermia. RESULTS: Four patients (4%) had Y chromosome microdeletions, the microdeletions of 3 patients were idiopathic azoospermic and those of the other 1 patient were secretory azoospermia. CONCLUSION: The PCR-based Y chromosome microdeletion screening is simple and effective in the diagnosis of patients with severe male infertility. Microdeletion of Y chromosome is one of the major causes of severe dyszooospermia. SN - 1672-7347 UR - https://www.unboundmedicine.com/medline/citation/17478930/[Azoospermia_factor_microdeletion_on_Y_chromosome_in_patients_with_idiopathic_azoospermia_or_severe_oligozoospermia]_ L2 - http://xbyxb.csu.edu.cn/xbwk/fileup/PDF/200704241.pdf DB - PRIME DP - Unbound Medicine ER -