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AgOTf-catalyzed three-component reactions of 2-alkynylbenzaldehydes, amines, and diethylphosphite. An efficient route to 2,3-disubstituted-1,2-dihydroisoquinolin-1-ylphosphonates.
J Comb Chem. 2007 Jul-Aug; 9(4):690-4.JC

Abstract

AgOTf was discovered as a highly efficient catalyst in reactions of 2-alkynylbenzaldehydes, amines, and diethylphosphite, which provided a facile and efficient pathway for the synthesis of 2,3-disubstituted-1,2-dihydroisoquinolin-1-ylphosphonates.

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Authors+Show Affiliations

Sun W
Department of Chemistry, Fudan University, 220 Handan Road, Shanghai, 200433, P. R. China.
Ding Q
No affiliation info available
Sun X
No affiliation info available
Fan R
No affiliation info available
Wu J
No affiliation info available

MeSH

AlkylationAminesBenzaldehydesCatalysisHydrogenIsoquinolinesMesylatesMolecular StructureOrganophosphonatesPhosphites

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17480059

Citation

Sun, Wei, et al. "AgOTf-catalyzed Three-component Reactions of 2-alkynylbenzaldehydes, Amines, and Diethylphosphite. an Efficient Route to 2,3-disubstituted-1,2-dihydroisoquinolin-1-ylphosphonates." Journal of Combinatorial Chemistry, vol. 9, no. 4, 2007, pp. 690-4.
Sun W, Ding Q, Sun X, et al. AgOTf-catalyzed three-component reactions of 2-alkynylbenzaldehydes, amines, and diethylphosphite. An efficient route to 2,3-disubstituted-1,2-dihydroisoquinolin-1-ylphosphonates. J Comb Chem. 2007;9(4):690-4.
Sun, W., Ding, Q., Sun, X., Fan, R., & Wu, J. (2007). AgOTf-catalyzed three-component reactions of 2-alkynylbenzaldehydes, amines, and diethylphosphite. An efficient route to 2,3-disubstituted-1,2-dihydroisoquinolin-1-ylphosphonates. Journal of Combinatorial Chemistry, 9(4), 690-4.
Sun W, et al. AgOTf-catalyzed Three-component Reactions of 2-alkynylbenzaldehydes, Amines, and Diethylphosphite. an Efficient Route to 2,3-disubstituted-1,2-dihydroisoquinolin-1-ylphosphonates. J Comb Chem. 2007 Jul-Aug;9(4):690-4. PubMed PMID: 17480059.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - AgOTf-catalyzed three-component reactions of 2-alkynylbenzaldehydes, amines, and diethylphosphite. An efficient route to 2,3-disubstituted-1,2-dihydroisoquinolin-1-ylphosphonates. AU - Sun,Wei, AU - Ding,Qiuping, AU - Sun,Xiaoyu, AU - Fan,Renhua, AU - Wu,Jie, Y1 - 2007/05/05/ PY - 2007/5/8/pubmed PY - 2007/9/1/medline PY - 2007/5/8/entrez SP - 690 EP - 4 JF - Journal of combinatorial chemistry JO - J Comb Chem VL - 9 IS - 4 N2 - AgOTf was discovered as a highly efficient catalyst in reactions of 2-alkynylbenzaldehydes, amines, and diethylphosphite, which provided a facile and efficient pathway for the synthesis of 2,3-disubstituted-1,2-dihydroisoquinolin-1-ylphosphonates. SN - 1520-4766 UR - https://www.unboundmedicine.com/medline/citation/17480059/AgOTf_catalyzed_three_component_reactions_of_2_alkynylbenzaldehydes_amines_and_diethylphosphite__An_efficient_route_to_23_disubstituted_12_dihydroisoquinolin_1_ylphosphonates_ L2 - https://doi.org/10.1021/cc070030z DB - PRIME DP - Unbound Medicine ER -