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Outbreak of chikungunya on Reunion Island: early clinical and laboratory features in 157 adult patients.
Clin Infect Dis. 2007 Jun 01; 44(11):1401-7.CI

Abstract

BACKGROUND

Chikungunya is a reemerging disease. In 2005-2006, a severe outbreak occurred on Reunion Island in the southwestern part of the Indian Ocean. Other islands in this area were affected during the same period.

METHODS

Adult patients with acute chikungunya (defined as onset of fever and/or polyarthralgia in the 5 days preceding consultation) and laboratory-confirmed chikungunya who were referred to Groupe Hospitalier Sud Reunion during the period from March 2005 through April 2006 were included in this retrospective study. Their clinical and laboratory features are reported.

RESULTS

Laboratory-confirmed acute chikungunya was documented in 157 patients. The mean age of patients was 57.9 years, and the ratio of male to female patients was 1.24 : 1. Sixty percent of patients had at least 1 comorbidity. Ninety-seven patients (61.8%) were hospitalized, and 60 (38.2%) were treated as outpatients. Five fatalities were reported. One hundred fifty-one patients (96.1%) experienced polyarthralgia, and 129 (89%) experienced fever. Gastrointestinal symptoms were reported by 74 patients (47.1%), and skin rash was reported by 63 (40.1%). Hemorrhagic signs were rare. Lymphopenia and hypocalcemia were the prominent laboratory findings. Severe thrombocytopenia was rarely observed.

CONCLUSIONS

Chikungunya virus can be responsible for explosive outbreaks of disease. Polyarthralgia and fever are the 2 main clinical features. In this era of travel and globalization, chikungunya should be considered in the differential diagnosis of febrile polyarthralgia with an abrupt onset.

Authors+Show Affiliations

Service de Pneumologie et Maladies Infectieuses, Groupe Hospitalier Sud Reunion, Saint Pierre, La Reunion, France. gianu.borg@wanadoo.frNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17479933

Citation

Borgherini, Gianandrea, et al. "Outbreak of Chikungunya On Reunion Island: Early Clinical and Laboratory Features in 157 Adult Patients." Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America, vol. 44, no. 11, 2007, pp. 1401-7.
Borgherini G, Poubeau P, Staikowsky F, et al. Outbreak of chikungunya on Reunion Island: early clinical and laboratory features in 157 adult patients. Clin Infect Dis. 2007;44(11):1401-7.
Borgherini, G., Poubeau, P., Staikowsky, F., Lory, M., Le Moullec, N., Becquart, J. P., Wengling, C., Michault, A., & Paganin, F. (2007). Outbreak of chikungunya on Reunion Island: early clinical and laboratory features in 157 adult patients. Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America, 44(11), 1401-7.
Borgherini G, et al. Outbreak of Chikungunya On Reunion Island: Early Clinical and Laboratory Features in 157 Adult Patients. Clin Infect Dis. 2007 Jun 1;44(11):1401-7. PubMed PMID: 17479933.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Outbreak of chikungunya on Reunion Island: early clinical and laboratory features in 157 adult patients. AU - Borgherini,Gianandrea, AU - Poubeau,Patrice, AU - Staikowsky,Frederik, AU - Lory,Manuella, AU - Le Moullec,Nathalie, AU - Becquart,Jean Philippe, AU - Wengling,Catherine, AU - Michault,Alain, AU - Paganin,Fabrice, Y1 - 2007/04/18/ PY - 2006/12/16/received PY - 2007/02/15/accepted PY - 2007/5/8/pubmed PY - 2007/6/15/medline PY - 2007/5/8/entrez SP - 1401 EP - 7 JF - Clinical infectious diseases : an official publication of the Infectious Diseases Society of America JO - Clin Infect Dis VL - 44 IS - 11 N2 - BACKGROUND: Chikungunya is a reemerging disease. In 2005-2006, a severe outbreak occurred on Reunion Island in the southwestern part of the Indian Ocean. Other islands in this area were affected during the same period. METHODS: Adult patients with acute chikungunya (defined as onset of fever and/or polyarthralgia in the 5 days preceding consultation) and laboratory-confirmed chikungunya who were referred to Groupe Hospitalier Sud Reunion during the period from March 2005 through April 2006 were included in this retrospective study. Their clinical and laboratory features are reported. RESULTS: Laboratory-confirmed acute chikungunya was documented in 157 patients. The mean age of patients was 57.9 years, and the ratio of male to female patients was 1.24 : 1. Sixty percent of patients had at least 1 comorbidity. Ninety-seven patients (61.8%) were hospitalized, and 60 (38.2%) were treated as outpatients. Five fatalities were reported. One hundred fifty-one patients (96.1%) experienced polyarthralgia, and 129 (89%) experienced fever. Gastrointestinal symptoms were reported by 74 patients (47.1%), and skin rash was reported by 63 (40.1%). Hemorrhagic signs were rare. Lymphopenia and hypocalcemia were the prominent laboratory findings. Severe thrombocytopenia was rarely observed. CONCLUSIONS: Chikungunya virus can be responsible for explosive outbreaks of disease. Polyarthralgia and fever are the 2 main clinical features. In this era of travel and globalization, chikungunya should be considered in the differential diagnosis of febrile polyarthralgia with an abrupt onset. SN - 1537-6591 UR - https://www.unboundmedicine.com/medline/citation/17479933/Outbreak_of_chikungunya_on_Reunion_Island:_early_clinical_and_laboratory_features_in_157_adult_patients_ L2 - https://academic.oup.com/cid/article-lookup/doi/10.1086/517537 DB - PRIME DP - Unbound Medicine ER -